Cognitive Discovery Pipeline Applied to Informal Knowledge

The Discovery Channel: microfluidics and microengineered systems in drug screening

Integrative Biology ◽

10.1039/c5ib90004b ◽

2015 ◽

Vol 7 (3) ◽

pp. 285-288 ◽

Cited By ~ 5

Author(s):

Christopher Moraes

Keyword(s):

Drug Discovery ◽

Engineering Design ◽

High Throughput ◽

Drug Screening ◽

High Throughput Screening ◽

Recent Literature ◽

Analytical Strategies ◽

Discovery Pipeline

We highlight exciting findings and promising approaches in the recent literature in which researchers integrate advanced micro-engineering, design, and analytical strategies to improve the relevance and utility of high-throughput screening in the drug discovery pipeline.

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Machine learning and molecular dynamics simulations assisted evolutionary design and discovery pipeline to screen the efficient small molecule acceptors for PTB7-Th based organic solar cells with over 15% efficiency

Journal of Materials Chemistry A ◽

10.1039/d1ta09762h ◽

2022 ◽

Author(s):

Jin-Liang Wang ◽

Asif Mahmood ◽

Ahmad Irfan

Keyword(s):

Machine Learning ◽

Molecular Dynamics ◽

Solar Cells ◽

Molecular Dynamics Simulations ◽

Small Molecule ◽

Organic Solar Cells ◽

Evolutionary Design ◽

New Materials ◽

Dynamics Simulations ◽

Discovery Pipeline

Organic solar cells are the most promising candidates for future commercialization. This goal can be quickly achieved by designing new materials and predicting their performance without experimentation to reduce the...

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Informal knowledge processes: the underpinning for sustainability outcomes in EIA?

Journal of Cleaner Production ◽

10.1016/j.jclepro.2009.09.002 ◽

2010 ◽

Vol 18 (1) ◽

pp. 6-13 ◽

Cited By ~ 41

Author(s):

Alan J. Bond ◽

Cláudia V. Viegas ◽

Christianne Coelho de Souza Reinisch Coelho ◽

Paulo Maurício Selig

Keyword(s):

Informal Knowledge ◽

Knowledge Processes

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Legitimizing indigenous knowledge in Zimbabwe: A theoretical analysis of postcolonial school knowledge and its colonial legacy

Journal of Contemporary Issues in Education ◽

10.20355/c5rp4j ◽

2006 ◽

Vol 1 (1) ◽

Cited By ~ 30

Author(s):

Edward Shizha

Keyword(s):

Indigenous Knowledge ◽

Educational Institutions ◽

School Knowledge ◽

Colonial Legacy ◽

Construction Of Knowledge ◽

Informal Knowledge ◽

Self Confidence ◽

The Social ◽

Social Construction Of Knowledge ◽

Postcolonial States

This article is a theoretical discussion on the social construction of knowledge in colonial and postcolonial Zimbabwe. It examines effects of hegemonic knowledge constructions and how they may be de-legitimated through incorporating indigenous knowledge in postcolonial school curricular. The article questions the importance attached to Euro-centric school knowledge and the devaluation of indigenous knowledge in postcolonial states. It further argues that indigenous knowledge as informal knowledge plays a major role in society and should be formalized in educational institutions to constitute a transformative and inclusive educational system. The article proposes hybridization of knowledge to give voice to the formerly marginalized in school curricular in Zimbabwe. It also proposes that knowledge as a historical, cultural, social, spiritual and ideological creation should be a product of collaborated efforts from all possible stakeholders to foster social development and self-confidence in individuals.

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Triggering fourth graders’ informal knowledge of isometric transformation geometry through the exploration of Malay cloth motif

JOURNAL OF EDUCATIONAL SCIENCES ◽

10.31258/jes.2.1.p.26-36 ◽

2018 ◽

Vol 2 (1) ◽

pp. 26

Author(s):

Febrian Febrian ◽

Sukma Adi Perdana

Keyword(s):

Elementary School ◽

Design Research ◽

Fourth Graders ◽

Informal Knowledge ◽

Spatial Sense ◽

Isometric Transformation ◽

Hands On ◽

The Subject ◽

Transformation Geometry ◽

Triggering Process

Existing study revealed that the children have dynamics spatial sense on objects. One of important mathematics topics that can be related to the sense-triggering process is the isometric transformation geometry including reflection, translation, and rotation. This topic is introduced to the fourth and the fifth graders of elementary school. However, learning process in school tends to lack concern on this students’ readily-triggered ability. There is also insufficient number of hands-on activities experienced by the students. It is poor since the hands-on activities can facilitate students’ informal knowledge of isometric transformation geometry. Therefore, this two cycled design research aims to counter such situation. It was conducted at State Elementary School 001 of Toapaya, Kabupaten Bintan, Kepulauan Riau by using RME approach. The subject of the study was the fourth graders. Malay cloth motif was used as the context of the study through the exploration activities. The results indicated that the activities could trigger students’ informal knowledge of: reflection, translation, rotation, constant factors, and transformation composition.

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Synergistic effects of natural products and commercial antibiotics

10.1101/2020.09.01.20186353 ◽

2020 ◽

Author(s):

Lucia Nitsch-Velasquez

Keyword(s):

Natural Products ◽

Synergistic Effects ◽

Gram Negative Bacteria ◽

Polar Solvents ◽

Microbial Strains ◽

Polar Extracts ◽

Review Reports ◽

New Treatments ◽

Discovery Pipeline

Context: The antimicrobial resistant era requires advances in the approaches and technologies to find new treatments. The enhancement of the antimicrobial activity of commercially available drugs (CADs) by natural products (NPs) has successful mixtures (e.g., clavulanic acid and amoxicillin). Objective: To systematically review reports of synergistic effects of CADs and NPs against opportunistic microbial strains from 2010 to April 2016. Methods: The databases and search engines PubMed, Medline, Scifinder, Scopus, ScienceDirect, Scholar Google were systematically searched. Among the keywords utilized were: synergistic effects natural products and antibioitcs, botanicals and antibiotics bioassays, plant extracts interaction with antibioitics and antibiotic adjuvant bioassays. Only synergistic results were tabulated and analyzed according to CADs, NPs and strains. Results: A set of 76 studies that reported in vitro synergistic effects of CADs and NPs against gram−positive or gram−negative bacteria or fungi opportunistic strains was found. From the 60 reports on antibacterial adjuvants, the most frequent designs involved beta−lactamics or aminoglycosides against Methicillin Resistant Staphylococcus aureus. The assayed NPs encompassed extracts or fractions from 22 different species distributed worldwide (45% extracted with non−polar solvents) and 33 purified compounds (flavonoids, other polyphenols and alkaloids). Conclusions: NPs as potential drug hits for antimicrobial adjuvants had been found and should continue in the drug discovery pipeline. The field certainly would benefit of advances in purification technologies, especially for polar extracts and bioassay platforms.

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