scholarly journals The Impact of Prenatal Exposure to Bisphenol A on Male Reproductive Function

2020 ◽  
Vol 11 ◽  
Author(s):  
Roger J. Hart
Keyword(s):  
Bisphenol A ◽  
Prenatal Exposure ◽  
Reproductive Function ◽  
Male Reproductive Function ◽  
The Impact

The impact of antenatal Bisphenol A exposure on male reproductive function at 20–22 years of age

2018 ◽  
Vol 36 (3) ◽  
pp. 340-347 ◽  
Author(s):  
Roger J. Hart ◽  
Dorota A. Doherty ◽  
Jeffrey A. Keelan ◽  
Novia S. Minaee ◽  
Eric B. Thorstensen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function ◽  
The Impact

Adverse Effects of Bisphenol A on Male Reproductive Function

2013 ◽  
pp. 57-82 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Rajamanickam Jubendradass ◽  
Edouard Akono Nantia ◽  
Paul Fewou Moundipa ◽  
Premendu Prakash Mathur
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function

Bisphenol A differentially affects male reproductive function biomarkers in a reference population and agro pesticides users from Djutitsa, Cameroon

2019 ◽  
Vol 35 (4) ◽  
pp. 324-335 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Cathérine Harthé ◽  
Edouard Akono Nantia ◽  
Henri Dechaud ◽  
Angèle Nkouatchoua Tchana ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Daily Intake ◽  
Reproductive Function ◽  
Reference Population ◽  
Average Concentration ◽  
Sex Hormone Binding Globulin ◽  
Urinary Concentration ◽  
Total Testosterone ◽  
Male Reproductive Function ◽  
Significant Difference

The consequences of bisphenol A (BPA) exposure on male reproductive function were studied in two populations from Cameroon, farmers using agro pesticides in Djutitsa (rural area) and townsmen in Yaoundé (urban area, Centre region). Urinary BPA concentration from all participants was measured, and the values were correlated with biochemical markers of male reproductive function. The data showed that BPA could be detected in 92.6% of urine participants, with an average concentration of 2.18 ± 1.97 µg/g creatinine but with no significant difference between the urinary BPA concentration from rural and urban populations. From BPA urinary concentration, the BPA average daily intake was estimated to be 0.06 ± 0.05 μg/kg/day (3.51 µg/day per individual) in the Cameroon population. Interestingly, free and bioavailable testosterone concentrations and estradiol/testosterone ratio correlated with BPA levels in the overall population. When data were analysed according to residence, BPA correlated with total testosterone levels ( r = −0.433) and estradiol/testosterone ratio ( r = 0.338) in the urban residents only, while the rural population exhibited significant increases in sex-hormone-binding globulin with increased BPA exposure. Our data showed that the male Cameroon population is exposed to BPA but that inconstant BPA association to endocrine reproductive markers suggests that other environmental factors in combination with BPA exposure might influence testicular function.

scholarly journals Chlamydial Infection and Its Role in Male Infertility

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Mary K. Samplaski ◽  
Trustin Domes ◽  
Keith A. Jarvi
Keyword(s):  
Male Fertility ◽  
Reproductive Potential ◽  
Reproductive Function ◽  
Chlamydia Infection ◽  
Sperm Dna Fragmentation ◽  
Infertile Male ◽  
Male Population ◽  
Male Reproductive Function ◽  
Infertile Men ◽  
The Impact

Introduction. Chlamydia trachomatis is an established cause of tubal factor infertility; however its role in male fertility is not as clear. We sought to determine the prevalence of Chlamydia in infertile men and evaluate its impact on male reproductive potential. Materials and Methods. We compared the incidence of Chlamydia in our infertile male population with that reported in the literature. We then reviewed the impact of Chlamydia infection on male fertility. Results. The incidence of Chlamydia infection in our population of infertile men was 0.3%. There is considerable variability in the reported incidence, likely due to variation in the population studied, and detection technique. The optimal testing method and sample are presently unclear. The effect of Chlamydia on male reproductive function is also variable in the literature, but appears to be relatively minimal and may be related primarily to sperm DNA fragmentation or female partner transmission. Conclusions. The prevalence of Chlamydia in the infertile male population is low and routine testing is not supported by the literature. For high-risk infertile men, nucleic acid testing of urine +/− semen is the most sensitive method to detect Chlamydia. A validated testing system for semen needs to be developed, so that a standardized methodology can be recommended. In this way the full implications of Chlamydia on male fertility can be elucidated.

scholarly journals Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

2020 ◽  
Vol 21 (16) ◽  
pp. 5761 ◽  
Author(s):  
Ilaria Cimmino ◽  
Francesca Fiory ◽  
Giuseppe Perruolo ◽  
Claudia Miele ◽  
Francesco Beguinot ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Health ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Dental Materials ◽  
Reproductive Function ◽  
Epigenetic Changes ◽  
Synthetic Compound ◽  
Male Reproductive Function ◽  
Thermal Paper

Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.

