Adverse Effects of Bisphenol A on Male Reproductive Function

2013 ◽  
pp. 57-82 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Rajamanickam Jubendradass ◽  
Edouard Akono Nantia ◽  
Paul Fewou Moundipa ◽  
Premendu Prakash Mathur
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function

Bisphenol A differentially affects male reproductive function biomarkers in a reference population and agro pesticides users from Djutitsa, Cameroon

2019 ◽  
Vol 35 (4) ◽  
pp. 324-335 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Cathérine Harthé ◽  
Edouard Akono Nantia ◽  
Henri Dechaud ◽  
Angèle Nkouatchoua Tchana ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Daily Intake ◽  
Reproductive Function ◽  
Reference Population ◽  
Average Concentration ◽  
Sex Hormone Binding Globulin ◽  
Urinary Concentration ◽  
Total Testosterone ◽  
Male Reproductive Function ◽  
Significant Difference

The consequences of bisphenol A (BPA) exposure on male reproductive function were studied in two populations from Cameroon, farmers using agro pesticides in Djutitsa (rural area) and townsmen in Yaoundé (urban area, Centre region). Urinary BPA concentration from all participants was measured, and the values were correlated with biochemical markers of male reproductive function. The data showed that BPA could be detected in 92.6% of urine participants, with an average concentration of 2.18 ± 1.97 µg/g creatinine but with no significant difference between the urinary BPA concentration from rural and urban populations. From BPA urinary concentration, the BPA average daily intake was estimated to be 0.06 ± 0.05 μg/kg/day (3.51 µg/day per individual) in the Cameroon population. Interestingly, free and bioavailable testosterone concentrations and estradiol/testosterone ratio correlated with BPA levels in the overall population. When data were analysed according to residence, BPA correlated with total testosterone levels ( r = −0.433) and estradiol/testosterone ratio ( r = 0.338) in the urban residents only, while the rural population exhibited significant increases in sex-hormone-binding globulin with increased BPA exposure. Our data showed that the male Cameroon population is exposed to BPA but that inconstant BPA association to endocrine reproductive markers suggests that other environmental factors in combination with BPA exposure might influence testicular function.

scholarly journals Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

2020 ◽  
Vol 21 (16) ◽  
pp. 5761 ◽  
Author(s):  
Ilaria Cimmino ◽  
Francesca Fiory ◽  
Giuseppe Perruolo ◽  
Claudia Miele ◽  
Francesco Beguinot ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Health ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Dental Materials ◽  
Reproductive Function ◽  
Epigenetic Changes ◽  
Synthetic Compound ◽  
Male Reproductive Function ◽  
Thermal Paper

Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.

scholarly journals Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen

2018 ◽  
Vol 15 (8) ◽  
pp. 1770 ◽  
Author(s):  
Youping Tian ◽  
Xiaoyu Zhou ◽  
Maohua Miao ◽  
De-kun Li ◽  
Ziliang Wang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Exposed Group ◽  
Human Semen ◽  
Linear Regression Models ◽  
Endocrine Disrupting Chemical ◽  
Dna Hydroxymethylation ◽  
Unexposed Group ◽  
Male Reproductive Function ◽  
Male Workers

Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on DNA hydroxymethylation in humans. The objective of the present study was to examine whether BPA exposure was associated with DNA hydroxymethylation in human semen samples. We measured urine BPA levels and LINE-1 hydroxymethylation in 158 male factory workers selected from an occupational cohort study conducted in China between 2004 and 2008. Among them, there were 72 male workers with occupational BPA exposure (BPA-exposed group) and 86 male workers without occupational BPA exposure (unexposed group). Multivariate linear regression models were used to examine the association of exposure to BPA with LINE-1 hydroxymethylation. LINE-1 was more highly hydroxymethylated in the BPA-exposed group than in the unexposed group (median 12.97% vs. 9.68%, respectively; p < 0.05), after adjusting for the potential confounders. The medians of 5-hydroxymethylcytosine (5hmC) generally increased with increasing urine BPA levels: 8.79%, 12.16%, 11.53%, and 13.45%, for undetected BPA and corresponding tertiles for the detected BPA, respectively. After analysis using data at individual level, our findings indicated that BPA exposure was associated with alterations of sperm LINE-1 hydroxymethylation, which might have implications for understanding the mechanisms underlying BPA-induced adverse effects on male reproductive function.

Association of Serum Bisphenol-A Concentration and Male Reproductive Function Among Exposed Workers

2014 ◽  
Vol 68 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Wanli Zhuang ◽  
Kusheng Wu ◽  
Yukai Wang ◽  
Hongjun Zhu ◽  
Zanzhang Deng ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function ◽  
Exposed Workers

The impact of antenatal Bisphenol A exposure on male reproductive function at 20–22 years of age

2018 ◽  
Vol 36 (3) ◽  
pp. 340-347 ◽  
Author(s):  
Roger J. Hart ◽  
Dorota A. Doherty ◽  
Jeffrey A. Keelan ◽  
Novia S. Minaee ◽  
Eric B. Thorstensen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function ◽  
The Impact

scholarly journals Bisphenol A as a potential hazardous compound on male reproductive function : A mini-review

2019 ◽  
Vol 9 (3) ◽  
pp. 65-70
Author(s):  
Mohamed Abd El Salam ◽  
Nada El Sayed Selim
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function
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