The Convergence of Slide-Type Reductions

Abstract Context.—Previous studies have shown that in gynecologic cytology, cases of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) perform differently on interpretive review. The performance of cases with mixed LSIL and HSIL features is unknown. Objective.—To compare the performance of gynecologic cytology cases of “pure” LSIL and HSIL with cases showing mixed LSIL and HSIL features. Design.—We compiled performance data from the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytopathology from the years 2003 and 2004, and compared the performance of slides showing relatively pure LSIL and HSIL (≤10% misclassification as HSIL and LSIL, respectively) with slides showing mixed LSIL or HSIL features (cases misclassified as LSIL or HSIL >10% of the time). Results.—Interpretations from a total of 4508 cases (2452 HSIL and 2056 LSIL) were analyzed. Overall, the sensitivity of participants on slides with a reference diagnosis of HSIL was 97.3%, and of LSIL was 95.9%. Performance trends for pure versus mixed cases varied by slide type and reference diagnosis. For conventional slides, participant sensitivity on pure HSIL cases was greatest (98.0%) and on pure LSIL cases was least (95.2%), while participant performance on cases with mixed features was intermediate (97.0% for mixed HSIL and 96.7% for mixed LSIL). In contrast, participant performance on ThinPrep slides showed the greatest sensitivity for mixed LSIL slides (97.9%), while performance on mixed HSIL slides showed the lowest sensitivity (95.7%); slides with pure features had intermediate sensitivity levels (96.3% for both HSIL and LSIL). Further evaluation demonstrated that conventional pure HSIL slides performed significantly better than mixed HSIL slides (P = .006), whereas mixed LSIL slides performed better than pure LSIL slides (P = .01). For ThinPrep slides, pure HSIL cases performed similarly to mixed HSIL cases (P = .43), while mixed LSIL cases performed better than pure LSIL cases (P = .04). Conclusion.—Slides with mixed LSIL and HSIL features have measurably distinct performance characteristics in comparison to slides with pure LSIL or HSIL features. Participant performance on conventional mixed cases is distinctly different from performance on ThinPrep mixed cases.

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J113023 Slide Type Flexible Fluid Powered Actuator : Λ-drive and Its Application

The Proceedings of Mechanical Engineering Congress Japan ◽

10.1299/jsmemecj.2012._j113023-1 ◽

2012 ◽

Vol 2012 (0) ◽

pp. _J113023-1-_J113023-5

Author(s):

Hideyuki TSUKAGOSHI ◽

Yotaro MORI ◽

Ato KITAGAWA

Keyword(s):

Slide Type

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Landslides, river incision and environmental change: the Ruzizi gorge in the Kivu Rift

10.5194/egusphere-egu21-11067 ◽

2021 ◽

Author(s):

Toussaint Mugaruka Bibentyo ◽

Antoine Dille ◽

Arthur Depicker ◽

Benoît Smets ◽

Matthias Vanmaercke ◽

...

Keyword(s):

Land Use ◽

Land Reclamation ◽

Added Value ◽

Aerial Photographs ◽

Vegetation Growth ◽

River Incision ◽

Multi Temporal ◽

Recent Activity ◽

Slide Type ◽

The City

<p>The understanding of the interplay between natural and human induced factors in the occurrence of landslides remains poorly constrained in many regions, especially in tropical Africa where data-scarcity is high. In these regions where population growth is significant and causes changes in land use/cover, the need for a sustainable management of the land is on the rise. Here, we aim to unravel the occurrence of landslides in the 40 km-long Ruzizi gorge, a rapidly incising bedrock river in the Kivu Rift in Africa that has seen its landscape disturbed over the last decades by the development of the city of Bukavu (DR Congo). Careful field observations, historical aerial photographs, satellite imagery and archive analysis are combined to produce a multi-temporal inventory of 264 landslides. We show that the lithological context of the gorge and its extremely high incision rate (> 20 mm year<sup>-1</sup>) during the Holocene explains the presence of a concentration of large landslides (up to 2 km&#178;) of undetermined age (well before the first observations of 1959) whose occurrence is purely natural. They are mostly of the slide type and do not show morphologic patterns of recent activity. The landslides that occurred during the last 60 years are flow-like shallower slope failures of smaller size (up to 0.12 km&#178;) and tend to disappear rather quickly (sometimes within a few years) from the landscape as a result of rapid vegetation growth, land reclamation and (human-induced) soil erosion. They are primarily related to threshold slopes and precipitation plays a frequent role in their onset. However, land use/cover changes also affect their occurrence. This study provides useful information for a more accurate evaluation of the landslide hazard in the area, particularly with respect to the growth of the city of Bukavu that has developed without the consideration of naturally instable slopes. It also stresses the need and added value of building accurate landslide inventories in data-scarce regions.</p>

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Comparison of frictional resistance between passive self-ligating brackets and slide-type low-friction ligature brackets during the alignment and leveling stage

Journal of Clinical and Experimental Dentistry ◽

10.4317/jced.55913 ◽

2019 ◽

pp. 0-0

Author(s):

SL Gomez-Gomez ◽

JA Villarraga-Ossa ◽

JG Diosa-Pena ◽

JF Ortiz-Restrepo ◽

RA Castrillon-Marin ◽

...

