Correlated Maps for Regional Multi-Hazard Analysis: Ideas for a Novel Approach

2016 ◽  
pp. 15-39 ◽  
Author(s):  
Paolo Bocchini ◽  
Vasileios Christou ◽  
Manuel J. Miranda
Keyword(s):  
Hazard Analysis ◽  
Novel Approach

High-Resolution Seismic Hazard Analysis in a Complex Geological Configuration: The Case of the Sulmona Basin in Central Italy

2014 ◽  
Vol 30 (4) ◽  
pp. 1801-1824 ◽  
Author(s):  
Manuela Villani ◽  
Ezio Faccioli ◽  
Mario Ordaz ◽  
Marco Stupazzini
Keyword(s):  
High Resolution ◽  
Seismic Hazard ◽  
Ground Motion ◽  
Hazard Analysis ◽  
Near Field ◽  
Central Italy ◽  
Three Dimensional ◽  
Spectral Element ◽  
Seismic Wave Propagation ◽  
Novel Approach

This work proposes a novel approach for probabilistic seismic hazard analyses (PSHA) in the near field of active earthquake faults, in which deterministically computed ground motion scenarios, replacing empirically predicted ground motion values, are introduced. In fact, the databases of most ground motion prediction equations (GMPEs) tend to be insufficiently constrained at short distances and data may only partially account for the rupture process, seismic wave propagation and three-dimensional (3-D) complex configurations. Hence, herein, 3-D numerical simulations of a Mw = 6.4 earthquake rupture of the Sulmona fault in Central Italy, are carried out through the spectral element code GeoELSE ( f < 2.5 Hz), and the results are introduced in a PSHA, exploiting the capabilities of CRISIS2008 code. The SH results obtained highlight the combined effects of site, basin, and topographic features, and provide a “high-resolution” representation of the hazard in the Sulmona Basin, particularly at long periods. Such representation is expected to be more realistic than those based simply on a GMPE.

scholarly journals A novel real-time safety level calculation approach based on STPA

2020 ◽  
Vol 314 ◽  
pp. 01001
Author(s):  
Apostolos Zeleskidis ◽  
Ioannis M. Dokas ◽  
Basil Papadopoulos
Keyword(s):  
Real Time ◽  
Hazard Analysis ◽  
Reaction Times ◽  
Future Research ◽  
Critical Systems ◽  
Safety Level ◽  
Real Time System ◽  
Novel Approach ◽  
New Perspective ◽  
Level Calculation

This paper proposes a novel approach to dynamic safety level calculation for safety-critical systems based on the STAMP accident model and the implementation of a mathematical model. The proposed approach utilises (1) an STPA hazard analysis applied to the system in question, (2) system operational data from domain experts regarding process duration and reaction times, and (3) real-time system data. The STPA analysis is transformed into acyclic diagrams that graphically indicate every possible sequence of safety constraint violations that could lead to a loss (path). Based on this diagram the safety level (SL) of a system is defined as $ {\rm{SL}} = {\overrightarrow {\rm{p}} _w} $ where $ {\overrightarrow {\rm{p}} _w} $ is the most detrimental to safety path which is active for any possible time value or context in the system’s operation. This approach is also demonstrated using as a case study the “classical” Train Door STPA analysis example. This paper aims to introduce a new perspective on the problem of measuring and managing the actual safety level of highly complex socio-technical systems in real time and discusses related limitations and future research opportunities of this approach.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach

Food Safety Security: A new Concept for Enhancing Food Safety Measures

2012 ◽  
Vol 82 (3) ◽  
pp. 216-222 ◽  
Author(s):  
Venkatesh Iyengar ◽  
Ibrahim Elmadfa
Keyword(s):  
Food Safety ◽  
Hazard Analysis ◽  
Warning System ◽  
Shared Responsibility ◽  
Fine Tuning ◽  
Strategic Action ◽  
Surveillance Network ◽  
Measurement Systems ◽  
Critical Control Points ◽  
The Impact

The food safety security (FSS) concept is perceived as an early warning system for minimizing food safety (FS) breaches, and it functions in conjunction with existing FS measures. Essentially, the function of FS and FSS measures can be visualized in two parts: (i) the FS preventive measures as actions taken at the stem level, and (ii) the FSS interventions as actions taken at the root level, to enhance the impact of the implemented safety steps. In practice, along with FS, FSS also draws its support from (i) legislative directives and regulatory measures for enforcing verifiable, timely, and effective compliance; (ii) measurement systems in place for sustained quality assurance; and (iii) shared responsibility to ensure cohesion among all the stakeholders namely, policy makers, regulators, food producers, processors and distributors, and consumers. However, the functional framework of FSS differs from that of FS by way of: (i) retooling the vulnerable segments of the preventive features of existing FS measures; (ii) fine-tuning response systems to efficiently preempt the FS breaches; (iii) building a long-term nutrient and toxicant surveillance network based on validated measurement systems functioning in real time; (iv) focusing on crisp, clear, and correct communication that resonates among all the stakeholders; and (v) developing inter-disciplinary human resources to meet ever-increasing FS challenges. Important determinants of FSS include: (i) strengthening international dialogue for refining regulatory reforms and addressing emerging risks; (ii) developing innovative and strategic action points for intervention {in addition to Hazard Analysis and Critical Control Points (HACCP) procedures]; and (iii) introducing additional science-based tools such as metrology-based measurement systems.

Sign in / Sign up

Export Citation Format

Share Document