Dysmorphic Facies, Tight Skin and Early Death

2012 ◽  
pp. 441-446
Author(s):  
Mohammad Ali El-Darouti
Keyword(s):  
Early Death ◽  
Tight Skin

193: The Relative Risk of Early Death from Comorbid Illnesses among Prostate Cancer Patients Receiving Curative Treatment

2005 ◽  
Vol 173 (4S) ◽  
pp. 53-53 ◽  
Author(s):  
Patti A. Groome ◽  
Susan L. Rohland ◽  
Michael D. Brundage ◽  
Jeremy P.W. Heaton ◽  
William J. Mackillop ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Relative Risk ◽  
Cancer Patients ◽  
Early Death ◽  
Curative Treatment

Clinical features and outcome of acquired haemophilia A

2010 ◽  
Vol 30 (03) ◽  
pp. 156-161 ◽  
Author(s):  
R. Gheisari ◽  
B. Bomke ◽  
T. Hoffmann ◽  
R. E. Scharf
Keyword(s):  
Respiratory Diseases ◽  
Care Center ◽  
Treatment Algorithm ◽  
Early Death ◽  
Underlying Disease ◽  
Pulmonary Sarcoidosis ◽  
Relative Increase ◽  
Laboratory Evaluation ◽  
Haemophilia A ◽  
Acquired Haemophilia

SummaryWe have performed a monocenter study on 29 consecutive patients with acquired haemophilia A who were referred for diagnosis and treatment to the Düsseldorf Haemophilia Comprehensive Care Center between March 2001 and February 2010. Patients, methods: 18 men (age: 44–86 years) and 11 women (age: 20–83 years). For laboratory evaluation, a standardized staged protocol of aPTT, FVIII : C activity and concentration, mixing studies with patient and normal plasma, and quantification of inhibitor titers (Bethesda assay) was used. Diagnostic work-up included elaborate examinations for any underlying disease. Results: In 18 (62%) of the 29 patients with acquired haemophilia A, an underlying disorder was identified, including 9 patients with respiratory diseases (31%), 7 patients with autoimmune disorders (24%), one with malignancy, and one with postpartum state, while in 11 patients (38%) acquired haemophilia A remained idiopathic. Haemotherapy of bleeding, suppression or elimination of the inhibitor, and induction of immunotolerance to endogenous FVIII:C were performed according to a treatment algorithm. Predefined clinical endpoints were control of bleeding, eradication of the inhibitor, complete or partial remission (CR, PR), relapse, or early death (≤30 days). Of the 29 patients in total, 22 individuals achieved CR (76%), three had PR, one relapsed, and three died within 30 days (one of acute myocardial infarction while on anti-haemorrhagic treatment, one of sepsis while on immunosuppression due to active acquired haemophilia A, one of lung bleeding in association with pre-existing pulmonary sarcoidosis). Conclusion: This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in the proportion of patients with respiratory diseases is present.

Assessing Acute St-Elevation Myocardial Infarction With Prognostic Significance Of The Hyponatramia

2020 ◽  
Vol 11 (3) ◽  
pp. 3251-3260
Author(s):  
Makrand B Mane
Keyword(s):  
Myocardial Infarction ◽  
Ejection Fraction ◽  
Tertiary Care ◽  
Prognostic Significance ◽  
Care Facility ◽  
Early Death ◽  
Public Health Issue ◽  
Care Hospital ◽  
Tertiary Care Facility ◽  
Significant Public Health

Acute Myocardial Infarction (AMI) has become a significant public health issue in developed and developing nations, following extensive diagnostic and management research over recent decades. The study intended to research the prognostic values of inexplicable Hyponatremia in patients with severe STelevation of myocardial infarction, in 100 consecutive patients admitted to Tertiary care hospital. In the analysis, identified patients on admission were diagnosed with or produced Hyponatremia within 72 hours—a lower ejection fraction than those with usual amounts of sodium. The research aimed to evaluate the prognosis significance of Hyponatremia for the estimation of early death in acute ST-elevated myocardial infarction. One hundred straight patients admitted in the Coronary Centre Tertiary Care Facility with severe STelevated myocardial infarction were studied. The data of the study on various risk factors in association with the development of Hyponatremia like as age, sex, use of tobacco, diabetes, hypertension, ejection fraction etc. were analyzed. Thus, the researchers reported that in patients diagnosed with severe ST section escalation, Hyponatremia showed the initial emergence of hyponatremia myocardial infarctions. This condition correlates with the severity of LV dysfunction (in term of LVEF) and can be considered as an individual early death indicator as well as a prediction exacerbates with hyponatremia frequency.

