scholarly journals Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen

2018 ◽  
Vol 15 (8) ◽  
pp. 1770 ◽  
Author(s):  
Youping Tian ◽  
Xiaoyu Zhou ◽  
Maohua Miao ◽  
De-kun Li ◽  
Ziliang Wang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Exposed Group ◽  
Human Semen ◽  
Linear Regression Models ◽  
Endocrine Disrupting Chemical ◽  
Dna Hydroxymethylation ◽  
Unexposed Group ◽  
Male Reproductive Function ◽  
Male Workers

Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on DNA hydroxymethylation in humans. The objective of the present study was to examine whether BPA exposure was associated with DNA hydroxymethylation in human semen samples. We measured urine BPA levels and LINE-1 hydroxymethylation in 158 male factory workers selected from an occupational cohort study conducted in China between 2004 and 2008. Among them, there were 72 male workers with occupational BPA exposure (BPA-exposed group) and 86 male workers without occupational BPA exposure (unexposed group). Multivariate linear regression models were used to examine the association of exposure to BPA with LINE-1 hydroxymethylation. LINE-1 was more highly hydroxymethylated in the BPA-exposed group than in the unexposed group (median 12.97% vs. 9.68%, respectively; p < 0.05), after adjusting for the potential confounders. The medians of 5-hydroxymethylcytosine (5hmC) generally increased with increasing urine BPA levels: 8.79%, 12.16%, 11.53%, and 13.45%, for undetected BPA and corresponding tertiles for the detected BPA, respectively. After analysis using data at individual level, our findings indicated that BPA exposure was associated with alterations of sperm LINE-1 hydroxymethylation, which might have implications for understanding the mechanisms underlying BPA-induced adverse effects on male reproductive function.

Adverse Effects of Bisphenol A on Male Reproductive Function

2013 ◽  
pp. 57-82 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Rajamanickam Jubendradass ◽  
Edouard Akono Nantia ◽  
Paul Fewou Moundipa ◽  
Premendu Prakash Mathur
Keyword(s):  
Adverse Effects ◽  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function

Bisphenol A differentially affects male reproductive function biomarkers in a reference population and agro pesticides users from Djutitsa, Cameroon

2019 ◽  
Vol 35 (4) ◽  
pp. 324-335 ◽  
Author(s):  
Faustin Pascal Tsagué Manfo ◽  
Cathérine Harthé ◽  
Edouard Akono Nantia ◽  
Henri Dechaud ◽  
Angèle Nkouatchoua Tchana ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Daily Intake ◽  
Reproductive Function ◽  
Reference Population ◽  
Average Concentration ◽  
Sex Hormone Binding Globulin ◽  
Urinary Concentration ◽  
Total Testosterone ◽  
Male Reproductive Function ◽  
Significant Difference

The consequences of bisphenol A (BPA) exposure on male reproductive function were studied in two populations from Cameroon, farmers using agro pesticides in Djutitsa (rural area) and townsmen in Yaoundé (urban area, Centre region). Urinary BPA concentration from all participants was measured, and the values were correlated with biochemical markers of male reproductive function. The data showed that BPA could be detected in 92.6% of urine participants, with an average concentration of 2.18 ± 1.97 µg/g creatinine but with no significant difference between the urinary BPA concentration from rural and urban populations. From BPA urinary concentration, the BPA average daily intake was estimated to be 0.06 ± 0.05 μg/kg/day (3.51 µg/day per individual) in the Cameroon population. Interestingly, free and bioavailable testosterone concentrations and estradiol/testosterone ratio correlated with BPA levels in the overall population. When data were analysed according to residence, BPA correlated with total testosterone levels ( r = −0.433) and estradiol/testosterone ratio ( r = 0.338) in the urban residents only, while the rural population exhibited significant increases in sex-hormone-binding globulin with increased BPA exposure. Our data showed that the male Cameroon population is exposed to BPA but that inconstant BPA association to endocrine reproductive markers suggests that other environmental factors in combination with BPA exposure might influence testicular function.

scholarly journals Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes

2019 ◽  
Vol 20 (20) ◽  
pp. 5003 ◽  
Author(s):  
Isabel Forner-Piquer ◽  
Ioannis Fakriadis ◽  
Constantinos C Mylonas ◽  
Fabiana Piscitelli ◽  
Vincenzo Di Marzo ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Leptin Receptor ◽  
Sparus Aurata ◽  
Gonadosomatic Index ◽  
Endocannabinoid System ◽  
Reproductive Function ◽  
High Plasma ◽  
Gilthead Sea Bream ◽  
Sea Bream ◽  
Endocrine Disrupting Chemical