Assessment of male reproductive function and prevention of androgen deficiency

2020 ◽  
Vol 60 (11) ◽  
pp. 746-748
Author(s):  
P. A. Vuytsik
Keyword(s):  
Reproductive Health ◽  
Health Program ◽  
Harmful Effect ◽  
Reproductive Function ◽  
Social Significance ◽  
Reproductive Disorders ◽  
Male Reproductive Function ◽  
Human Pathology ◽  
Demographic Processes ◽  
The Impact

Introduction. Reproductive problems in marriage are an important component of demographic processes; therefore, attempts to resolve them have not only medical but also social significance. The state of male reproductive health plays an important role in demographic indicators, in particular, in population reproduction. This dictates the need to increase the volume of preventive measures, which requires early detection of reproductive disorders due to the impact of environmental factors, including occupational ones, that have a harmful effect on men. The aim of the study is to develop a prevention program aimed at preserving and improving the reproductive health of employees engaged in harmful working conditions. Materials and methods. To predict the quality of health of a future individual, it is necessary to consider many risk factors that can participate in the development of human pathology. Methods for studying reproductive health disorders in men include both conventional, classical methods of examining men by urologists, andrologists, and expert ones, which allow us to find out the role of harmful factors in the development of reproductive disorders of professional etiology by specialists in occupational medicine. The implementation of a reproductive health program requires monitoring the progress of the actions taken and evaluating their effectiveness. Results. Implementing a reproductive health program requires monitoring the progress of actions and evaluating their effectiveness. Conclusions. The ability to assess the risk of damage to reproductive health and the health of the offspring makes it possible to manage this risk, to prevent and reduce the levels of occupationally determined morbidity and morbidity associated with exposure to harmful factors.

Same Total Normal Forms Sperm Counts of Males From Lhasa and Shanghai, China

2021 ◽  
Author(s):  
Benhong GU ◽  
Shangren WANG ◽  
Feng LIU ◽  
Yuxuan SONG ◽  
Jun LI ◽  
...  
Keyword(s):  
Normal Form ◽  
Sperm Concentration ◽  
Reproductive Function ◽  
Sperm Parameters ◽  
Semen Parameters ◽  
Male Reproductive Function ◽  
Fragmentation Index ◽  
Reproductive Endocrine ◽  
Index Ratio ◽  
The Impact

Abstract Male infertility may be caused by genetic and/or environmental factors that impair spermatogenesis and sperm maturation. High-altitude (HA) hypoxic environments represent one of the most serious challenges faced by humans that reside in these areas. To assess the influence of the plateau environment on semen parameters, 2,798 males, including 1,111 native Tibetans and 1,687 Han Chinese individuals living in the plains(HCILP) who underwent pre-pregnancy checkups, were enrolled in this study. The semen samples of males were evaluated to determine conventional sperm parameters, sperm morphology, and sperm movement. Reproductive endocrine hormones (REHs) were detected in 474 males, including 221 Tibetans and 253 HCILP. Due to recurrent abortions in partners, the DNA fragmentation index (DFI) of 133 native Tibetans and 393 HCILP individuals was further compared. Luteinizing hormone (LH) (4.94 ± 2.12 vs. 3.29 ± 1.43 U/L), prolactin (11.34 ± 3.87 vs. 8.97 ± 3.48 nmol/L), E2/T (0.22 ± 0.11 vs 0.11 ± 0.05), median total sperm motility (61.20% vs. 51.56%), and DFI (23.11% vs. 7.22%) were higher in males from plateau areas while median progressive motility (PR) (35.60% vs. 41.12%), total number of PR sperms (51.61 vs. 59.63 mil/ejaculate), percentage of normal form sperms (3.70% vs. 6.00%), curvilinear velocity (36.10 vs. 48.97 μm/s), straight-line (rectilinear) velocity (14.70 vs. 31.52 μm/s), estradiol (103.82 ± 45.92 vs. 146.01 ± 39.73 pmol/L), progesterone (0.29 ± 0.27 vs. 2.22 ± 0.84 nmol/L), testosterone (4.90 ± 1.96 vs. 14.36 ± 5.24 nmol/L), and testosterone secretion index (ratio of testosterone to LH) (33.45 ± 22.86 vs 145.78 ± 73.41) were lower than those in males from the plains. There was no difference in median total sperm number (157.76 vs. 151.65 mil/mL), sperm concentration (52.40 vs. 51.79 mil/mL), volume (3.10 vs. 3.10 mL), total normal form sperms (5.91 vs. 6.58 mil/ejaculate, p50), and follicle-stimulating hormone (FSH) levels (4.13 ± 2.55 U/L vs 3.82 ± 2.35 U/L) between the two groups of males. The REH and sperm parameters of males from HA hypoxic environments were adaptively altered. Although the total number of PR sperm decreased and DFI increased, the Tibetan population that lives at HAs has been found to grown continuously and rapidly. These results supplement prior findings regarding the impact of HA on male reproductive function.

