Energetic Metabolism

2021 ◽  
pp. 350-350
Keyword(s):  
Energetic Metabolism

SOME ASPECTS OF MECHANISM OF SUCCINAMIDES INFLUENCE ON METABOLIC HOMEOSTASIS OF THE ORGANISM

2018 ◽  
pp. 27-31
Author(s):  
I. A. Palagina
Keyword(s):  
Nitric Oxide ◽  
Biological Activity ◽  
Antioxidant System ◽  
No Synthase ◽  
Antioxidant Potential ◽  
Metabolic Homeostasis ◽  
Energetic Metabolism ◽  
Complex Action ◽  
Energy Processes ◽  
Stimulation Of

Succinate containing compounds possess many types of biological activity and are used for the development of drugs with the target and complex action. This paper is devoted to some aspects of the mechanism of succinamides’ action in a dose of 100 mg/kg. We studied the influence of the compound with antidiabetic properties, -phenylethylamide of 2-oxysuccinanyl acid ( -PhEA-OSAA), and its metabolites such as 2-hydroxyphenylsuccinamide (2-HPhSA) and β-phenylethylsuccinamide ( -PhESA) on the marker indicators of energetic metabolism (EM), antioxidant system (AOS) and nitric oxide (NO) metabolism in subacute experiment on rats. Studies have shown that the action of -FEA-OSAKA on metabolic homeostasis is realized through stimulation of EM, reduction of intensity of NO-synthase metabolism and weakening of the AOS. The nature of the action of -FES and 2-GFS, taking into account the indicators of the state of homeostasis, largely coincides with β-FEA-OSAKA. It was found that the key links in the mechanism of toxic action of succinamides are the effect on antioxidant potential, NO metabolism and energy processes.

scholarly journals Probing the Energetic Metabolism of Resting Cysts under Different Conditions from Molecular and Physiological Perspectives in the Harmful Algal Blooms-Forming Dinoflagellate Scrippsiella trochoidea

2021 ◽  
Vol 22 (14) ◽  
pp. 7325
Author(s):  
Fengting Li ◽  
Aoao Yang ◽  
Zhangxi Hu ◽  
Siheng Lin ◽  
Yunyan Deng ◽  
...  
Keyword(s):  
Low Temperature ◽  
Harmful Algal Blooms ◽  
Algal Blooms ◽  
Atp Content ◽  
Energetic Metabolism ◽  
Scrippsiella Trochoidea ◽  
Vegetative Cells ◽  
F1 Atpase ◽  
Atpase Gene ◽  
Resting Cysts

Energetic metabolism is essential in maintaining the viability of all organisms. Resting cysts play important roles in the ecology of dinoflagellates, particularly for harmful algal blooms (HABs)-causative species. However, the energetic metabolism underlying the germination potency maintenance of resting cysts of dinoflagellate have been extremely scarce in studies from physiological and, particularly, molecular perspectives. Therefore, we used the cosmopolitan Scrippsiella trochoidea as a representative of HABs-forming and cyst-producing dinoflagellates in this work to obtain novel insights into the molecular mechanisms, regulating the energetic metabolism in dinoflagellate resting cysts, under different physical condition. As the starting step, we established a cDNA subtractive library via suppression subtractive hybridization (SSH) technology, from which we screened an incomplete sequence for the β subunit of ATP synthase gene (β-F1-ATPase), a key indicator for the status of cell’s energetic metabolism. The full-length cDNA of β-F1-ATPase gene from S.trochoidea (Stβ-F1-ATPase) was then obtained via rapid amplification of cDNA ends (RACE) (Accession: MZ343333). Our real-time qPCR detections, in vegetative cells and resting cysts treated with different physical conditions, revealed that (1) the expression of Stβ-F1-ATPase in resting cysts was generally much lower than that in vegetative cells, and (2) the Stβ-F1-ATPase expressions in the resting cysts under darkness, lowered temperature, and anoxia, and during an extended duration of dormancy, were significantly lower than that in cysts under the condition normally used for culture-maintaining (a 12 h light:12 h dark cycle, 21 °C, aerobic, and newly harvested). Our detections of the viability (via Neutral Red staining) and cellular ATP content of resting cysts, at the conditions corresponding to the abovementioned treatments, showed that both the viability and ATP content decreased rapidly within 12 h and then maintained at low levels within the 4-day experimentation under all the three conditions applied (4 °C, darkness, and anoxia), which are well in accordance with the measurements of the transcription of Stβ-F1-ATPase. These results demonstrated that the energy consumption of resting cysts reaches a low, but somehow stable, level within a short time period and is lower at low temperature, darkness, and anoxia than that at ambient temperature. Our work provides an important basis for explaining that resting cysts survive long-term darkness and low temperature in marine sediments from molecular and physiological levels.

scholarly journals Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies

2020 ◽  
Vol 10 (01) ◽  
pp. e104-e109
Author(s):  
Antonio Molina-Carballo ◽  
Antonio Emilio Jerez-Calero ◽  
Antonio Muñoz-Hoyos
Keyword(s):  
Endothelial Cell ◽  
Free Radical ◽  
Chronic Administration ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Energetic Metabolism ◽  
Beneficial Effects ◽  
Molecular Crosstalk

AbstractMelatonin, produced in every cell that possesses mitochondria, acts as an endogenous free radical scavenger, and improves energetic metabolism and immune function, by complex molecular crosstalk with other intracellular compounds. There is greatly increasing evidence regarding beneficial effects of acute and chronic administration of high melatonin doses, in infectious, developmental, and degenerative pathologies, as an endothelial cell and every cell protectant.

Impact of heat and cold events on the energetic metabolism of the C3 halophyte Halimione portulacoides

2015 ◽  
Vol 167 ◽  
pp. 166-177 ◽  
Author(s):  
B. Duarte ◽  
D. Santos ◽  
J.C. Marques ◽  
I. Caçador
Keyword(s):  
Energetic Metabolism ◽  
Halimione Portulacoides ◽  
Cold Events

Erythropoietin reverts cognitive impairment and alters the oxidative parameters and energetic metabolism in sepsis animal model

2012 ◽  
Vol 119 (11) ◽  
pp. 1267-1274 ◽  
Author(s):  
Clarissa M. Comim ◽  
Omar J. Cassol ◽  
Igor Abreu ◽  
Thais Moraz ◽  
Larissa S. Constantino ◽  
...  
Keyword(s):  
Animal Model ◽  
Cognitive Impairment ◽  
Energetic Metabolism

Effect of calcium intake on the interrelationship between bone turnover and energetic metabolism in genetically predisposed obese rats

Bone ◽  
2016 ◽  
Vol 89 ◽  
pp. 69
Author(s):  
C. Marotte ◽  
A. Weisstaub ◽  
J. Somoza ◽  
M.L. Pita Martin de Portela ◽  
S.N. Zeni
Keyword(s):  
Bone Turnover ◽  
Calcium Intake ◽  
Energetic Metabolism ◽  
Obese Rats

PHYSIOLOGICAL ROLE OF CIRCADIAN CLOCK GENE ON THE ENERGETIC METABOLISM IN HORSES

2021 ◽  
Author(s):  
C. Giannetto ◽  
F. Fazio ◽  
E. Giudice ◽  
G. Mazzullo ◽  
G. Piccione
Keyword(s):  
Circadian Clock ◽  
Clock Gene ◽  
Physiological Role ◽  
Energetic Metabolism ◽  
Circadian Clock Gene
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