Mindfulness-Based Cognitive Therapy Improves Depression Symptoms After Traumatic Brain Injury

2016 ◽  
pp. 31-45
Author(s):  
Lana J. Ozen ◽  
Carrie Gibbons ◽  
Michel Bédard
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Therapy ◽  
Depression Symptoms

Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers

2012 ◽  
Vol 201 (3) ◽  
pp. 186-192 ◽  
Author(s):  
Jennifer J. Vasterling ◽  
Kevin Brailey ◽  
Susan P. Proctor ◽  
Robert Kane ◽  
Timothy Heeren ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Functional Impairment ◽  
Stress Disorder ◽  
Psychiatric Symptoms ◽  
Depression Symptoms ◽  
Post Traumatic Stress ◽  
Us Army ◽  
Before And After ◽  
Army Soldiers

BackgroundTraumatic brain injury (TBI) is a concern of contemporary military deployments. Whether milder TBI leads to enduring impairment remains controversial.AimsTo determine the influence of deployment TBI, and posttraumatic stress disorder (PTSD) and depression symptoms on neuropsychological and functional outcomes.MethodA sample of 760 US Army soldiers were assessed pre- and post-deployment. Outcomes included neuropsychological performances and subjective functional impairment.ResultsIn total, 9% of the participants reported (predominantly mild) TBI with loss of consciousness between pre- and post-deployment. At post-deployment, 17.6% of individuals with TBI screened positive for PTSD and 31.3% screened positive for depression. Before and after adjustment for psychiatric symptoms, TBI was significantly associated only with functional impairment. Both PTSD and depression symptoms adjusted for TBI were significantly associated with several neuropsychological performance deficits and functional impairment.ConclusionsMilder TBI reported by deployed service members typically has limited lasting neuropsychological consequences; PTSD and depression are associated with more enduring cognitive compromise.

Mindfulness Interventions Improve Depression Symptoms After Traumatic Brain Injury: Are Individual Changes Clinically Significant?

Mindfulness ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1356-1364 ◽  
Author(s):  
Lana J. Ozen ◽  
Sacha Dubois ◽  
Carrie Gibbons ◽  
Megan M. Short ◽  
Hillary Maxwell ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Depression Symptoms ◽  
Mindfulness Interventions ◽  
Clinically Significant

scholarly journals Exosomal neurofilament light

Neurology ◽  
2020 ◽  
Vol 94 (23) ◽  
pp. e2412-e2423 ◽  
Author(s):  
Vivian A. Guedes ◽  
Kimbra Kenney ◽  
Pashtun Shahim ◽  
Bao-Xi Qu ◽  
Chen Lai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Plasma Levels ◽  
Depression Symptoms ◽  
Neurofilament Light ◽  
Tnf Α ◽  
Ultrasensitive Assay ◽  
Postconcussive Syndrome ◽  
History Of ◽  
Endothelial Growth Factor

ObjectiveTo measure exosomal and plasma levels of candidate blood biomarkers in veterans with history of mild traumatic brain injury (mTBI) and test their relationship with chronic symptoms.MethodsExosomal and plasma levels of neurofilament light (NfL) chain, tumor necrosis factor (TNF)–α, interleukin (IL)–6, IL-10, and vascular endothelial growth factor (VEGF) were measured using an ultrasensitive assay in a cohort of 195 veterans, enrolled in the Chronic Effects of Neurotrauma Consortium Longitudinal Study. We examined relationships between candidate biomarkers and symptoms of postconcussive syndrome (PCS), posttraumatic stress disorder (PTSD), and depression. Biomarker levels were compared among those with no traumatic brain injury (TBI) (controls), 1–2 mTBIs, and repetitive (3 or more) mTBIs.ResultsElevated exosomal and plasma levels of NfL were associated with repetitive mTBIs and with chronic PCS, PTSD, and depression symptoms. Plasma TNF-α levels correlated with PCS and PTSD symptoms. The total number of mTBIs correlated with exosomal and plasma NfL levels and plasma IL-6. Increased number of years since the most recent TBI correlated with higher exosomal NfL and lower plasma IL-6 levels, while increased number of years since first TBI correlated with higher levels of exosomal and plasma NfL, as well as plasma TNF-α and VEGF.ConclusionRepetitive mTBIs are associated with elevated exosomal and plasma levels of NfL, even years following these injuries, with the greatest elevations in those with chronic PCS, PTSD, and depression symptoms. Our results suggest a possible neuroinflammatory and axonal disruptive basis for symptoms that persist years after mTBI, especially repetitive.

