Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige

1999 ◽  
pp. 19-36 ◽  
Author(s):  
Giuseppe Lungarella ◽  
Eleonora Cavarra ◽  
Piero A. Martorana
Keyword(s):  
Tight Skin

scholarly journals Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice

2005 ◽  
Vol 145 (4) ◽  
pp. 424-431 ◽  
Author(s):  
Naotaka Shiota ◽  
Eiichi Kakizoe ◽  
Keiko Shimoura ◽  
Tetsuya Tanaka ◽  
Hideki Okunishi
Keyword(s):  
Mast Cell ◽  
Tight Skin ◽  
Mast Cell Chymase ◽  
Chymase Inhibitor

Lung collagen synthesis and deposition in tight-skin mice with genetic emphysema

1992 ◽  
Vol 56 (2) ◽  
pp. 163-172 ◽  
Author(s):  
C. Gardi ◽  
P.A. Martorana ◽  
P. Calzoni ◽  
P. van Even ◽  
M.M. de Santi ◽  
...  
Keyword(s):  
Collagen Synthesis ◽  
Tight Skin

scholarly journals A Case Report on Scleroderma: A Diagnostic Dilema

2021 ◽  
pp. 251-255
Author(s):  
Ch. K. V. L. S. N. Anjana Male ◽  
Hari Chandana Varikallu ◽  
Tirumalasetty Sai Swapna ◽  
N. Dileep ◽  
S. Hemanth Durga Prasad ◽  
...  
Keyword(s):  
Past History ◽  
Immunosuppressive Agents ◽  
Localized Scleroderma ◽  
Visceral Organ ◽  
Tight Skin ◽  
Heterogenous Group ◽  
Life Threatening ◽  
History Of ◽  
Organ Fibrosis

Scleroderma is a rare heterogenous group of autoimmune fibrosing disorder that mainly exists in two forms; localized scleroderma (LS) and systemic sclerosis (SSc). It involves thickening of the skin at fingers region extending from proximal to metacarpophalangeal joints. The diagnostic criteria of scleroderma include past history of patient, symptoms of patient, serology, and skin biopsy. The morbidity and mortality are much worse for SSc with the patients are at risk for life threatening lung, heart and other visceral organ fibrosis and vasculopathy. There is no drug that can cure or stop scleroderma over fibrosis, but certain drugs regulate the symptoms associated with it and boost the patient's quality of life, particularly steroidal creams that help alleviate swelling, joint pain, loosen tight skin; blood pressure drugs that dilate blood vessels; immunosuppressive agents. If the disease is severe amputation is necessary.

scholarly journals Lack of Skin Fibrosis in Tight Skin (TSK) Mice with Targeted Mutation in the Interleukin-4Rα and Transforming Growth Factor-β Genes

2001 ◽  
Vol 116 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Tracy McGaha ◽  
Shinichiro Saito ◽  
Robert G. Phelps ◽  
Ronald Gordon ◽  
Nancy Noben-Trauth ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Skin Fibrosis ◽  
Tight Skin ◽  
Targeted Mutation

The role of mast cells in the development of skin fibrosis in tight-skin mutant mice

1995 ◽  
Vol 110 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Eric T. Everett ◽  
Jose L. Pablos ◽  
Russell A. Harley ◽  
E. Carwile LeRoy ◽  
James S. Norris
Keyword(s):  
Mast Cells ◽  
Mutant Mice ◽  
Skin Fibrosis ◽  
Tight Skin

A Role for T Helper 2 Cells in Mediating Skin Fibrosis in Tight-Skin Mice

1999 ◽  
Vol 196 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Christopher J. Ong ◽  
Simon Ip ◽  
Soo-Jeet Teh ◽  
Connie Wong ◽  
Frank R. Jirik ◽  
...  
Keyword(s):  
Skin Fibrosis ◽  
T Helper ◽  
T Helper 2 ◽  
Tight Skin
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