Hemolytic Disease of the Fetus and Newborn/Selection of Red Cells for Intrauterine Transfusion

2018 ◽  
pp. 207-216
Author(s):  
Brian Gorospe ◽  
Nabiha Huq Saifee
Keyword(s):  
Red Cells ◽  
Hemolytic Disease ◽  
Intrauterine Transfusion ◽  
Selection Of

HEMOLYTIC DISEASE OF THE NEWBORN DUE TO ANTI-A AND ANTI-B

PEDIATRICS ◽  
1955 ◽  
Vol 15 (1) ◽  
pp. 54-62
Author(s):  
Clare N. Shumway ◽  
Gerald Miller ◽  
Lawrence E. Young
Keyword(s):  
B Cells ◽  
Red Blood Cells ◽  
Blood Group ◽  
Newborn Infant ◽  
Blood Cells ◽  
Osmotic Fragility ◽  
Red Cells ◽  
Hemolytic Disease ◽  
Abo Incompatibility

Ten infants with hemolytic disease of the newborn due to ABO incompatibility were studied. In every case the investigations were undertaken because of jaundice occurring in the first 24 hours of life. The clinical, hematologic and serologic observations in the infants and the serologic findings in the maternal sera are described. Evidence is presented to show that the diagnosis of the disorder rests largely upon the demonstration of spherocytosis, increased osmotic fragility of the red cells, reticulocytosis, and hyperbilirubinemia in a newborn infant whose red blood cells are incompatible with the maternal major blood group isoantibody and against whose cells no other maternal isoantibody is demonstrable. The anti-A or anti-B in each of the maternal sera tested in this series hemolyzed A or B cells in the presence of complement. Other serologic findings in the maternal sera were less consistently demonstrated.

scholarly journals Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study

2012 ◽  
Vol 206 (2) ◽  
pp. 141.e1-141.e8 ◽  
Author(s):  
Irene T. Lindenburg ◽  
Vivianne E. Smits-Wintjens ◽  
Jeanine M. van Klink ◽  
Esther Verduin ◽  
Inge L. van Kamp ◽  
...  
Keyword(s):  
Neurodevelopmental Outcome ◽  
Hemolytic Disease ◽  
Intrauterine Transfusion

scholarly journals Hemolytic Disease of the Newborn Due to Anti-A

Blood ◽  
1953 ◽  
Vol 8 (7) ◽  
pp. 620-639 ◽  
Author(s):  
HAL CRAWFORD ◽  
MARIE CUTBUSH ◽  
P. L. MOLLISON
Keyword(s):  
Blood Group ◽  
Osmotic Fragility ◽  
Red Cells ◽  
Coombs Test ◽  
Hemolytic Disease ◽  
A Cells

Abstract Eleven cases of hemolytic disease of the newborn are described in which the only blood group antibody in the mother's serum, incompatible with the infant's cells, was anti-A. The direct antiglobulin (Coombs) test on the infant's red cells was weakly positive in 7 cases and negative in 4 cases. In every case the mother's serum displayed immune characteristics, in particular the ability to lyse A cells. Osmotic fragility was increased in 10 out of 11 cases. This finding is contrasted with those in a series of cases of hemolytic disease of the newborn due to anti-Rh.

scholarly journals The Significance of Imunohematology Research in Relation to Menagement of Hemolitical Diseases of the Newborn in Republic of Macedonia

2014 ◽  
Vol 2 (3) ◽  
pp. 456-560 ◽  
Author(s):  
Emilija Velkova
Keyword(s):  
Pregnant Women ◽  
Clinical Significance ◽  
Morbidity And Mortality ◽  
Moderate Degree ◽  
Hemolytic Disease ◽  
Successful Management ◽  
Republic Of Macedonia ◽  
Intrauterine Transfusion ◽  
Screening And Identification

AIM: Prompt discovery of allosensibilisation to RBC’s antigens during pregnancy and successful management of HDFN in Republic of Macedonia, in order to decrease morbidity and mortality of the fetus and the newborn.MATERIALS AND METHODS: The study comprises in total 23,800 patients, 14,858 pregnant women and 8,842 newborn babies.RESULTS: The screening and identification of anti RBC’s antibodies detected in total 216 alloantibodies, out of which 81% (175) had a clinical significance. Out of the above mentioned 164 alloantibodies (65.9%) belong to the Rh system. The most often reason for a severe hemolytic disease is the anti-D antibody. The HDFN symptoms of mild and moderate degree demonstrated 32.5%, and 18.9% had symptoms of severe fetal suffering, and almost half of them (48%) were with or with mild HDFN and had no need of therapy. In 15% it was about alloantibodies of other Rg antigens: anti-C, anti-E and anti-c, at which in most cases there were no signs of HDFN, or it showed weak symptoms (89%), just one case of anti-c ended with intrauterine death.CONCLUSIONS: Anti D antibody represents the most often reason for severe HDFN and displays a need of intrauterine transfusion and exsangvino transfusion. Anti-c is the only antibody that demonstrated the same potential for severe HBN as the anti-D. The most often reason for alloimmunisation of the mother is the lack of RhIG prophylaxis (97.8): postnatal, antenatal and in case of possible sensible conditions during pregnancy. Thus, there is a need and an outmost importance of elaboration and adoption of the National programe for RhIG prophylaxis in Republic of Macedonia.

