Drug-Dietary Interactions: Over-the-Counter Medications, Herbs, and Dietary Supplements

This study proposes to explore the valued aspects for persons who buy dietary supplemnets and whether pharmacists recommendation influence the buying decision and in what measure. The study is based on a initial qualitative research, followed by a quantitative research, both on pharmacists and consumers from the city of Iasi. The results differ to an extent from the findings in West European studies. Pharmacists recommendation is of subjective nature, influenced by the relation they have with the over-the-counter (OTC) producing company representative and by the trust they place in a brand or anither. From the viw of the customers, pharmacists recommendation has certain power in taking the decision to buy but it is not the most important aspect nor the only one taken into consideration. The reasearch identifies 6 important aspects for the customers when they buy OTC products and 4 aspects that the pahramacists take into account when recommending a producer od dietary supplements to the pacients.

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Effect of Group Instructions for Improving Awareness about Medication-notebook Use on the Purchase of Over-the-counter Drugs and Dietary Supplements

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) ◽

10.5649/jjphcs.41.113 ◽

2015 ◽

Vol 41 (2) ◽

pp. 113-120 ◽

Cited By ~ 5

Author(s):

Tomoya Tachi ◽

Shoko Asano ◽

Chitoshi Goto ◽

Tatsuhiko Yoshida ◽

Kazumasa Usui ◽

...

Keyword(s):

Dietary Supplements ◽

Over The Counter

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Knowledge, Perceptions, and Patterns of Fish Oil Use in Cardiac Patients

Journal of Pharmacy Practice ◽

10.1177/0897190018824485 ◽

2019 ◽

Vol 33 (5) ◽

pp. 580-585 ◽

Cited By ~ 1

Author(s):

Daniel E. Hilleman ◽

Robyn Teply ◽

Kathleen A. Packard

Keyword(s):

Fatty Acids ◽

Fish Oil ◽

Dietary Supplements ◽

Disease Patient ◽

The United States ◽

Cardiac Patients ◽

Product Knowledge ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Over The Counter

Background: Fish oils are the most widely used nonvitamin, nonmineral dietary supplements in the United States. They are not over-the-counter medications and are neither approved nor indicated for treating disease. Patient knowledge and patterns of fish oil use are not well defined. Objective: To determine cardiac patients’ knowledge and patterns of fish oil use. Methods: One thousand consecutive patients admitted to an in-patient cardiology service (2015-2017) taking fish oil dietary supplements or prescription omega-3 fatty acids were asked to complete an anonymous questionnaire concerning product knowledge and use. Results: A total of 711 (71%) patients completed the questionnaire. Primary reasons for use included general health (34%), heart health (28%), arthritis (9%), and lipid disorders (8%). Few patients (14%) were advised to take fish oil products by a health-care provider. Only 2.5% were taking prescription omega-3 fatty acids. Only 26% knew the active ingredient in their fish oil product. Supplements were purchased through a nonpharmacy retail seller by 81% of respondents. Conclusions: Most cardiac patients consuming fish oil dietary supplements do so without medical supervision and without knowledge of the active ingredients. As most patients obtain supplements outside of a pharmacy, opportunities to monitor and educate patients remain a major challenge.

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A Case of Supplement-Induced Hepatotoxicity

Case Reports in Medicine ◽

10.1155/2010/262706 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Fong-Kuei Frank Cheng ◽

Peter Dunaway

Keyword(s):

Abdominal Pain ◽

Liver Disease ◽

Liver Injury ◽

Dietary Supplements ◽

Medication Use ◽

Over The Counter ◽

Caucasian Male ◽

History Of ◽

One Year ◽

Specific Agent

A 45-year-old Caucasian male presented with a two-week history of jaundice and right-upper quadrant (RUQ) abdominal pain. Transaminases and biliary enzymes were markedly elevated with hyperferritinemia and mildly elevated INR. Imaging tests showed no significant abnormality. He denied prescription or over-the-counter (OTC) medication use, but he had been taking at least 9 dietary supplements for 12 months. Other causes of liver disease were excluded. His supplements were discontinued, and his liver-associated enzymes significantly markedly improved over the next 6 weeks and remained normal after one year suggesting supplement-induced hepatotoxicity. Due to the number of supplements, no specific agent could be identified as the primary cause of his liver injury. This case illustrates the importance of inquiring and educating patients of the potential harmful risks of over-the-counter medications and supplements.

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Use of over the counter oral relief aids or dietary supplements for the ring-opening polymerization of lactide

Dalton Transactions ◽

10.1039/c2dt31559a ◽

2013 ◽

Vol 42 (25) ◽

pp. 9274-9278 ◽

Cited By ~ 11

Author(s):

Vagulejan Balasanthiran ◽

Tamara L. Beilke ◽

Malcolm H. Chisholm

Keyword(s):

Dietary Supplements ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Over The Counter

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Determination of Coenzyme Q10 in Over-the-Counter Dietary Supplements by High-Performance Liquid Chromatography with Coulometric Detection

Journal of AOAC International ◽

10.1093/jaoac/89.1.35 ◽

2006 ◽

Vol 89 (1) ◽

pp. 35-39 ◽

Cited By ~ 5

Author(s):

Peter H Tang

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Dietary Supplements ◽

Coenzyme Q10 ◽

High Performance ◽

Limit Of Detection ◽

Detector Response ◽

Over The Counter ◽

Coulometric Detection

Abstract A rapid and sensitive method is described for the determination of coenzyme Q10 (Q10) in over-the-counter dietary supplements by automated high-performance liquid chromatography (HPLC) with coulometric detection. Sample solutions of powder-filled capsules, oil-based softgels, and tablets were prepared by serial dilution with 1-propanol. After dilution, a known volume of sample solution containing Q10 and the internal standard, coenzyme Q9 (Q9), was directly injected into the HPLC system. Most of electrochemically active compounds in the injection were oxidized at the precolumn conditioning cell and postcolumn guard cell. Q9 and Q10 were monitored at an analytical cell that contained 2 coulometric electrodes, where Q9 and Q10 were reduced to the corresponding ubiquinol-9 and -10 and then oxidized to produce currents. This method produced a linear detector response for peak height measurements over the concentration range of 0.058 g/mL (r > 0.999). The lower limit of detection was 5 ng/mL (signal-to-noise ratio, 3). The mean recovery was 98.9 0.6%; coefficients of variation for intra- and interday precisions were 1.84.0%. The proposed method was successfully applied to the determination of Q10 in marketed products.

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