Effects of Taurine Supplementation on Adipose Tissue of Obese Trained Rats

2015 ◽  
pp. 707-714 ◽  
Author(s):  
Ana Carolina de Almeida Martiniano ◽  
Flávia Giolo De Carvalho ◽  
Júlio Sérgio Marchini ◽  
Sérgio Britto Garcia ◽  
Jorge Elias Júnior ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Taurine Supplementation

scholarly journals Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 688 ◽  
Author(s):  
Kyoung Soo Kim ◽  
Hari Madhuri Doss ◽  
Hee-Jin Kim ◽  
Hyung-In Yang
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
High Fat Diet ◽  
Fat Deposition ◽  
Chow Diet ◽  
Fat Tissue ◽  
High Fat ◽  
Taurine Supplementation ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose

This study was conducted to investigate if taurine supplementation stimulates the induction of thermogenic genes in fat tissues and muscles and decipher the mechanism by which taurine exerts its anti-obesity effect in a mildly obese ICR (CD-1®) mouse model. Three groups of ICR mice were fed a normal chow diet, a high-fat diet (HFD), or HFD supplemented with 2% taurine in drinking water for 28 weeks. The expression profiles of various genes were analyzed by real time PCR in interscapular brown adipose tissue (BAT), inguinal white adipose tissue (iWAT), and the quadriceps muscles of the experimental groups. Genes that are known to regulate thermogenesis like PGC-1α, UCP-1, Cox7a1, Cox8b, CIDE-A, and β1-, β2-, and β3-adrenergic receptors (β-ARs) were found to be differentially expressed in the three tissues. These genes were expressed at a very low level in iWAT as compared to BAT and muscle. Whereas, HFD increased the expression of these genes. Taurine supplementation stimulated the expression of UCP-1, Cox7a1, and Cox8b in BAT and only Cox7a1 in muscle, while there was a decrease in iWAT. In contrast, fat deposition-related genes, monoamine oxidases (MAO)-A, and -B, and lipin-1, were decreased by taurine supplementation only in iWAT and not in BAT or muscle. In conclusion, the potential anti-obesity effects of taurine may be partly due to upregulated thermogenesis in BAT, energy metabolism of muscle, and downregulated fat deposition in iWAT.

Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women

Amino Acids ◽  
2021 ◽  
Author(s):  
Flavia Giolo De Carvalho ◽  
Camila Fernanda Cunha Brandao ◽  
Vitor Rosetto Muñoz ◽  
Gabriela Batitucci ◽  
Maria Eduarda de Almeida Tavares ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Obese Women ◽  
Taurine Supplementation ◽  
Subcutaneous White Adipose Tissue

Long-term effects of a maternal high-fat: high-fructose diet on offspring growth and metabolism and impact of maternal taurine supplementation

2019 ◽  
Vol 11 (4) ◽  
pp. 419-426 ◽  
Author(s):  
M. Li ◽  
C. M. Reynolds ◽  
C. Gray ◽  
R. Patel ◽  
D. M. Sloboda ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Maternal Obesity ◽  
Maternal Diet ◽  
Control Diet ◽  
Well Being ◽  
Oral Glucose ◽  
Long Term Effects ◽  
High Fat ◽  
Taurine Supplementation ◽  
Maternal Undernutrition

AbstractObjective:Maternal obesity is associated with obesity and metabolic disorders in offspring. However, there remains a paucity of data on strategies to reverse the effects of maternal obesity on maternal and offspring health. With maternal undernutrition, taurine supplementation improves outcomes in offspring mediated in part via improved glucose–insulin homeostasis. The efficacy of taurine supplementation in the setting of maternal obesity on health and well-being of offspring is unknown. We examined the effects of taurine supplementation on outcomes related to growth and metabolism in offspring in a rat model of maternal obesity.Design:Wistar rats were randomised to: 1) control diet during pregnancy and lactation (CON); 2) CON with 1.5% taurine in drinking water (CT); 3) maternal obesogenic diet (MO); or 4) MO with taurine (MOT). Offspring were weaned onto the control diet for the remainder of the study.Results:At day 150, offspring body weights and adipose tissue weights were increased in MO groups compared to CON. Adipose tissue weights were reduced in MOT versus MO males but not females. Plasma fasting leptin and insulin were increased in MO offspring groups but were not altered by maternal taurine supplementation. Plasma homocysteine concentrations were reduced in all maternal taurine-supplemented offspring groups. There were significant interactions across maternal diet, taurine supplementation and sex for response to an oral glucose tolerance test , a high-fat dietary preference test and pubertal onset in offspring.Conclusions:These results demonstrate that maternal taurine supplementation can partially ameliorate adverse developmental programming effects in offspring in a sex-specific manner.

Taurine supplementation regulates Iκ-Bα protein expression in adipose tissue and serum IL-4 and TNF-α concentrations in MSG obesity

2015 ◽  
Vol 56 (2) ◽  
pp. 705-713 ◽  
Author(s):  
Luiz Carlos Caetano ◽  
Maria Lúcia Bonfleur ◽  
Rosane Aparecida Ribeiro ◽  
Tarlliza Romanna Nardelli ◽  
Camila Lubaczeuski ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Protein Expression ◽  
Taurine Supplementation ◽  
Tnf Α

scholarly journals Taurine (2-Aminoethanesulfonic Acid) Deficiency Creates a Vicious Circle Promoting Obesity

Endocrinology ◽  
2006 ◽  
Vol 147 (7) ◽  
pp. 3276-3284 ◽  
Author(s):  
Nobuyo Tsuboyama-Kasaoka ◽  
Chikako Shozawa ◽  
Kayo Sano ◽  
Yasutomi Kamei ◽  
Seiichi Kasaoka ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
De Novo ◽  
Resting Energy Expenditure ◽  
The Body ◽  
Vicious Circle ◽  
High Fat ◽  
Taurine Supplementation ◽  
Taurine Deficiency

The relation between blood taurine (2-aminoethanesulfonic acid) concentrations and obesity was investigated. Taurine is supplied to the body by dietary ingestion as well as by de novo synthesis; it is anabolized by cysteine dioxygenase (CDO), which is abundantly expressed in liver and white adipose tissue. Overexpression of CDO in 3T3-L1 preadipocytes caused a decrease in the level of cysteine (precursor of taurine) and an increase in the level of taurine in the culture medium, suggesting that CDO is involved in biosynthesis and secretion of taurine in white adipose tissue. In high-fat diet-induced and/or genetically obese mice, a decrease in the blood taurine concentration was observed along with a decrease in CDO expression in adipose tissue but not in liver. Dietary taurine supplementation prevented high-fat diet-induced obesity with increased resting energy expenditure. Thus, taurine deficiency observed in association with obesity may create a vicious circle promoting obesity. Dietary taurine supplementation interrupts this vicious circle and may prevent obesity.

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