Keyword(s):

Frictional Resistance ◽

Low Friction ◽

Slide Type

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In vitro Retention Loss of Attachment-retained Removable Partial Denture

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1449 ◽

2013 ◽

Vol 14 (6) ◽

pp. 1049-1053

Author(s):

Gülsen Can ◽

Baransel Özmumcu ◽

Pinar Altinci

Keyword(s):

Test Machine ◽

Clinical Use ◽

Removable Partial Denture ◽

Partial Denture ◽

Retention Force ◽

Retention Loss ◽

Custom Made ◽

Slide Type ◽

Over Time

ABSTRACT Aim To investigate the importance of attachment types on the retention loss of extracoronal attachment-retained removable partial dentures depending on the usage period. Materials and methods In order to observe the retention loss of 5 different attachments (OT Strategy, OT Strategy-metal protected, Vario-stud-snap and Vario-soft 3 and ERA-RV) over time, attachment-retained partial dentures representing Kennedy II mod. I case were placed in a custom-made, retention test machine. For each minute, eight separating and joining movements were performed and retention values (Newton) of the attachments were recorded by computer. The retention tests implemented in 540,1080 and 2160 cycles. The data were evaluated statistically according to the two-way ANOVA and Tukey parametrical tests. Results The slide type attachment providing the best retention force was observed to be the most worn out by this process (p < 0.01) while the ball type attachments, which typically have the lesser retention force, showed less retention loss (p < 0.01). Conclusion It can be concluded that the retention attributes of the attachment-retained dentures were affected by the specific type of precision attachment as well as the usage period. Clinical significance Precision attachments with ball-type plastic matrices may be recommended for the clinical use due to their retention stability over time. How to cite this article Can G, Özmumcu B, Altinci P. In vitro Retention Loss of Attachment-retained Removable Partial Denture. J Contemp Dent Pract 2013;14(6):1049-1053.

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Development of a diagnostic PD-L1 immunohistochemical assay for nivolumab therapy in urothelial carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e14585 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e14585-e14585 ◽

Cited By ~ 1

Author(s):

Rose Ann De Los Santos ◽

Josette William ◽

Debra Ann Hanks ◽

Adam Northrup ◽

Dipeshkumar Jaiswal ◽

...

Keyword(s):

Urothelial Carcinoma ◽

Tumor Cells ◽

Staining Intensity ◽

Observer Agreement ◽

Formalin Fixed Paraffin ◽

Wide Range ◽

Formalin Fixed Paraffin Embedded ◽

Staining Protocol ◽

Visualization Technology ◽

Slide Type

e14585 Background: PD-L1 IHC 28-8 pharmDx is a qualitative assay developed by Agilent Technologies for the Autostainer Link 48 platform and is based on EnVision FLEX visualization technology and monoclonal rabbit anti-PD-L1, clone 28-8 antibody. The assay has been co-developed with the immunotherapeutic agent nivolumab; initially as an aid in assessing PD-L1 expression in non-squamous non-small cell lung cancer (NSCLC) and melanoma patients. Here we describe the efforts to validate this assay for urothelial carcinoma (UC). Methods: IHC staining was performed on Autostainer Link 48 platform using an automated staining protocol stated per the assay’s instruction for use (IFU). Specimens were coverslipped and interpreted for % PD-L1 positive tumor cells. The assay was analytically validated on commercially acquired formalin-fixed, paraffin-embedded (FFPE) human UC invasive tumor specimens at ≥1% and ≥5% PD-L1 positive tumor cells expression levels. Results: A wide range of % PD-L1 positive tumor cells at all staining intensity levels have been detected. Assay in-house precision was validated for inter-operator, inter-instrument, inter-day, inter-run and intra-run as well as inter-observer and intra-observer agreement. Robustness studies evaluated the assay under multiple conditions for target retrieval pH, temperature and incubation time, slide type as well as tissue section thickness. Assay reproducibility was evaluated at three external sites by testing samples for intra-site/inter-day and inter-site agreement measures. Specimens were also evaluated by an observer at each site, with three reads for each observer to assess intra-observer and inter-observer agreement. All validation studies demonstrated agreement estimates above 85% with values for lower bound 95% confidence intervals calculated above 84%. Conclusions: Results of all conducted studies show high robustness and reproducibility of the assay on UC.

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