Bisphenol A (BPA), a known endocrine disrupting chemical (EDC), was administered by diet to gilthead sea bream (Sparus aurata) in order to study its effects on the endocannabinoid system (ECS) and gonadal steroidogenesis. 2-year-old male gilthead sea bream were fed with two different concentrations of BPA (LOW at 4 and HIGH at 4000 µg/kg body weight for 21 days during the reproductive season. Exposure to 4000 µg BPA/kg bw/day (BPA HIGH) reduced sperm motility and altered the straight-line velocity (VSL) and linearity (LIN). Effects on steroidogenesis were evident, with testosterone (T) being up-regulated by both treatments and 11-ketotestosterone (11-KT) down-regulated by BPA HIGH. Plasma levels of 17β-estradiol (E2) were not affected. The Gonadosomatic Index (GSI) increased in the BPA HIGH group. Interestingly, the levels of endocannabinoids and endocannabinoid-like compounds were significantly reduced after both treatments. Unpredictably, a few changes were noticed in the expression of genes coding for ECS enzymes, while the receptors were up-regulated depending on the BPA dose. Reproductive markers in testis (leptin receptor (lepr), estrogen receptors (era, erb), progesterone receptors (pr) and the gonadotropin releasing hormone receptor (gnrhr)) were up-regulated. BPA induced the up-regulation of the hepatic genes involved in oogenesis (vitellogenin (vtg) and zona pellucida 1 (zp1)).

scholarly journals Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

2020 ◽  
Vol 21 (16) ◽  
pp. 5761 ◽  
Author(s):  
Ilaria Cimmino ◽  
Francesca Fiory ◽  
Giuseppe Perruolo ◽  
Claudia Miele ◽  
Francesco Beguinot ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Health ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Dental Materials ◽  
Reproductive Function ◽  
Epigenetic Changes ◽  
Synthetic Compound ◽  
Male Reproductive Function ◽  
Thermal Paper

Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.

scholarly journals Associations of COVID-19 lockdown with gestational length and preterm birth in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Moran Dong ◽  
Rui Qian ◽  
Jiaqi Wang ◽  
Jingjie Fan ◽  
Yufeng Ye ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Medical Records ◽  
Exposed Group ◽  
Cumulative Exposure ◽  
Linear Regression Models ◽  
Gestational Length ◽  
Unexposed Group ◽  
Gestational Week ◽  
Level I ◽  
Different Levels

Abstract Background The effects of COVID-19 lockdown measures on maternal and fetal health remain unclear. We examined the associations of COVID-19 lockdown with gestational length and preterm birth (PTB) in a Chinese population. Methods We obtained medical records of 595,396 singleton live infants born between 2015 and 2020 in 5 cities in Guangdong Province, South China. The exposed group (N = 101,900) included women who experienced the COVID-19 Level I lockdown (1/23–2/24/2020) during pregnancy, while the unexposed group (N = 493,496) included women who were pregnant during the same calendar months in 2015–2019. Cumulative exposure was calculated based on days exposed to different levels of emergency responses with different weighting. Generalized linear regression models were applied to estimate the associations of lockdown exposure with gestational length and risk of PTB (< 37 weeks). Results The exposed group had a shorter mean gestational length than the unexposed group (38.66 vs 38.74 weeks: adjusted β = − 0.06 week [95%CI, − 0.07, − 0.05 week]). The exposed group also had a higher risk of PTB (5.7% vs 5.3%; adjusted OR = 1.08 [95%CI, 1.05, 1.11]). These associations seemed to be stronger when exposure occurred before or during the 23rd gestational week (GW) than during or after the 24th GW. Similarly, higher cumulative lockdown exposure was associated with a shorter gestational length and a higher risk of PTB. Conclusions The COVID-19 lockdown measures were associated with a slightly shorter gestational length and a moderately higher risk of PTB. Early and middle pregnancy periods may be a more susceptible exposure window.

scholarly journals Associations of COVID-19 Lockdown with Gestational Length and Preterm Birth in China

