Lichen Secondary Metabolites as Possible Antiviral Agents

2014 ◽  
pp. 165-177 ◽  
Author(s):  
Damian C. Odimegwu ◽  
Chika Ejikeugwu ◽  
Charles C. Esimone
Keyword(s):  
Secondary Metabolites ◽  
Antiviral Agents

scholarly journals Secondary Metabolites from Caulerpa Cylindracea (Sonder) Could Be Alternative Natural Antiviral Compounds for COVID-19: A Further in Silico Proof

2020 ◽  
Author(s):  
Levent Çavaş ◽  
Cengizhan Dag ◽  
Miguel Carmena-Barreño ◽  
Carlos Martínez-Cortés ◽  
José Pedro Cerón-Carrasco ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Vaccine Development ◽  
Antiviral Agents ◽  
Binding Energies ◽  
Antiviral Compounds ◽  
Main Protease ◽  
The Us ◽  
The World ◽  
Molecular Dynamics Results ◽  
Spreading Property

<p>SARS-CoV-2 has been exhibiting extremely spreading property all around the world since its existence from Wuhan-China in December-2019. Although it has caused a death toll of over than 1.3 M people, no validated vaccine has been proposed yet. On the other hand, very dense studies on the vaccine development have been carrying out in some countries such as the US, Germany, UK, China and Russia. Due to side effects of current antiviral agents used in the therapy of COVID-19, there is a great need for the development of alternative compounds for this disease. Caulerpin (CPN) and caulerpenyne (CYN), predominant natural secondary metabolites from invasive marine green algae <i>Caulerpa cylindracea,</i>are proposed to neutralize the virus from two targets: spike protein (5XLR) and main protease (6YB7) in this study. The results show that the binding energies related to CPN-6YB7 and CYN-6YB7 interactions are found to be -8.02 kcal/mol and -6.83 kcal/mol, respectively. The binding energies were -9.68 kcal/mol and -7.53 kcal/mol, respectively, for CPN-5XLR and CYN-5XLR. In the molecular dynamics results, RMSD values show that CPN and CYN can form stable complexes with the proteins where CYN is more stable with 6YB7 and CPN interacts better with 5XLR. These differences seem to be based on the type of interactions of the complexes. In conclusion, caulerpin and caulerpenyne can further be investigated experimentally for their anti-SARS-CoV-2 efficiency. </p>

scholarly journals Secondary Metabolites from Caulerpa Cylindracea (Sonder) Could Be Alternative Natural Antiviral Compounds for COVID-19: A Further in Silico Proof

2020 ◽  
Author(s):  
Levent Çavaş ◽  
Cengizhan Dag ◽  
Miguel Carmena-Bargueño ◽  
Carlos Martínez-Cortés ◽  
José Pedro Cerón-Carrasco ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Vaccine Development ◽  
Antiviral Agents ◽  
Binding Energies ◽  
Antiviral Compounds ◽  
Main Protease ◽  
The Us ◽  
The World ◽  
Molecular Dynamics Results ◽  
Spreading Property

<p>SARS-CoV-2 has been exhibiting extremely spreading property all around the world since its existence from Wuhan-China in December-2019. Although it has caused a death toll of over than 1.3 M people, no validated vaccine has been proposed yet. On the other hand, very dense studies on the vaccine development have been carrying out in some countries such as the US, Germany, UK, China and Russia. Due to side effects of current antiviral agents used in the therapy of COVID-19, there is a great need for the development of alternative compounds for this disease. Caulerpin (CPN) and caulerpenyne (CYN), predominant natural secondary metabolites from invasive marine green algae <i>Caulerpa cylindracea,</i>are proposed to neutralize the virus from two targets: spike protein (5XLR) and main protease (6YB7) in this study. The results show that the binding energies related to CPN-6YB7 and CYN-6YB7 interactions are found to be -8.02 kcal/mol and -6.83 kcal/mol, respectively. The binding energies were -9.68 kcal/mol and -7.53 kcal/mol, respectively, for CPN-5XLR and CYN-5XLR. In the molecular dynamics results, RMSD values show that CPN and CYN can form stable complexes with the proteins where CYN is more stable with 6YB7 and CPN interacts better with 5XLR. These differences seem to be based on the type of interactions of the complexes. In conclusion, caulerpin and caulerpenyne can further be investigated experimentally for their anti-SARS-CoV-2 efficiency. </p>

