The Future Prospect of Targeted Therapy in Hepatocellular Carcinoma

The interest in renewable energy to replace fossil fuel is increasing as the problem caused by climate change become more severe. Small hydropower (SHP) is evaluated as a resource with high development value because of its high energy density compared to other renewable energy sources. SHP may be an attractive and sustainable power generation environmental perspective because of its potential to be found in small rivers and streams. The power generation potential could be estimated based on the discharge in the river basin. Since the river discharge depends on the climate conditions, the hydropower generation potential changes sensitively according to climate variability. Therefore, it is necessary to analyze the SHP potential in consideration of future climate change. In this study, the future prospect of SHP potential is simulated for the period of 2021 to 2100 considering the climate change in three hydropower plants of Deoksong, Hanseok, and Socheon stations, Korea. As the results, SHP potential for the near future (2021 to 2040) shows a tendency to be increased and the highest increase is 23.4% at the Deoksong SPH plant. Through the result of future prospect, we have shown that hydroelectric power generation capacity or SHP potential will be increased in the future. Therefore, we believe that it is necessary to revitalize the development of SHP in order to expand the use of renewable energy. Also, a methodology presented in this study could be used for the future prospect of the small hydropower potential.

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How to assess the efficacy or failure of targeted therapy: Deciding when to stop sorafenib in hepatocellular carcinoma

World Journal of Hepatology ◽

10.4254/wjh.v8.i35.1541 ◽

2016 ◽

Vol 8 (35) ◽

pp. 1541 ◽

Cited By ~ 6

Author(s):

Jean-Luc Raoul ◽

Xavier Adhoute ◽

Marine Gilabert ◽

Julien Edeline

Keyword(s):

Hepatocellular Carcinoma ◽

Targeted Therapy

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Progress in practical hydrogen production and utilisation in East Asia

HKIE Transactions ◽

10.33430/v28n2thie-2020-0047 ◽

2021 ◽

Vol 28 (2) ◽

pp. 88-101

Author(s):

Pradipto Suwidji ◽

Hoi Ying Chung ◽

Yun Hau Ng

Keyword(s):

South Korea ◽

East Asia ◽

Technology Development ◽

Future Prospect ◽

Pilot Projects ◽

Energy Applications ◽

Hydrogen Technology ◽

The Future ◽

The Usa ◽

East Asia Region

Development of hydrogen utilisation for energy applications has seen promising innovation towards the future prospect of clean and sustainable energy, benefitting various aspects of environmental, social, industrial and energy security. In the APEC region, several economies, such as the USA, China, Australia, Japan and South Korea, have shown interest in the development of hydrogen technology for energy applications. These economies have been devoting effort towards research and development programmes, pilot projects and, up to a certain point, implementing it in their communities. In addition, these economies each have their own tailored hydrogen roadmap or strategy, ensuring a smoother path towards hydrogen development. In this mini-review, we analysed the approaches of three selected economies in the East Asia region towards hydrogen technology, namely China, Japan and South Korea. Each of these economies have their own strategies and priorities towards the application, production and future development of hydrogen technology. This review also analyses the future possibilities for the integration of hydrogen technology into various sectors, as well as various constraints faced by each economy. Therefore, the review might serve as a valuable reference towards the feasibility of future hydrogen technology development in the East Asia and APEC region.

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Therapeutic response monitoring after targeted therapy in an orthotopic rat model of hepatocellular carcinoma using contrast-enhanced ultrasound: Focusing on inter-scanner, and inter-operator reproducibility

PLoS ONE ◽

10.1371/journal.pone.0244304 ◽

2020 ◽

Vol 15 (12) ◽

pp. e0244304

Author(s):

Hwaseong Ryu ◽

Jung Hoon Kim ◽

Seunghyun Lee ◽

Joon Koo Han

Keyword(s):

Hepatocellular Carcinoma ◽

Targeted Therapy ◽

Treatment Group ◽

Rat Model ◽

Therapeutic Response ◽

Response Monitoring ◽

Control Group ◽

Rat Models ◽

Significant Change ◽

Operator Reproducibility

Purpose To assess therapeutic response monitoring after targeted therapy in an orthotopic rat model of hepatocellular carcinoma (HCC) using CEUS with focusing on inter-scanner and inter-operator reproducibility. Materials and methods For reproducibility, CEUS was performed using two different US scanners by two operators in sixteen rat models of HCC. Using perfusion analysis software (VueBox ®), eleven parameters were collected, and intra-class correlation coefficient (ICC) was used to analyze reproducibility. Then seventeen rat models of HCC were divided into treatment group (n = 8, 30 mg/kg/day sorafenib for five days) and control group (n = 9). CEUS was performed at baseline and 14 days after first treatment, and changes of perfusion parameters were analyzed. Results In treatment group, CEUS perfusion parameters showed a significant change. The peak enhancement (PE, 2.50 x103±1.68 x103 vs 5.55x102±4.65x102, p = 0.010) and wash-in and wash out AUC (WiWoAUC, 1.07x105±6.48 x104 vs 2.65x104±2.25x104, p = 0.009) had significantly decreased two weeks after treatment. On the contrary, control group did not show a significant change, including PE (1.15 x103±7.53x102 vs 9.43x102± 7.81 x102, p = 0.632) and WiWoAUC (5.09 x104±3.25x104 vs 5.92 x104±3.20x104, p = 0.646). For reproducibility, the various degrees of inter-scanner reproducibility were from poor to good (ICC: <0.01–0.63). However, inter-operator reproducibility of important perfusion parameters, including WiAUC, WoAUC, and WiWoAUC, ranged from fair to excellent (ICC: 0.59–0.93) in a different scanner. Conclusion Our results suggest that CEUS is useful for assessment of the treatment response after targeted therapy and with fair to excellent inter-operator reproducibility.

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