scholarly journals The Outcome of Hemolytic Disease of the Fetus and Newborn Caused by Anti-Rh17 Antibody: Analysis of Three Cases and Review of the Literature

2019 ◽  
Vol 47 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Slavica Dajak ◽  
Nina Ipavec ◽  
Mia Cuk ◽  
Branka Golubic Cepulic ◽  
Jela Mratinovic-Mikulandra ◽  
...  
Keyword(s):  
High Frequency ◽  
Exchange Transfusion ◽  
Perinatal Death ◽  
Good Health ◽  
Published Data ◽  
Review Of The Literature ◽  
Hemolytic Disease ◽  
Tertiary Institution ◽  
Intrauterine Transfusion ◽  
Different Populations

Background: Anti-Rh17 is a rare red blood cell (RBC) antibody to high-frequency antigens that may cause severe hemolytic disease of the fetus and newborn (HDFN). Despite the rarity of HDFN caused by Anti-Rh17, this antibody was reported in many different populations. Emergency transfusions, especially exchange transfusions, present a huge problem if no compatible RBCs of phenotype D-- are available. Methods: Here we report obstetrical histories of three women and describe their pregnancies complicated by anti-Rh17 antibodies. We summarized published cases of pregnancies complicated by anti-Rh17 and reviewed transfusion treatment and outcomes. Additionally, a simplified flowchart for the management of such pregnancies is proposed. Results: Four pregnancies were affected by severe HDFN, and three of them ended with perinatal death. In the fourth case, the baby was born hydropic and icteric and the condition was rapidly deteriorating. Emergency exchange transfusion was performed with incompatible O-negative RBC units in AB-negative plasma. The baby was discharged on the 14th day in good health. In the available literature, 15 women and 22 pregnancies were reported, 20 of them developed severe HDFN. According to the data, intrauterine transfusion for treatment of HDFN was the most common form of treatment with the donation of the mother’s blood. Different options for exchange transfusion were described, including incompatible RBCs. Conclusion: In more than 90% of described pregnancies of HDFN caused by anti-Rh17 antibody, transfusion treatment was required. Therefore, RBC from D-- phenotype has to be available. According to published data, in emergent circumstances when maternal and blood from donor with phenotype D-- is not available, incompatible exchange transfusion is a better choice than delaying transfusion when it is necessary. It is of essential importance that pregnancies with high risk of HDFN due to anti-Rh17 are managed by a multidisciplinary team (transfusion medicine specialist, obstetrician, neonatologist) in a highly specialized tertiary institution.

Long-term neurodevelopmental outcome after intrauterine transfusion for the treatment of fetal hemolytic disease

1998 ◽  
Vol 179 (4) ◽  
pp. 858-863 ◽  
Author(s):  
Lynda Hudon ◽  
Kenneth J. Moise ◽  
Suzanne E. Hegemier ◽  
Reba M. Hill ◽  
Alicia A. Moise ◽  
...  
Keyword(s):  
Neurodevelopmental Outcome ◽  
Hemolytic Disease ◽  
Intrauterine Transfusion

Letter to the Editor

PEDIATRICS ◽  
1972 ◽  
Vol 50 (1) ◽  
pp. 169-169
Author(s):  
Jane Desforges
Keyword(s):  
Red Cells ◽  
Hemolytic Disease ◽  
Left Behind ◽  
Abo Incompatibility ◽  
Letter To The Editor ◽  
Rh Incompatibility

In hemolytic disease, it is always difficult to comment on the properties of red cells which have already been removed from the circulation. One can only study those left behind and presumably, therefore, less injured. However, with the mechanism of immunohemolysis in Rh incompatibility as a prototype, one can propose hemolytic disease of the newborn in ABO incompatibility to be related to a coating antibody which is not complement dependent, rather than to the hemolysin.

ABO Hemolytic Disease, Complement, and Phagocytosis

PEDIATRICS ◽  
1972 ◽  
Vol 50 (1) ◽  
pp. 169-169
Author(s):  
B. D. Gordon
Keyword(s):  
Blood Transfusion ◽  
Annual Meeting ◽  
Red Cells ◽  
Red Cross ◽  
Hemolytic Disease ◽  
Australian Society ◽  
Blood Transfusion Service ◽  
Abo Hemolytic Disease ◽  
Set Up ◽  
Chemotactic Effect

The article by Drs. Wang and Desforges indicated that complement was not involved in ABO hemolytic disease because they could not detect it on red cells in such cases. In 1964, Dr. Gordon Archer of the Red Cross Blood Transfusion Service, Sydney, reported to the Second Annual Meeting of the Australian Society of Immunologists that red cells coated with anti-A or anti-B antibodies set up a strong chemotactic effect on polymorpho-nuclear leukocytes, predominantly neutrophils and eosinophils.

Sign in / Sign up

Export Citation Format

Share Document