Can Antidiabetic Drugs Improve Male Reproductive (Dys)Function Associated with Diabetes?

2019 ◽  
Vol 26 (22) ◽  
pp. 4191-4222 ◽  
Author(s):  
R.S. Tavares ◽  
S. Escada-Rebelo ◽  
M.I. Sousa ◽  
A. Silva ◽  
J. Ramalho-Santos ◽  
...  
Keyword(s):  
Diabetes Management ◽  
Reproductive Function ◽  
Experimental Models ◽  
Antidiabetic Drugs ◽  
Therapeutic Interventions ◽  
Diabetic Patients ◽  
Dipeptidyl Peptidase 4 ◽  
Bile Acid Sequestrants ◽  
Male Reproductive Function ◽  
The Impact

The alarming increase in the number of diabetic patients worldwide raises concerns regarding the impact of the disease on global health, not to mention on social and economic aspects. Furthermore, the association of this complex metabolic disorder with male reproductive impairment is worrying, mainly due to the increasing chances that young individuals, at the apex of their reproductive window, could be affected by the disease, further contributing to the disturbing decline in male fertility worldwide. The cornerstone of diabetes management is glycemic control, proven to be effective in avoiding, minimizing or preventing the appearance or development of disease-related complications. Nonetheless, the possible impact of these therapeutic interventions on male reproductive function is essentially unexplored. To address this issue, we have made a critical assessment of the literature on the effects of several antidiabetic drugs on male reproductive function. While the crucial role of insulin is clear, as shown by the recovery of reproductive impairments in insulin-deficient individuals after treatment, the same clearly does not apply to other antidiabetic strategies. In fact, there is an abundance of controversial reports, possibly related to the various study designs, experimental models and compounds used, which include biguanides, sulfonylureas, meglitinides, thiazolidinediones/glitazones, bile acid sequestrants, amylin mimetics, as well as sodiumglucose co-transporter 2 (SGLT2) inhibitors, glucagon-like peptide 1 (GLP1), α-glucosidase inhibitors and dipeptidyl peptidase 4 (DPP4) inhibitors. These aspects constitute the focus of the current review.

scholarly journals Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen

2018 ◽  
Vol 15 (8) ◽  
pp. 1770 ◽  
Author(s):  
Youping Tian ◽  
Xiaoyu Zhou ◽  
Maohua Miao ◽  
De-kun Li ◽  
Ziliang Wang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Exposed Group ◽  
Human Semen ◽  
Linear Regression Models ◽  
Endocrine Disrupting Chemical ◽  
Dna Hydroxymethylation ◽  
Unexposed Group ◽  
Male Reproductive Function ◽  
Male Workers

Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on DNA hydroxymethylation in humans. The objective of the present study was to examine whether BPA exposure was associated with DNA hydroxymethylation in human semen samples. We measured urine BPA levels and LINE-1 hydroxymethylation in 158 male factory workers selected from an occupational cohort study conducted in China between 2004 and 2008. Among them, there were 72 male workers with occupational BPA exposure (BPA-exposed group) and 86 male workers without occupational BPA exposure (unexposed group). Multivariate linear regression models were used to examine the association of exposure to BPA with LINE-1 hydroxymethylation. LINE-1 was more highly hydroxymethylated in the BPA-exposed group than in the unexposed group (median 12.97% vs. 9.68%, respectively; p < 0.05), after adjusting for the potential confounders. The medians of 5-hydroxymethylcytosine (5hmC) generally increased with increasing urine BPA levels: 8.79%, 12.16%, 11.53%, and 13.45%, for undetected BPA and corresponding tertiles for the detected BPA, respectively. After analysis using data at individual level, our findings indicated that BPA exposure was associated with alterations of sperm LINE-1 hydroxymethylation, which might have implications for understanding the mechanisms underlying BPA-induced adverse effects on male reproductive function.

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