Potential Role of Endophytes in Sustainable Agriculture-Recent Developments and Future Prospects

2017 ◽  
pp. 145-169 ◽  
Author(s):  
Pranay Jain ◽  
Ram Kumar Pundir
Keyword(s):  
Sustainable Agriculture ◽  
Potential Role ◽  
Future Prospects ◽  
Recent Developments

scholarly journals Push and pull: the potential role of boron in N2 activation

2018 ◽  
Vol 47 (31) ◽  
pp. 10377-10381 ◽  
Author(s):  
Adam J. Ruddy ◽  
Darren M. C. Ould ◽  
Paul D. Newman ◽  
Rebecca L. Melen
Keyword(s):  
Potential Role ◽  
Main Group ◽  
Main Group Chemistry ◽  
Recent Developments ◽  
Push And Pull ◽  
N2 Activation

Recent developments in main group chemistry towards the activation and conversion of N2 have lead to the revelation that boron can greatly affect these processes.

scholarly journals Pathology of Gastrointestinal Stromal Tumors

2012 ◽  
Vol 5 ◽  
pp. CPath.S9689 ◽  
Author(s):  
Wai Chin Foo ◽  
Bernadette Liegl-Atzwanger ◽  
Alexander J. Lazar
Keyword(s):  
Potential Role ◽  
Soft Tissue Tumor ◽  
Kinase Inhibitors ◽  
Immunohistochemical Detection ◽  
Stromal Tumors ◽  
Activating Mutations ◽  
Receptor Kinases ◽  
Recent Developments ◽  
Immunohistochemical Diagnosis

Gastrointestinal stromal tumor (GIST) is a well recognized and relatively well understood soft tissue tumor. Early events in GIST development are activating mutations in KIT or PDGFRA, which occur in most GISTs and encode for mutated tyrosine receptor kinases that are therapeutic targets for tyrosine kinase inhibitors, including imatinib and sunitinib. A small minority of GISTs possessing neither KIT nor PDGFRA mutations may have germline mutations in SDH, suggesting a potential role of SDH in the pathogenesis. Immunohistochemical detection of KIT, and more recently DOG1, has proven to be reliable and useful in the diagnosis of GISTs. Because current and future therapies depend on pathologists, it is important that they recognize KIT-negative GISTs, GISTs in specific clinical contexts, GISTs with unusual morphology, and GISTs after treatment. This review focuses on recent developments in the understanding of the biology, immunohistochemical diagnosis, the role of molecular analysis, and risk assessment of GISTs.

scholarly journals Prebiotics to manage the microbial control of energy homeostasis

2011 ◽  
Vol 2 (4) ◽  
pp. 305-318 ◽  
Author(s):  
C. Grootaert ◽  
M. Marzorati ◽  
P. Van den Abbeele ◽  
T. Van de Wiele ◽  
S. Possemiers
Keyword(s):  
Metabolic Disorders ◽  
Energy Homeostasis ◽  
Potential Role ◽  
Microbial Control ◽  
Future Prospects ◽  
Metabolic Potential ◽  
Host Health ◽  
Prevalence Of Obesity ◽  
New Strategies

The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial community associated to the human host in controlling and influencing the energy homeostasis. According to the concept of Gastrointestinal Resource Management, this microbiota and its metabolic potential can be steered with the aim of improving host health. This review therefore focuses on the modulation of the intestinal microbiota through prebiotics with the aim to control several aspects of metabolic homeostasis. In a first part, the importance of host-microbe cross-talk at the intestinal epithelium is discussed. Yet, energy metabolism, which includes both lipid and glucose metabolism, is also regulated by several key organs including the adipose tissue, brain, liver, muscles, pancreas and gut. Therefore, in a second part, we will discuss the microbial factors that are involved in the communication between these different tissues, and their potential management. Finally, we will give some future prospects of the use of prebiotics in an individualised treatment of metabolic disorders.

How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?

2020 ◽  
Vol 48 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Alyson Ashe
Keyword(s):  
Histone Modifications ◽  
Molecular Mechanisms ◽  
Epigenetic Inheritance ◽  
Nematode Caenorhabditis Elegans ◽  
Histone Methyltransferases ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Recent Developments ◽  
Gene Regulatory

Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful in investigating the underlying molecular mechanisms of this phenomenon. In C. elegans and other animals, the modification of histone proteins has emerged as a potential carrier and effector of transgenerational epigenetic information. In this review, we explore the contribution of histone modifications to TEI in C. elegans. We describe the role of repressive histone marks, histone methyltransferases, and associated chromatin factors in heritable gene silencing, and discuss recent developments and unanswered questions in how these factors integrate with other known TEI mechanisms. We also review the transgenerational effects of the manipulation of histone modifications on germline health and longevity.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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