Biomarkers in Endocrine Organ Carcinomas

2022 ◽  
pp. 129-164
Author(s):  
Yasemin Sahin ◽  
Merih Guray Durak ◽  
Ozgur Mete
Keyword(s):  
Endocrine Organ

METABOLIC AND ENDOCRINE ASPECTS OF THE WHIRLER MUTATION IN MALE MICE

1970 ◽  
Vol 64 (2) ◽  
pp. 347-358
Author(s):  
A. Stanley Weltman ◽  
Arthur M. Sackler
Keyword(s):  
Locomotor Activity ◽  
Endocrine Function ◽  
Metabolic Rates ◽  
Heterozygous Female ◽  
Endocrine Organ ◽  
General Body ◽  
Adrenocortical Activity ◽  
Body Weights ◽  
Seminal Vesicle Weight ◽  
Eosinophil Counts

ABSTRACT Body weight, metabolic rate, locomotor activity and alterations in endocrine organ activity were noted in recessive homozygous male whirler mice and the phenotypically »normal« heterozygotes. Representative populations of the two types were studied at different age levels. In general, body weights of the whirler mice were consistently and significantly lower. Open-field locomotion studies similarly indicated heightened locomotor activity. Total leukocyte and eosinophil counts were either markedly or significantly lower in the homozygous vs. heterozygous whirler groups. Evaluation of relative organ weights showed significantly increased adrenal weights in whirler mice sacrificed at 14 weeks and 11 months of age. These changes were accompanied by involution of the thymus. Thus, the varied data indicate persistent increased metabolism and adrenocortical activity during the life-span of the whirler mice. Seminal vesicle weight decreases in the whirler males at 11 months suggest lower gonadal function. The findings are in accord with previous studies of alterations in metabolic rates and endocrine function of homozygous whirler vs. heterozygous female mice.

The Brain: An Endocrine Organ and Hormone Target

Science ◽  
1974 ◽  
Vol 186 (4169) ◽  
pp. 1137-1138 ◽  
Author(s):  
W. E. Stumpf ◽  
L. D. Grant
Keyword(s):  
Endocrine Organ ◽  
The Brain

scholarly journals Adipose Tissue as an Endocrine Organ

Obesity ◽  
2006 ◽  
Vol 14 ◽  
pp. 242S-249S ◽  
Author(s):  
Rexford S. Ahima
Keyword(s):  
Adipose Tissue ◽  
Endocrine Organ

The endothelial cell as a metabolic and endocrine organ

1987 ◽  
Vol 8 (12) ◽  
pp. 491-496 ◽  
Author(s):  
J.R. Vane ◽  
R.J. Gryglewski ◽  
R.M. Botting
Keyword(s):  
Endothelial Cell ◽  
Endocrine Organ

scholarly journals Myokines as Possible Therapeutic Targets in Cancer Cachexia

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Emilia Manole ◽  
Laura C. Ceafalan ◽  
Bogdan O. Popescu ◽  
Carmen Dumitru ◽  
Alexandra E. Bastian
Keyword(s):  
Cancer Cachexia ◽  
Therapeutic Targets ◽  
Fibroblast Growth Factor 21 ◽  
Complex Phenomenon ◽  
Fibroblast Growth ◽  
Endocrine Organ ◽  
Response To Chemotherapy ◽  
Interleukin 15 ◽  
New Research

Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient’s quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15.

scholarly journals Equine metabolic syndrome in Colombian creole horse: case report

2017 ◽  
Vol 69 (5) ◽  
pp. 1067-1072
Author(s):  
C.A. Castillo ◽  
C. Jaramillo ◽  
M.J. Loaiza ◽  
R. Blanco
Keyword(s):  
Metabolic Syndrome ◽  
Case Report ◽  
Clinical Signs ◽  
South American ◽  
Adequate Treatment ◽  
Endocrine Organ ◽  
Equine Metabolic Syndrome ◽  
First Case ◽  
Combined Test ◽  
Lack Of Exercise

ABSTRACT The equine metabolic syndrome is a condition that can be recognized because of obesity, insulin resistance and laminitis. Genetic factors could play a role in the occurrence of this syndrome. Certain breeds such as ponies (including the South American creole horses) have a lower sensibility to insulin and a higher prevalence of hyperinsulinemia. The environment and management conditions, such as overfeeding and lack of exercise are factors that bring a propensity for obesity. The adipose tissue works as an endocrine organ producing hormones (adipokines or adipocytokines) that affect the horse´s metabolism. The objective of this report is to describe the first case report of a Colombian creole mare with a metabolic syndrome, diagnosed by means of the combined test of glucose-insulin and clinical signs. Early diagnosis of this entity and an adequate treatment are useful for improving the life and the zootechnical conditions of the patient.

scholarly journals Pembrolizumab-Induced Thyroiditis Shows PD-L1Expressing Histiocytes and Infiltrating T Cells in Thyroid Tissue - A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Jörg Jabkowski ◽  
Almute Loidl ◽  
Barbara Auinger ◽  
Helmut Kehrer ◽  
Norbert Sepp ◽  
...  
Keyword(s):  
T Helper Cells ◽  
Checkpoint Inhibitors ◽  
Thyroid Tissue ◽  
T Helper ◽  
Endocrine Organ ◽  
Self Tolerance ◽  
Pathological Mechanism ◽  
De Quervain ◽  
Immunological Process ◽  
Initial Target

ContextImmune-related adverse events frequently take place after initiation of immune checkpoint inhibitors (ICI) therapy. The thyroid gland is the endocrine organ most commonly affected by ICI therapy, the pathological mechanism is still poorly understood.Case DescriptionA 60-year old Upper Austrian male melanoma patient under pembrolizumab therapy received thyroidectomy because of a suspicious FDG avid thyroid nodule. Histopathology showed a pattern comparable with thyroiditis de Quervain. The inflammatory process consisted predominantly of T lymphocytes with a dominance of CD4+ T helper cells. In addition CD68+ histiocytes co-expressing PD-L1 were observed.ConclusionClusters of perifollicular histiocytes expressing PD-L1 were observed in this case of pembrolizumab induced thyroiditis - probably induced by the former ICI therapy. This finding might indicate the initial target for the breakdown of self tolerance. In context with other data the immunological process seems to be driven by CD3+ lymphocytes infiltrating the thyroid.

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