Erythropoietin reverts cognitive impairment and alters the oxidative parameters and energetic metabolism in sepsis animal model

2012 ◽  
Vol 119 (11) ◽  
pp. 1267-1274 ◽  
Author(s):  
Clarissa M. Comim ◽  
Omar J. Cassol ◽  
Igor Abreu ◽  
Thais Moraz ◽  
Larissa S. Constantino ◽  
...  
Keyword(s):  
Animal Model ◽  
Cognitive Impairment ◽  
Energetic Metabolism

scholarly journals Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

2020 ◽  
Vol 21 (6) ◽  
pp. 2176 ◽  
Author(s):  
Amelia Nur Vidyanti ◽  
Jia-Yu Hsieh ◽  
Kun-Ju Lin ◽  
Yao-Ching Fang ◽  
Ismail Setyopranoto ◽  
...  
Keyword(s):  
Animal Model ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Chronic Phase ◽  
Vascular Cognitive Impairment ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Hippocampal Atrophy ◽  
Tnf Α

The pathophysiology of vascular cognitive impairment (VCI) is associated with chronic cerebral hypoperfusion (CCH). Increased high-mobility group box protein 1 (HMGB1), a nonhistone protein involved in injury and inflammation, has been established in the acute phase of CCH. However, the role of HMGB1 in the chronic phase of CCH remains unclear. We developed a novel animal model of CCH with a modified bilateral common carotid artery occlusion (BCCAO) in C57BL/6 mice. Cerebral blood flow (CBF) reduction, the expression of HMGB1 and its proinflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-1β, and IL-6), and brain pathology were assessed. Furthermore, we evaluated the effect of HMGB1 suppression through bilateral intrahippocampus injection with the CRISPR/Cas9 knockout plasmid. Three months after CCH induction, CBF decreased to 30–50% with significant cognitive decline in BCCAO mice. The 7T-aMRI showed hippocampal atrophy, but amyloid positron imaging tomography showed nonsignificant amyloid-beta accumulation. Increased levels of HMGB1, TNF-α, IL-1β, and IL-6 were observed 3 months after BCCAO. HMGB1 suppression with CRISPR/Cas9 knockout plasmid restored TNF-α, IL-1β, and IL-6 and attenuated hippocampal atrophy and cognitive decline. We believe that HMGB1 plays a pivotal role in CCH-induced VCI pathophysiology and can be a potential therapeutic target of VCI.

Environmental enrichment protects against cognitive impairment following chemotherapy in an animal model.

2016 ◽  
Vol 130 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Gordon Winocur ◽  
J. Martin Wojtowicz ◽  
Christina M. Merkley ◽  
Ian F. Tannock
Keyword(s):  
Animal Model ◽  
Cognitive Impairment ◽  
Environmental Enrichment

Alterations of transduction mechanisms in an animal model of cognitive impairment

1990 ◽  
Vol 22 ◽  
pp. 113
Author(s):  
M. Cimino ◽  
M. Di Luca ◽  
W. Balduini ◽  
G. Lombardelli ◽  
G. Peruzzi ◽  
...  
Keyword(s):  
Animal Model ◽  
Cognitive Impairment ◽  
Transduction Mechanisms

The Role of Secretase Pathway in Long-term Brain Inflammation and Cognitive Impairment in an Animal Model of Severe Sepsis

2019 ◽  
Vol 57 (2) ◽  
pp. 1159-1169 ◽  
Author(s):  
Cleonice Michelon ◽  
Monique Michels ◽  
Mariane Abatti ◽  
Andriele Vieira ◽  
Heloisa Borges ◽  
...  
Keyword(s):  
Animal Model ◽  
Severe Sepsis ◽  
Cognitive Impairment ◽  
Brain Inflammation

scholarly journals Mangifera indicaFruit Extract Improves Memory Impairment, Cholinergic Dysfunction, and Oxidative Stress Damage in Animal Model of Mild Cognitive Impairment

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Wipawee Thukham-Mee ◽  
Kornkanok Ingkaninan ◽  
Sakchai Wittaya-Areekul
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Impairment ◽  
Cholinergic Neurons ◽  
Protective Agent ◽  
Cholinergic Dysfunction ◽  
Stress Damage ◽  
And Oxidative Stress

To date, the effective preventive paradigm against mild cognitive impairment (MCI) is required. Therefore, we aimed to determine whetherMangifera indicafruit extract, a substance possessing antioxidant and cognitive enhancing effects, could improve memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment. Male Wistar rats, weighing 180–200 g, were orally given the extract at doses of 12.5, 50, and 200 mg·kg−1BW for 2 weeks before and 1 week after the bilateral injection of AF64A (icv). At the end of study, spatial memory, cholinergic neurons density, MDA level, and the activities of SOD, CAT, and GSH-Px enzymes in hippocampus were determined. The results showed that all doses of extract could improve memory together with the decreased MDA level and the increased SOD and GSH-Px enzymes activities. The increased cholinergic neurons density in CA1 and CA3 of hippocampus was also observed in rats treated with the extract at doses of 50 and 200 mg·kg−1BW. Therefore, our results suggested thatM. indica, the potential protective agent against MCI, increased cholinergic function and the decreased oxidative stress which in turn enhanced memory. However, further researches are essential to elucidate the possible active ingredients and detail mechanism.

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