Mechanisms of Damage and Failure

2014 ◽  
pp. 85-120
Author(s):  
Jose Luis Otegui
Keyword(s):  
Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2554
Author(s):  
Marc Micó-Carnero ◽  
Araní Casillas-Ramírez ◽  
Albert Caballeria-Casals ◽  
Carlos Rojano-Alfonso ◽  
Alfredo Sánchez-González ◽  
...  

Herein, we investigate whether: (1) the administration of glucose or a lipid emulsion is useful in liver transplantation (LT) using steatotic (induced genetically or nutritionally) or non-steatotic livers from donors after brain death (DBDs); and (2) any such benefits are due to reductions in intestinal damage and consequently to gut microbiota preservation. In recipients from DBDs, we show increased hepatic damage and failure in the maintenance of ATP, glycogen, phospholipid and growth factor (HGF, IGF1 and VEGFA) levels, compared to recipients from non-DBDs. In recipients of non-steatotic grafts from DBDs, the administration of glucose or lipids did not protect against hepatic damage. This was associated with unchanged ATP, glycogen, phospholipid and growth factor levels. However, the administration of lipids in steatotic grafts from DBDs protected against damage and ATP and glycogen drop and increased phospholipid levels. This was associated with increases in growth factors. In all recipients from DBDs, intestinal inflammation and damage (evaluated by LPS, vascular permeability, mucosal damage, TLR4, TNF, IL1, IL-10, MPO, MDA and edema formation) was not shown. In such cases, potential changes in gut microbiota would not be relevant since neither inflammation nor damage was evidenced in the intestine following LT in any of the groups evaluated. In conclusion, lipid treatment is the preferable nutritional support to protect against hepatic damage in steatotic LT from DBDs; the benefits were independent of alterations in the recipient intestine.


2021 ◽  
Vol 42 (4) ◽  
pp. 1912-1944
Author(s):  
Ya Wang ◽  
Zhen‐Guo Liu ◽  
Yun‐Peng Yi ◽  
Yu‐Chen Wei ◽  
Zhi‐jian Li ◽  
...  

2020 ◽  
Vol 97 ◽  
pp. 102479 ◽  
Author(s):  
Ioannis Katsivalis ◽  
Ole Thybo Thomsen ◽  
Stefanie Feih ◽  
Mithila Achintha

Author(s):  
Thomas Christiner ◽  
Johannes Reiser ◽  
István Gódor ◽  
Wilfried Eichlseder ◽  
Franz Trieb ◽  
...  

In many assemblies of moving components, contact problems under various lubrication conditions are lifetime-limiting. There, relative motion of contacting bodies, combined with high loads transmitted via the contact surface lead to fretting fatigue failure. For a reliable prediction of in service performance load type, different damage and failure mechanisms that may be activated during operation have to be known. In this contribution selected results of a currently conducted research project are presented. The aim of this study was to examine the material behaviour of a surface stressed steel. The influence of the fretting regime on fatigue properties has been investigated.


1993 ◽  
Vol 03 (C7) ◽  
pp. C7-123-C7-126
Author(s):  
E. R. SCHIAPPARELLI ◽  
S. C. PRADO
Keyword(s):  

2011 ◽  
Vol 70 ◽  
pp. 87-92 ◽  
Author(s):  
Shao Peng Ma ◽  
Dong Yan ◽  
Xian Wang ◽  
Yan Yan Cao

Observation of damage evolution is of great importance to the understanding of the failure process of rock materials. High-speed DIC system is constructed and used to observe the strain field evolution of the granodiorite disc in Brazilian test. The strain fields at different load levels are analyzed based on the stain abnormality indicator (SAI) which is the ratio of the strain measured in experiment to the strain from theoretical solution in an isotropy and elastic model. SAI could be used to indicate the damage in the specimen. The process of damage and failure of the specimen in Brazilian disc test is quantitatively analyzed and deeply discussed according to the strain fields and the statistics of SAI. Experimental results in this paper show that the failure process of the disc specimen in Brazilian test is not simple crack propagation under tensile load, but a complicated damage evolution procedure.


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