Lichen Secondary Metabolites as Possible Antiviral Agents

2019 ◽  
pp. 199-214
Author(s):  
Damian C. Odimegwu ◽  
Kenneth Ngwoke ◽  
Chika Ejikeugwu ◽  
Charles O. Esimone
Keyword(s):  
Secondary Metabolites ◽  
Antiviral Agents

scholarly journals Secondary Metabolites from Caulerpa Cylindracea (Sonder) Could Be Alternative Natural Antiviral Compounds for COVID-19: A Further in Silico Proof

2020 ◽  
Author(s):  
Levent Çavaş ◽  
Cengizhan Dag ◽  
Miguel Carmena-Bargueño ◽  
Carlos Martínez-Cortés ◽  
José Pedro Cerón-Carrasco ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Vaccine Development ◽  
Antiviral Agents ◽  
Binding Energies ◽  
Antiviral Compounds ◽  
Main Protease ◽  
The Us ◽  
The World ◽  
Molecular Dynamics Results ◽  
Spreading Property

<p>SARS-CoV-2 has been exhibiting extremely spreading property all around the world since its existence from Wuhan-China in December-2019. Although it has caused a death toll of over than 1.3 M people, no validated vaccine has been proposed yet. On the other hand, very dense studies on the vaccine development have been carrying out in some countries such as the US, Germany, UK, China and Russia. Due to side effects of current antiviral agents used in the therapy of COVID-19, there is a great need for the development of alternative compounds for this disease. Caulerpin (CPN) and caulerpenyne (CYN), predominant natural secondary metabolites from invasive marine green algae <i>Caulerpa cylindracea,</i>are proposed to neutralize the virus from two targets: spike protein (5XLR) and main protease (6YB7) in this study. The results show that the binding energies related to CPN-6YB7 and CYN-6YB7 interactions are found to be -8.02 kcal/mol and -6.83 kcal/mol, respectively. The binding energies were -9.68 kcal/mol and -7.53 kcal/mol, respectively, for CPN-5XLR and CYN-5XLR. In the molecular dynamics results, RMSD values show that CPN and CYN can form stable complexes with the proteins where CYN is more stable with 6YB7 and CPN interacts better with 5XLR. These differences seem to be based on the type of interactions of the complexes. In conclusion, caulerpin and caulerpenyne can further be investigated experimentally for their anti-SARS-CoV-2 efficiency. </p>

Recent Advances in the Discovery of Antiviral Metabolites from Fungi

2021 ◽  
Vol 22 ◽  
Author(s):  
Sunil K. Deshmukh ◽  
Shivankar Agrawal ◽  
Manish Kumar Gupta ◽  
Rajesh K. Patidar ◽  
Nihar Ranjan
Keyword(s):  
Secondary Metabolites ◽  
Treatment Options ◽  
Antiviral Agents ◽  
Antiviral Drugs ◽  
Plant Diseases ◽  
Dna And Rna ◽  
Global Pandemic ◽  
Wide Range ◽  
New Compounds ◽  
The Impact

: As the world manages the impact of a global pandemic caused by COVID-19, the discovery of new antiviral agents has become way more relevant and urgent. Viruses are submicroscopic infectious agents that replicate inside the living cells of different organisms. These viruses use nucleic acids (both DNA and RNA) for further replication and maturity inside the cells. Some of the viruses responsible for various human and plant diseases belong to the classes of Picornaviridae, Retroviridae, Orthomyxoviridae, Flaviviridae, Pneumoviridae, Virgaviridae, and Hepadnaviridae, and their treatment options are limited or non-existent. The consistent reemergence and resistance development in the viral strains demands the discovery and development of new antiviral drugs possessing better efficacy. Bio-active compounds isolated from fungi can be the source of new compounds with enhanced potency and new mechanisms of action. Fungi are known to produce a diverse lot of secondary metabolites due to their existence in harsh climates which are often inhabitable for many organisms. Due to these unique environments, fungi produce a variety of secondary metabolites of different chemical classes like alkaloids, quinones, furanone, pyrones, benzopyranoids, xanthones, terpenes, steroids, peptides, and many acyclic compounds. Fungal metabolites are known to display a wide range of bioactive attributes, i.e., anticancer, antibacterial, antifungal, and anti-Alzheimer's, along with antiviral properties. In this review article, we report over 300 antiviral compounds from fungal sources during the period of 2009 to 2019. The source of these compounds is marine and endophytic fungi and they are arranged based on their antiviral action against different viral families. These compounds are promising in their use and development as future antiviral drugs.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

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