Identifying Frequency of Mild Traumatic Brain Injury in Firefighters

2020 ◽  
Vol 68 (10) ◽  
pp. 468-475 ◽  
Author(s):  
Victoria A. Torres ◽  
Jordan E. Strack ◽  
Sara Dolan ◽  
Marc I. Kruse ◽  
Michelle L. Pennington ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Assessment Tool ◽  
Head Injuries ◽  
Cross Sectional Study ◽  
Depression Symptoms ◽  
State University ◽  
Cross Sectional ◽  
Increased Risk

Background: Mild traumatic brain injury (mTBI) is a nationwide problem; yet, no firefighter mTBI data are available. Methods: In this cross-sectional study, we assessed retrospective head injuries using WHO guidelines. We captured mTBI frequency and examined firefighters’ symptoms (e.g., using Ohio State University Traumatic Brain Injury Identification method, Brief Traumatic Brain Injury Screen, Warrior Administered Retrospective Causality Assessment Tool). Findings: Of 1,112 firefighters contacted, 60 responses were included. Most participants were White (80%), male (90%), former athletes (75%). 62% met mTBI symptom criteria. 75% reported at least one lifetime head injury. Number of head injuries and depression symptoms were associated (r = .36, p < .05). Conclusion/application to practice: Overall, it appears most firefighters have sustained at least one lifetime mTBI. Those with multiple head injuries may be at increased risk of depression. Occupational health professionals should be aware of firefighters’ mTBI risk. Further research is warranted given findings.

scholarly journals Caregivers of Adults With Traumatic Brain Injury: The Emotional Impact of Transition From Hospital to Home

2010 ◽  
Vol 11 (3) ◽  
pp. 281-292 ◽  
Author(s):  
Ben Turner ◽  
Jennifer Fleming ◽  
Julie Parry ◽  
Monique Vromans ◽  
Petrea Cornwell ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Patient Discharge ◽  
Caregiver Strain ◽  
Depression Symptoms ◽  
Post Discharge ◽  
Caregiver Support ◽  
Time Points ◽  
Hospital To Home

AbstractPrimary Objective:To explore levels of depression, anxiety, stress and strain symptomatology experienced by caregivers of adults with traumatic brain injury (TBI) during the phase of transition from hospital to home.Research Design: Prospective study with data collected at three time-points: pre-discharge, 1-month post-discharge, and 3-months post-discharge.Methods and Procedures: Twenty-nine caregivers of adults with TBI (mean age 48 years), recruited on patient discharge from rehabilitation, completed the Caregiver Strain Index and the Depression, Anxiety and Stress Scale at the three time points.Results: Pairedttests showed significantly lower levels of caregiver strain at one month compared to pre-discharge, and significantly less strain and depression symptoms at 3-month follow-up compared to pre-discharge. Non-significant reductions were observed in level of stress and anxiety across the follow-up time points. Independent groupttests found that female caregivers experienced greater strain than male caregivers at 3 months post-discharge, and caregivers who were immediate family members of the patient experienced greater anxiety than those who were spouses/partners of the patient at 1-month follow-up.Conclusions: The rate of depressive symptoms in caregivers of people with TBI was greater than the general population, and strain was prevalent during the transition period. The results suggest more specific caregiver support and preparation is needed before patient discharge from hospital, and that adequate time spent in rehabilitation is beneficial for caregiver wellbeing.

Efficacy of motivational interviewing and cognitive behavioral therapy for anxiety and depression symptoms following traumatic brain injury

2015 ◽  
Vol 46 (5) ◽  
pp. 1079-1090 ◽  
Author(s):  
J. Ponsford ◽  
N. K. Lee ◽  
D. Wong ◽  
A. McKay ◽  
K. Haines ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Behavioral Therapy ◽  
Motivational Interviewing ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Secondary Outcome ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Booster Sessions

BackgroundAnxiety and depression are common following traumatic brain injury (TBI), often co-occurring. This study evaluated the efficacy of a 9-week cognitive behavioral therapy (CBT) program in reducing anxiety and depression and whether a three-session motivational interviewing (MI) preparatory intervention increased treatment response.MethodA randomized parallel three-group design was employed. Following diagnosis of anxiety and/or depression using the Structured Clinical Interview for DSM-IV, 75 participants with mild-severe TBI (mean age 42.2 years, mean post-traumatic amnesia 22 days) were randomly assigned to an Adapted CBT group: (1) MI + CBT (n = 26), or (2) non-directive counseling (NDC) + CBT (n = 26); or a (3) waitlist control (WC, n = 23) group. Groups did not differ in baseline demographics, injury severity, anxiety or depression. MI and CBT interventions were guided by manuals adapted for individuals with TBI. Three CBT booster sessions were provided at week 21 to intervention groups.ResultsUsing intention-to-treat analyses, random-effects regressions controlling for baseline scores revealed that Adapted CBT groups (MI + CBT and NDC + CBT) showed significantly greater reduction in anxiety on the Hospital Anxiety and Depression Scale [95% confidence interval (CI) −2.07 to −0.06] and depression on the Depression Anxiety and Stress Scale (95% CI −5.61 to −0.12) (primary outcomes), and greater gains in psychosocial functioning on Sydney Psychosocial Reintegration Scale (95% CI 0.04–3.69) (secondary outcome) over 30 weeks post-baseline relative to WC. The group receiving MI + CBT did not show greater gains than the group receiving NDC + CBT.ConclusionsFindings suggest that modified CBT with booster sessions over extended periods may alleviate anxiety and depression following TBI.

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