What is the Status of the Hardy-Weinberg Law within Population Genetics?

Author(s):  
Pablo Lorenzano
2012 ◽  
Vol 7 (4) ◽  
pp. 346-357 ◽  
Author(s):  
Roberta L. Millstein

2019 ◽  
Vol 45 (6) ◽  
pp. 1119-1141
Author(s):  
Venla Oikkonen

The study of ancient DNA (aDNA) has gained increasing attention in science and society as a tool for tracing hominin evolution. While aDNA research overlaps with the history of population genetics, it embodies a specific configuration of technology, temporality, temperature, and place that, this article suggests, cannot be fully unpacked with existing science and technology studies approaches to population genetics. This article explores this configuration through the 2010 discovery of the Denisovan hominin based on aDNA retrieved from a finger bone and tooth in Siberia. The analysis explores how the Denisovan was enacted as a technoscientific object through the cool and even temperatures of Denisova Cave, assumptions about the connection between individual and population, the status of populations as evolutionary entities, and underlying colonialist and imperialist imaginaries of Siberia and Melanesia. The analysis sheds light on how aDNA research is changing the parameters within which evolutionary history is imagined and conceptualized. Through the case study, it also outlines some ways in which the specific technoscientific and cultural entanglements of aDNA can be critically explored.


Author(s):  
Lindley Darden

Genetics studies the problem of heredity, namely why offspring resemble their parents. The field emerged in 1900 with the rediscovery of the 1865 work of Gregor Mendel. William Bateson called the new field ‘genetics’ in 1905, and W. Johannsen used the term ‘gene’ in 1909. By analysing data about patterns of inheritance of characters, such as yellow and green peas, Mendelian geneticists infer the number and type of hypothetical genes. The major components of the theory of the gene, which proposed the model of genes as beads on a string, were in place by the 1920s. In the 1930s, the field of population genetics emerged from the synthesis of results from Mendelian genetics with Darwinian natural selection. Population geneticists study the distribution of genes in the gene pool of a population and changes caused by selection and other factors. The 1940s and 1950s saw the development of molecular genetics, which investigates problems about gene reproduction, mutation and function at the molecular level. Philosophical issues arise: the question about the evidence for the reality of hypothetical genes, and the status of Mendel’s laws, given that they are not universal generalizations. Debates have occurred about the nature of the relation between Mendelian and molecular genetics. Population genetics provides the perspective of the gene as the unit of selection in evolutionary theory. Molecular genetics and its accompanying technologies raise ethical issues about humans’ genetic information, such as the issue of privacy of information about one’s genome and the morality of changing a person’s genes. The nature–nurture debate involves the issue of genetic determinism, the extent to which genes control human traits and behaviour.


Author(s):  
L.J. Chen ◽  
Y.F. Hsieh

One measure of the maturity of a device technology is the ease and reliability of applying contact metallurgy. Compared to metal contact of silicon, the status of GaAs metallization is still at its primitive stage. With the advent of GaAs MESFET and integrated circuits, very stringent requirements were placed on their metal contacts. During the past few years, extensive researches have been conducted in the area of Au-Ge-Ni in order to lower contact resistances and improve uniformity. In this paper, we report the results of TEM study of interfacial reactions between Ni and GaAs as part of the attempt to understand the role of nickel in Au-Ge-Ni contact of GaAs.N-type, Si-doped, (001) oriented GaAs wafers, 15 mil in thickness, were grown by gradient-freeze method. Nickel thin films, 300Å in thickness, were e-gun deposited on GaAs wafers. The samples were then annealed in dry N2 in a 3-zone diffusion furnace at temperatures 200°C - 600°C for 5-180 minutes. Thin foils for TEM examinations were prepared by chemical polishing from the GaA.s side. TEM investigations were performed with JE0L- 100B and JE0L-200CX electron microscopes.


Author(s):  
Frank J. Longo

Measurement of the egg's electrical activity, the fertilization potential or the activation current (in voltage clamped eggs), provides a means of detecting the earliest perceivable response of the egg to the fertilizing sperm. By using the electrical physiological record as a “real time” indicator of the instant of electrical continuity between the gametes, eggs can be inseminated with sperm at lower, more physiological densities, thereby assuring that only one sperm interacts with the egg. Integrating techniques of intracellular electrophysiological recording, video-imaging, and electron microscopy, we are able to identify the fertilizing sperm precisely and correlate the status of gamete organelles with the first indication (fertilization potential/activation current) of the egg's response to the attached sperm. Hence, this integrated system provides improved temporal and spatial resolution of morphological changes at the site of gamete interaction, under a variety of experimental conditions. Using these integrated techniques, we have investigated when sperm-egg plasma membrane fusion occurs in sea urchins with respect to the onset of the egg's change in electrical activity.


2000 ◽  
Vol 64 (11) ◽  
pp. 772-774 ◽  
Author(s):  
JG Odom ◽  
PL Beemsterboer ◽  
TD Pate ◽  
NK Haden

2002 ◽  
Vol 110 (2) ◽  
pp. 9-15 ◽  
Author(s):  
W Freedman
Keyword(s):  

1998 ◽  
Vol 14 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Richard H. Dana

This paper describes the status of multicultural assessment training, research, and practice in the United States. Racism, politicization of issues, and demands for equity in assessment of psychopathology and personality description have created a climate of controversy. Some sources of bias provide an introduction to major assessment issues including service delivery, moderator variables, modifications of standard tests, development of culture-specific tests, personality theory and cultural/racial identity description, cultural formulations for psychiatric diagnosis, and use of findings, particularly in therapeutic assessment. An assessment-intervention model summarizes this paper and suggests dimensions that compel practitioners to ask questions meriting research attention and providing avenues for developments of culturally competent practice.


1962 ◽  
Vol 7 (4) ◽  
pp. 156-156
Author(s):  
C. SHAGASS

1990 ◽  
Vol 35 (10) ◽  
pp. 982-983
Author(s):  
Gail M. Williamson
Keyword(s):  

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