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2022 ◽  
Vol 3 (2) ◽  
pp. 86-109
Author(s):  
Jessica Artanti ◽  
Prima M. Agustini ◽  
Arief Saptono ◽  
Gilang Kartika Hanum ◽  
Regina D.O.

This study aims to analyze the marketing strategy of Mitra Bukalapak in increasing customer satisfaction. In this study, the researcher uses a qualitative approach, which aims to find out what strategies are used by Bukalapak's internal partners to increase Customer Satisfaction. The data used for this research are primary data and secondary data. The results of the research analysis using in-depth interviews with the internal parties of Bukalapak Partners and Bukalapak Partners as triangulators where they transact using the Bukalapak Partner application as a place to transact. The segment of Mitra Bukalapak is for all levels, where the initial target is the klontong shop and the product positioning offered is virtual and wholesale products. From the 7P marketing mix implemented by Bukalapak Partners internally, there are several strategies that still need to be addressed, one of which is the price strategy because the price is still a sensitive issue, especially for buyers who are price-sensitive. However, there are also strategies that have been created and implemented that can accepted by Bukalapak Partners.


Author(s):  
Sunny Le Galloudec

Although history ultimately favored the portuary development of SàiGòn and HảiPhòng, it was Tourane (ĐNẵng) that was the initial target of French colonial ambitions in the Indochinese peninsula. For over a century (17401858), its bay and territory had been the scene and the epicenter of Franco-British overseas imperial rivalries, a fact which actively fostered an entire set of colonial images about the site, which was quite often referred to as potential base to serve the interests of commerce and the Navy. Despite these ambitions nurtured over a long period, it was only after the conquest of Tonkin, thirty years after the Cochinchina expedition, that its territory was finally established as a concession: on 3 October 1888, the French were finally seizing juridical control of Tourane. As a conceded territory, Tourane was essential to French colonial and imperial designs. The focal point of political and economic ambitions, it was both a gateway and a means to prepare and support the French colonial project in Indochina. A hybrid and previously unknown template, the conceded territory model designed for, and from, Tourane indeed allowed the French to implement new strategies to tighten colonial rule in Indochina. Offering an unprecedented analysis on the creation of the French concession of Tourane at the end of the 19th century, this research examines the political context during which it was conceived, the work and conclusions given by the commission in charge of studying its borders and jurisdiction, and the steps taken by the colonial administration in order to seize definitive control of a strategic territory inside what was then left of the Đại Nam Kingdom. All in all, comparing Tourane with others treaty ports, it shows how and why its territory stood out as a micro-colony in a protectorate territory (Annam-Tonkin).


2021 ◽  
Vol 3 (2) ◽  
pp. 72-81
Author(s):  
I Wayan Raka Ardana ◽  
Lalu Febrian Wiranata ◽  
Ida Bagus Irawan Purnama

Regulating the output voltage based on the desired set point is useful for many applications. However, getting the optimal value using fast computation with minimal error is still challenging. This paper aims to design, simulate, and implement a second-order Buck-Boost DC-DC converter circuit so that the voltage result according to the desired set point can be achieved. Initially, testing is conducted using Matlab Simulink. Then, Proteus is used to test the computation of the program on embedded systems in which the result is implemented in C. In low voltage power electronics applications, this approach has never been used to determine the output form. To determine the value of Kp, Ki, dan Kd, PID, Ziger Nichos (Guo, 2002). method is used. Meanwhile, tuning is done through Matlab. For simulation on Proteus, the output is tested by setting the setpoint values of 3.0, 2.5, and 1.7 volts. This aims to see the pattern of changes in the simulation. The simulation results with Proteus show that they have similar peak values but with different overshoot values. This is because the simulation must pass the reference voltage before it drops to the desired setpoint value. Proteus simulation can also help to prove embedded system programs are running correctly. On the other hand, the value of 1.7 volts is used as a setpoint in device implementation. This is due to the determination that the setpoint voltage in the implementation does not exceed the value of the source/power supply. The results show that for the rise time value of 378,770 ms, Overshoot and settling time are 11.798% and 0, respectively. This means the result produces an optimal value which is a return to the initial target. The optimal factor is assessed from the ability to minimize existing errors as well as having the shortest possible computational process.


Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 8100
Author(s):  
Bin Yu ◽  
Ming Tang ◽  
Guibo Zhu ◽  
Jinqiao Wang ◽  
Hanqing Lu

Bounding box estimation by overlap maximization has improved the state of the art of visual tracking significantly, yet the improvement in robustness and accuracy is restricted by the limited reference information, i.e., the initial target. In this paper, we present DCOM, a novel bounding box estimation method for visual tracking, based on distribution calibration and overlap maximization. We assume every dimension in the modulation vector follows a Gaussian distribution, so that the mean and the variance can borrow from those of similar targets in large-scale training datasets. As such, sufficient and reliable reference information can be obtained from the calibrated distribution, leading to a more robust and accurate target estimation. Additionally, an updating strategy for the modulation vector is proposed to adapt the variation of the target object. Our method can be built on top of off-the-shelf networks without finetuning and extra parameters. It yields state-of-the-art performance on three popular benchmarks, including GOT-10k, LaSOT, and NfS while running at around 40 FPS, confirming its effectiveness and efficiency.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Duo-Meng Yang ◽  
Ting-Ting Geng ◽  
Andrew G. Harrison ◽  
Peng-Hua Wang

AbstractRetinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in MDA5−/− and MAVS−/−, but not in RIG-I−/−, when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2), the cellular entry receptor for SARS-CoV-2, was ~ 2.5-fold higher in RIG-I−/− than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor, IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells.


Author(s):  
Stephen H. Adamo ◽  
Brian J. Gereke ◽  
Sarah Shomstein ◽  
Joseph Schmidt

AbstractFor over 50 years, the satisfaction of search effect has been studied within the field of radiology. Defined as a decrease in detection rates for a subsequent target when an initial target is found within the image, these multiple target errors are known to underlie errors of omission (e.g., a radiologist is more likely to miss an abnormality if another abnormality is identified). More recently, they have also been found to underlie lab-based search errors in cognitive science experiments (e.g., an observer is more likely to miss a target ‘T’ if a different target ‘T’ was detected). This phenomenon was renamed the subsequent search miss (SSM) effect in cognitive science. Here we review the SSM literature in both radiology and cognitive science and discuss: (1) the current SSM theories (i.e., satisfaction, perceptual set, and resource depletion theories), (2) the eye movement errors that underlie the SSM effect, (3) the existing efforts tested to alleviate SSM errors, and (4) the evolution of methodologies and analyses used when calculating the SSM effect. Finally, we present the attentional template theory, a novel mechanistic explanation for SSM errors, which ties together our current understanding of SSM errors and the attentional template literature.


2021 ◽  
Vol 8 (9) ◽  
pp. 1508
Author(s):  
Chandan Raybarman

Background: The aim of the retrospective study was to evaluate the effectiveness of the index antiepileptic drugs in children with idiopathic generalized epilepsy who underwent at least 2 years remission.Methods: A total of 52 children with idiopathic generalized epilepsy who underwent at least 2 years remission were identified retrospectively from the records of the paediatric and neurology care clinic from April 2017 to December 2020.Results: The seizure patterns of 52 cases were tonic-clonic seizures alone (73%), a combination of tonic-clonic seizures and absences (13.5%), and combined tonic-clonic seizures and myoclonus (13.5%).  The total number of seizures at enrolment in all (age at seizure onset 7.44±5.12 years, male-female ratio (31:21) was 651 (mean 12.52±26.60). The total number of follow-up visits in all was 6.62±14.44 consisting of 1177.5±772.86 days of follow-up periods. All patients continued index antiepileptic drugs with initial target doses varies from low to moderate ranges. Add-on therapy was initiated in 43% of cases around the titration phase of index antiepileptic drugs (i.e. very early add-on). Treatment trends reveal increased use of 1st generation antiepileptic drugs than 2nd and 3rd generation. 2 years seizure remission rates were 55.77% by index antiepileptic drugs only therapy and 44.23% by very early add-on therapy.  The seizure remission period was mean±SD 858.71±209.08 days.Conclusions: Index antiepileptic drugs with low to moderate initial target doses lead to achieving 2 years or more seizure remission. Very early add-on therapy is the novelty and leads to achieving the goal.