A Comprehensive Review on Importance and Quantitation of Atypical Antipsychotic Drugs and their Active Metabolites in Commercial Dosage Forms

2020 ◽  
Vol 16 (8) ◽  
pp. 989-1019
Author(s):  
Habibur Rahman ◽  
S.K. Manirul Haque ◽  
Masoom Raza Siddiqui
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Liquid Chromatography ◽  
Antipsychotic Drugs ◽  
Method Development ◽  
Early Death ◽  
Dosage Forms ◽  
Gas Chromatography Mass Spectrometry ◽  
Active Metabolites ◽  
Chromatography Mass Spectrometry

Background: Schizophrenia is a severe mental illness that affects more than twenty-one million people throughout the world. Schizophrenia also causes early death. Schizophrenia and other related psychotic ailments are controlled by the prescription of antipsychotic drugs, which act by blocking certain chemical receptors in the brain and thus relieves the symptoms of psychotic disorder. These drugs are present in the different dosage forms in the market and provided in a certain amount as per the need of the patients. Objective: Since such medications treat mental disorders, it is very important to have a perfect and accurate dose so that the risk factor is not affected by a higher or lower dose, which is not sufficient for the treatment. For accurate assay of these kinds of drugs, different analytical methods were developed ranging from older spectrophotometric techniques to latest hyphenated methods. Results: The current review highlights the role of different analytical techniques that were employed in the determination and identification of antipsychotic drugs and their metabolites. Techniques such as spectrophotometry, fluorimetry, liquid chromatography, liquid chromatography-mass spectrometry, gas chromatography, and gas chromatography-mass spectrometry employed in the method development of such antipsychotic drugs were reported in the review. Different metabolites, identified using the hyphenated techniques, were also mentioned in the review. The synthesis pathways of few of the metabolites were mentioned. Conclusion: The review summarizes the analyses of different antipsychotic drugs and their metabolites. A brief introduction of illnesses and their symptoms and possible medications were highlighted. Synthesis pathways of the associated metabolites were also mentioned.

The End of Outrage

2017 ◽  
Author(s):  
Breandán Mac Suibhne
Keyword(s):  
Cultural Change ◽  
Early Death

James Gallagher’s early death in 1863 helped to end outrage at his doings. So too did rapid social and cultural change in the 1860s and 1870s and the abandonment of Irish as the language of the home c.1880; the place in which Gallagher had acquired land in sordid circumstances was increasingly difficult to imagine, his individualistic values were now more common, and demographic decline had increased people’s need for their neighbours. The author’s paternal grandparents (b. 1900, 1907) were direct descendants of the two tenants who had transferred land to Gallagher in 1855. Although they did talk of Gallagher’s acquisition of land ‘in the time of the Famine’ from people believed to have been tenants, they said nothing of his eviction of subtenants.

Leonard Woolf

2019 ◽  
Author(s):  
Fred Leventhal ◽  
Peter Stansky
Keyword(s):  
Virginia Woolf ◽  
Publishing House ◽  
Early Death ◽  
International Affairs ◽  
John Maynard Keynes ◽  
Bloomsbury Group ◽  
Unusual Position ◽  
Leonard Woolf ◽  
Hogarth Press ◽  
The Village

This is a wide-ranging biography of Leonard Woolf (1880–1969), an important yet somewhat neglected figure in British life. He is in the unusual position of being overshadowed by his wife, Virginia Woolf, and his role in helping her is part of this study. He was born in London to a father who was a successful barrister but whose early death left the family in economic difficulty. Though he abandoned his Judaism when young, being Jewish was deeply significant in shaping Leonard’s ideas, as well as the Hellenism imbibed as a student at both St Paul’s and Trinity College, Cambridge. Despite his secularism, there were surprisingly spiritual dimensions to his life. At Cambridge he was a member of the secret discussion group, the Apostles, as were his friends Lytton Stracheyand John Maynard Keynes, thus becoming part of the later Bloomsbury Group. He spent seven years as a successful civil servant in Ceylon, which later enabled him to write brilliantly about empire as well as a powerful novel, The Village in the Jungle. Returning to London in 1911, he married Virginia Woolf the next year. In 1917 they founded the Hogarth Press, a successful and significant publishing house. During his long life he became a major figure, a prolific writer on a range of subjects, most importantly international affairs, especially the creation of the League of Nations, a range of domestic problems, and issues of imperialism, particularly in Africa. He was a seminal figure in twentieth-century British life.

scholarly journals La muerte del príncipe Don Juan. Exequias y duelo en Córdoba y Sevilla durante el otoño de 1497 = The Death of Prince Juan. Funeral Rites and Mourning in Cordoba and Seville during the Autumn of 1497

2018 ◽  
pp. 107
Author(s):  
Margarita Cabrera Sánchez
Keyword(s):  
Early Death ◽  
Post Mortem ◽  
Don Juan ◽  
Funeral Rites ◽  
Unpublished Information

La finalidad de este trabajo es estudiar las circunstancias de la muerte del príncipe don Juan, los ritos post mortem y las ceremonias fúnebres que tuvieron lugar en Córdoba y Sevilla. Además, nos hemos detenido a analizar cómo pudieron transcurrir los primeros años de su vida y su adolescencia, ya que los testimonios consultados revelan una salud frágil, que, probablemente, pudo precipitar su temprano fallecimiento. Las numerosas fuentes a las que hemos tenido acceso nos han permitido obtener datos inéditos sobre el ceremonial funerario, las manifestaciones de duelo y el volumen de gastos al que tuvieron que hacer frente los concejos de Córdoba y Sevilla para despedir, como la ocasión merecía, al príncipe heredero.  The purpose of this paper is to study the circumstances of the death of prince Juan, the post mortem rites and the funeral ceremonies that took place in Cordoba and Seville. In addition, we have analysed how the first years of his life and adolescence may have taken place, since the testimonies consulted reveal a fragile health that probably could have determined his early death. The numerous sources to which we have had access allowed us to obtain unpublished information on the funerary ceremonial, the demonstrations of mourning and the level of expenditure that was assumed by the councils of Cordoba and Seville to pay their last respects to the heir prince.

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