Green tea catechins as brain-permeable, non toxic iron chelators to “iron out iron” from the brain

2006 ◽  
pp. 249-257 ◽  
Author(s):  
S. Mandel ◽  
O. Weinreb ◽  
L. Reznichenko ◽  
L. Kalfon ◽  
T. Amit
Keyword(s):  
Green Tea ◽  
Iron Chelators ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
The Brain

Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders

2006 ◽  
Vol 50 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Silvia Mandel ◽  
Tamar Amit ◽  
Lydia Reznichenko ◽  
Orly Weinreb ◽  
Moussa B. H. Youdim
Keyword(s):  
Green Tea ◽  
Neurodegenerative Disorders ◽  
Iron Chelators ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Natural Iron

scholarly journals Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

2019 ◽  
Vol 20 (15) ◽  
pp. 3630 ◽  
Author(s):  
Monira Pervin ◽  
Keiko Unno ◽  
Akiko Takagaki ◽  
Mamoru Isemura ◽  
Yoriyuki Nakamura
Keyword(s):  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Systemic Circulation ◽  
Brain Parenchyma ◽  
Neuroprotective Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Ring Fission ◽  
The Brain

Over the last three decades, green tea has been studied for its beneficial effects, including anti-cancer, anti-obesity, anti-diabetes, anti-inflammatory, and neuroprotective effects. At present, a number of studies that have employed animal, human and cell cultures support the potential neuroprotective effects of green tea catechins against neurological disorders. However, the concentration of (−)-epigallocatechin gallate (EGCG) in systemic circulation is very low and EGCG disappears within several hours. EGCG undergoes microbial degradation in the small intestine and later in the large intestine, resulting in the formation of various microbial ring-fission metabolites which are detectable in the plasma and urine as free and conjugated forms. Recently, in vitro experiments suggested that EGCG and its metabolites could reach the brain parenchyma through the blood–brain barrier and induce neuritogenesis. These results suggest that metabolites of EGCG may play an important role, alongside the beneficial activities of EGCG, in reducing neurodegenerative diseases. In this review, we discuss the function of EGCG and its microbial ring-fission metabolites in the brain in suppressing brain dysfunction. Other possible actions of EGCG metabolites will also be discussed.

Green tea catechins attenuate high-fat diet effects related to obesity and diabetes without effect hypothalamic expression of TLR4 pathway or serotoninergic 1B and 2C receptors

2013 ◽  
Author(s):  
Marcos Hiromu Okuda ◽  
de Santana Aline Alves ◽  
Mayara Franzoi Moreno ◽  
Ana Claudia Hachul ◽  
Nelson Inacio Neto ◽  
...  
Keyword(s):  
Green Tea ◽  
High Fat Diet ◽  
High Fat ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Obesity And Diabetes

The Protective Effects of Green Tea Catechins in the Management of Neurodegenerative Diseases: A Review

2019 ◽  
Vol 16 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Hanieh Shaterzadeh Yazdi ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathways ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Main Role ◽  
Related Factor ◽  
Protective Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
And Control

Background: The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of this study is to review the effects of green tea catechins against the Neurodegenerative Diseases. Methods: In this study, we extensively reviewed all articles on the terms of Green tea, catechins, CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017. Results: The present study found that catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers which possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-&amp;#954;B and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Conclusion: The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.<P&gt;

Neuroprotection of green tea catechins on surgical menopause-induced overactive bladder in a rat model

2012 ◽  
Vol 19 (3) ◽  
pp. 346-354 ◽  
Author(s):  
Yung-Shun Juan ◽  
Shu-Mien Chuang ◽  
Cheng-Yu Long ◽  
Chung-Hwan Chen ◽  
Robert M. Levin ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Green Tea ◽  
Rat Model ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Surgical Menopause

scholarly journals Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4014
Author(s):  
Anchalee Rawangkan ◽  
Kirati Kengkla ◽  
Sukrit Kanchanasurakit ◽  
Acharaporn Duangjai ◽  
Surasak Saokaew
Keyword(s):  
Systematic Review ◽  
Green Tea ◽  
Viral Infections ◽  
Influenza Infection ◽  
Meta Analysis ◽  
Influenza Virus Infection ◽  
Control Group ◽  
Tea Consumption ◽  
Tea Catechins ◽  
Green Tea Catechins

Influenza is one of the most serious respiratory viral infections worldwide. Although several studies have reported that green tea catechins (GTCs) might prevent influenza virus infection, this remains controversial. We performed a systematic review and meta-analysis of eight studies with 5,048 participants that examined the effect of GTC administration on influenza prevention. In a random-effects meta-analysis of five RCTs, 884 participants treated with GTCs showed statistically significant effects on the prevention of influenza infection compared to the control group (risk ratio (RR) 0.67, 95%CIs 0.51–0.89, P = 0.005) without evidence of heterogeneity (I2= 0%, P = 0.629). Similarly, in three cohort studies with 2,223 participants treated with GTCs, there were also statistically significant effects (RR 0.52, 95%CIs 0.35–0.77, P = 0.001) with very low evidence of heterogeneity (I2 = 3%, P = 0.358). Additionally, the overall effect in the subgroup analysis of gargling and orally ingested items (taking capsules and drinking) showed a pooled RR of 0.62 (95% CIs 0.49–0.77, P = 0.003) without heterogeneity (I2= 0%, P = 0.554). There were no obvious publication biases (Egger’s test (P = 0.138) and Begg’s test (P = 0.103)). Our analysis suggests that green tea consumption is effective in the prophylaxis of influenza infections. To confirm the findings before implementation, longitudinal clinical trials with specific doses of green tea consumption are warranted.

Inhibition of adenovirus infection and adenain by green tea catechins

2003 ◽  
Vol 58 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Joseph M Weber ◽  
Angelique Ruzindana-Umunyana ◽  
Lise Imbeault ◽  
Sucheta Sircar
Keyword(s):  
Green Tea ◽  
Adenovirus Infection ◽  
Tea Catechins ◽  
Green Tea Catechins
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