Author(s):  
Lisa Reyes Mason ◽  
Christine C. Ekenga

Abstract Objective: Weather extremes are increasing with climate change and associated with higher morbidity and mortality. Promotion of social connections is an emerging area of research and practice for risk reduction during weather extremes. This study examines the practice of checking on neighbors during extreme summer heat and extreme winter weather. Objectives are to (1) describe the extent of neighbor checking during these extremes, and (2) examine factors associated with neighbor checking. Methods: We analyze survey data (n = 442) from a primarily low- and moderate- income study sample in a Southeastern U.S. city, using descriptive statistics and logistic regression. Results: About 17.6% of participants checked on neighbors during extreme summer heat, and 25.2% did so during extreme winter weather. Being middle or older aged and having more adverse physical health impacts were positively associated with neighbor checking, for both extremes. For winter only, having less education was positively associated with neighbor checking. Conclusions: Community-based partnerships for reducing risk during weather extremes may consider people who are older or have experienced their own adverse health impacts as initial target groups for promoting neighbor checking. Future research should also examine the motivations for, details about, and impacts of neighbor checking in greater depth.


2021 ◽  
Vol 26 ◽  
pp. 100958
Author(s):  
Tsuyoshi Tsukada ◽  
Hiroki Shimada ◽  
Hiromi Sakata-Haga ◽  
Hiroki Shoji ◽  
Hideaki Iizuka ◽  
...  

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Elgin Hoffmann ◽  
Kerstin Clasen ◽  
Bettina Frey ◽  
Jakob Ehlers ◽  
Felix Behling ◽  
...  

Abstract Background Atypical meningiomas exhibit a high tendency for tumor recurrence even after multimodal therapy. Information regarding recurrence patterns after additive radiotherapy is scarce but could improve radiotherapy planning and therapy decision. We conducted an analysis of recurrence patterns with regard to target volumes and dose coverage assessing target volume definition and postulated areas of tumor re-growth origin. Prognostic factors contributing to relapse were evaluated. Methods The clinical outcome of patients who had completed additive, somatostatin receptor (SSTR)-PET/CT-based fractionated intensity-modulated radiotherapy for atypical meningioma between 2007 and 2017 was analyzed. In case of tumor recurrence/progression, treatment planning was evaluated for coverage of the initial target volumes and the recurrent tumor tissue. We proposed a model evaluating the dose distribution in postulated areas of tumor re-growth origin. The median of proliferation marker MIB-1 was assessed as a prognostic factor for local progression and new distant tumor lesions. Results Data from 31 patients who had received adjuvant (n = 11) or salvage radiotherapy (n = 20) were evaluated. Prescribed dose ranged from 54.0 to 60.0 Gy. Local control at five years was 67.9%. Analysis of treatment plans of the eight patients experiencing local failure proved sufficient extent of target volumes and coverage of the prescribed dose of at least 50.0 Gy as determined by mean dose, D98, D2, and equivalent uniform dose (EUD) of all initial target volumes, postulated growth-areas, and areas of recurrent tumor tissue. In all cases, local failure occurred in high-dose volumes. Tumors with a MIB-1 expression above the median (8%) showed a higher tendency for re-growth. Conclusions The model showed adequate target volume and relative dose distribution but absolute dose appears lower in recurrent tumors without reaching statistical significance. This might provide a rationale for dose escalation studies. Biological factors such as MIB-1 might aid patients’ stratification for dose escalation.


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