2021 ◽  
Author(s):  
Moran Dong ◽  
Rui Qian ◽  
Jiaqi Wang ◽  
Jingjie Fan ◽  
Yufeng Ye ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Medical Records ◽  
Exposed Group ◽  
Cumulative Exposure ◽  
Linear Regression Models ◽  
Gestational Length ◽  
Unexposed Group ◽  
Gestational Week ◽  
Level I ◽  
Different Levels

Abstract BackgroundThe effects of COVID-19 lockdown measures on maternal and fetal health remain unclear. We examined the associations of COVID-19 lockdown with gestational length and preterm birth (PTB) in a Chinese population.MethodsWe obtained medical records of 595396 singleton live infants born between 2015 and 2020 in 5 cities in Guangdong Province, South China. The exposed group (N=101900) included women who experienced the COVID-19 Level I lockdown (1/23-2/24/2020) during pregnancy, while the unexposed group (N=493496) included women who were pregnant during the same calendar months in 2015-2019. Cumulative exposure was calculated based on days exposed to different levels of emergency responses with different weighting. Generalized linear regression models were applied to estimate the associations of lockdown exposure with gestational length and risk of PTB (<37 weeks).ResultsThe exposed group had a shorter mean gestational length than the unexposed group (38.66 vs 38.74 weeks: adjusted β=-0.06 week [95%CI, -0.07, -0.05 week]). The exposed group also had a higher risk of PTB (5.7% vs 5.3%; adjusted OR=1.08 [95%CI, 1.05, 1.11]). These associations seemed to be stronger when exposure occurred before or during the 23rd gestational week (GW) than during or after the 24th GW. Similarly, higher cumulative lockdown exposure was associated with a shorter gestational length and a higher risk of PTB.ConclusionsThe COVID-19 lockdown measures were associated with a slightly shorter gestational length and a moderately higher risk of PTB. Early and middle pregnancy periods may be a more susceptible exposure window.

scholarly journals Estrogen-Like Disruptive Effects of Dietary Exposure to Bisphenol A or 17α-Ethinyl Estradiol in CD1 Mice

2012 ◽  
Vol 31 (6) ◽  
pp. 537-550 ◽  
Author(s):  
Eric L. Kendig ◽  
Dana R. Buesing ◽  
Susie M. Christie ◽  
Clifford J. Cookman ◽  
Robin B. Gear ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Ethinyl Estradiol ◽  
Reproductive Function ◽  
Dietary Exposure ◽  
Female Offspring ◽  
High Dose ◽  
Metabolic Function ◽  
Endocrine Disrupting Chemical ◽  
Response Characteristics ◽  
Cd1 Mice

Bisphenol A (BPA) is an endocrine disrupting chemical that is ubiquitous in wild and built environments. Due to variability in study design, the disruptive effects of BPA have proven difficult to experimentally replicate. This study was designed to assess the disruptive actions of dietary BPA exposure, while carefully controlling for known confounders. Parental CD1 mice were acclimated to defined diet containing BPA (0.03, 0.3, 3, 30, or 300 ppm) or 17α-ethinyl estradiol (EE; 0.0001, 0.001, and 0.01 ppm) and bred to produce progeny (F1) that were maintained through adulthood on the same diet as the parents. In F1 females, uterine weights were increased in all EE and the 30-ppm BPA-exposure groups, demonstrating model sensitivity and estrogen-like actions of BPA. In BPA-exposed females, no treatment-related differences were observed in parental reproductive function, or in the timing of puberty and metabolic function in female offspring. In F1 males, modest changes in body weight, adiposity  and glucose tolerance, consistent with improved metabolic function, were observed. Associated with increased prolactin and increased circulating testosterone levels, balanopreputial separation was accelerated by 0.03 and 3.0 ppm BPA and anogenital distance at postnatal day 21 was increased in males by 0.03 ppm BPA. Sperm counts were also increased with 3.0 ppm BPA exposures. Overall, BPA was found to have modest, sex specific endocrine disruptive effects on a variety of end points below the established no observed adverse effect level. The dose response characteristics for many of the effects were nonmonotonic and not predictable from high-dose extrapolations.

Association of Serum Bisphenol-A Concentration and Male Reproductive Function Among Exposed Workers

2014 ◽  
Vol 68 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Wanli Zhuang ◽  
Kusheng Wu ◽  
Yukai Wang ◽  
Hongjun Zhu ◽  
Zanzhang Deng ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Reproductive Function ◽  
Male Reproductive Function ◽  
Exposed Workers
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