Transependymal Movement of Cerebrospinal Fluid in Neurological and Psychiatric Pathological Conditions

2016 ◽  
pp. 295-300
Author(s):  
Svadovsky Alexander
Keyword(s):  
Cerebrospinal Fluid ◽  
Pathological Conditions

Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions

2016 ◽  
Vol 33 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Masaki Ueno ◽  
Yoichi Chiba ◽  
Ryuta Murakami ◽  
Koichi Matsumoto ◽  
Machi Kawauchi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Pathological Conditions ◽  
Blood Brain

EM.P.2.02 Secretion of the N-terminal domain of α-dystroglycan in the human cerebrospinal fluid in physiological and pathological conditions

2009 ◽  
Vol 19 (8-9) ◽  
pp. 552
Author(s):  
K. Matsumura ◽  
F. Saito ◽  
Y. Saito-Arai ◽  
M. Ikeda ◽  
A. Nakakmura ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Terminal Domain ◽  
Pathological Conditions ◽  
Human Cerebrospinal Fluid

scholarly journals New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?

2004 ◽  
Vol 379 (1) ◽  
pp. 119-124 ◽  
Author(s):  
André B. P. van KUILENBURG ◽  
Alida E. M. STROOMER ◽  
Henk van LENTHE ◽  
Nico G. G. M. ABELING ◽  
Albert H. van GENNIP
Keyword(s):  
Cerebrospinal Fluid ◽  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Degradation Pathway ◽  
Aminoisobutyric Acid ◽  
Pathological Conditions ◽  
Pyrimidine Bases ◽  
The Mean ◽  
Pyrimidine Degradation ◽  
Mean Concentration

DPD (dihydropyrimidine dehydrogenase) constitutes the first step of the pyrimidine degradation pathway, in which the pyrimidine bases uracil and thymine are catabolized to β-alanine and the R-enantiomer of β-AIB (β-aminoisobutyric acid) respectively. The S-enantiomer of β-AIB is predominantly derived from the catabolism of valine. It has been suggested that an altered homoeostasis of β-alanine underlies some of the clinical abnormalities encountered in patients with a DPD deficiency. In the present study, we demonstrated that only a slightly decreased concentration of β-alanine was present in the urine and plasma, whereas normal levels of β-alanine were present in the cerebrospinal fluid of patients with a DPD deficiency. Therefore the metabolism of β-alanine-containing peptides, such as carnosine, may be an important factor involved in the homoeostasis of β-alanine in patients with DPD deficiency. The mean concentration of β-AIB was approx. 2–3-fold lower in cerebrospinal fluid and urine of patients with a DPD deficiency, when compared with controls. In contrast, strongly decreased levels (10-fold) of β-AIB were present in the plasma of DPD patients. Our results demonstrate that, under pathological conditions, the catabolism of valine can result in the production of significant amounts of β-AIB. Furthermore, the observation that the R-enantiomer of β-AIB is abundantly present in the urine of DPD patients suggests that significant cross-over exists between the thymine and valine catabolic pathways.

scholarly journals Cerebrospinal fluid dynamics with its surgical implications

2020 ◽  
pp. 459-462
Author(s):  
Harold E. Vasquez ◽  
Yeider A. Durango-Espinosa ◽  
Ezequiel Garcia-Ballestas ◽  
B.V. Murlimanju ◽  
Andrei Fernandes Joaquim ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Cerebrospinal Fluid ◽  
Review Article ◽  
Cerebrospinal Fluid Dynamics ◽  
Outflow Resistance ◽  
Csf Pressure ◽  
Pathological Conditions ◽  
Pressure Dynamics ◽  
Csf Physiology ◽  
Plasma Ultrafiltrate

Cerebrospinal fluid (CSF) is largely (70-80%) produced by the choroids plexus of the ventricles and is considered as the plasma ultrafiltrate. While CSF formation, circulation, and composition appear to be physiological and physical, its absorption appears to be mainly physical. The formation, composition, circulation, absorption, and changes in pathological conditions of CSF are discussed briefly in this review article. The CSF pressure dynamics studies provide information about the tightness, elastance, or outflow resistance of the CSF in the CNS. We believe that the present study shall help to provide essential details of CSF physiology which are important to many disciplines including radiology, neurology, and neurosurgery.

Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis

2018 ◽  
Vol 25 (11) ◽  
pp. 1535-1538 ◽  
Author(s):  
Nicolas Fissolo ◽  
Laura Cervera-Carles ◽  
Luisa María Villar Guimerans ◽  
Alberto Lleó ◽  
Jordi Clarimón ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Mitochondrial Dna ◽  
Clinically Isolated Syndrome ◽  
Chain Reaction ◽  
Pathological Conditions ◽  
Polymerase Chain ◽  
Digital Polymerase Chain Reaction

The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls. These findings do not support the determination of CSF mtDNA levels as a useful biomarker in MS clinical practice.

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