Pulmonary Matrikines: Origin, Function, and Contribution to Fibrotic and Non-fibrotic Lung Disease

2018 ◽  
pp. 121-133
Author(s):  
Gautam George ◽  
Janice Walker ◽  
Ross Summer
Keyword(s):  
Lung Disease ◽  
Origin Function ◽  
Fibrotic Lung Disease

scholarly journals Complications in Idiopathic Pulmonary Fibrosis: Focus on Their Clinical and Radiological Features

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 450
Author(s):  
Federica Galioto ◽  
Stefano Palmucci ◽  
Giovanna M. Astuti ◽  
Ada Vancheri ◽  
Giulio Distefano ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Integrated Approach ◽  
Correct Treatment ◽  
Radiological Features ◽  
Palliative Care Services ◽  
Pictorial Essay ◽  
Personalized Approach ◽  
Fibrotic Lung Disease

Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with uncertain origins and pathogenesis; it represents the most common interstitial lung disease (ILD), associated with a pathological pattern of usual interstitial pneumonitis (UIP). This disease has a poor prognosis, having the most lethal prognosis among ILDs. In fact, the progressive fibrosis related to IPF could lead to the development of complications, such as acute exacerbation, lung cancer, infections, pneumothorax and pulmonary hypertension. Pneumologists, radiologists and pathologists play a key role in the identification of IPF disease, and in the characterization of its complications—which unfortunately increase disease mortality and reduce overall survival. The early identification of these complications is very important, and requires an integrated approach among specialists, in order to plane the correct treatment. In some cases, the degree of severity of patients having IPF complications may require a personalized approach, based on palliative care services. Therefore, in this paper, we have focused on clinical and radiological features of the complications that occurred in our IPF patients, providing a comprehensive and accurate pictorial essay for clinicians, radiologists and surgeons involved in their management.

scholarly journals Collaborative Radiologic and Histopathologic Assessment of Fibrotic Lung Disease

Radiology ◽  
2010 ◽  
Vol 255 (3) ◽  
pp. 692-706 ◽  
Author(s):  
Jeffrey R. Galvin ◽  
Aletta Ann Frazier ◽  
Teri J. Franks
Keyword(s):  
Lung Disease ◽  
Fibrotic Lung Disease

scholarly journals VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease

2018 ◽  
Vol 19 (5) ◽  
pp. 1269 ◽  
Author(s):  
Shaney Barratt ◽  
Victoria Flower ◽  
John Pauling ◽  
Ann Millar
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Lung Disease ◽  
Vascular Endothelial ◽  
Fibrotic Lung Disease ◽  
Endothelial Growth Factor

Low-frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease

2021 ◽  
Vol 38 (6) ◽  
pp. 594-595
Author(s):  
S. Le Guellec ◽  
L. Allimonnier ◽  
N. Heuzé-Vourc’h ◽  
M. Cabrera ◽  
F. Ossant ◽  
...  
Keyword(s):  
Lung Disease ◽  
Physical Model ◽  
Low Frequency ◽  
Fibrotic Lung Disease

scholarly journals Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

Cell Reports ◽  
2019 ◽  
Vol 27 (12) ◽  
pp. 3709-3723.e5 ◽  
Author(s):  
Alexandros Strikoudis ◽  
Anna Cieślak ◽  
Lucas Loffredo ◽  
Ya-Wen Chen ◽  
Nina Patel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Lung Disease ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Fibrotic Lung Disease

scholarly journals Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease

2020 ◽  
Vol 8 ◽  
Author(s):  
Sandrine Le Guellec ◽  
Laurine Allimonnier ◽  
Nathalie Heuzé-Vourc’h ◽  
Maria Cabrera ◽  
Frédéric Ossant ◽  
...  
Keyword(s):  
Lung Disease ◽  
Physical Model ◽  
Low Frequency ◽  
Fibrotic Lung Disease

scholarly journals The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease

2019 ◽  
Vol 6 (1) ◽  
pp. e000439 ◽  
Author(s):  
Fasihul Khan ◽  
Iain Stewart ◽  
Lucy Howard ◽  
Tricia M McKeever ◽  
Steve Jones ◽  
...  
Keyword(s):  
Cohort Study ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Molecular Mechanisms ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Ethical Approval ◽  
Observational Cohort ◽  
Fibrotic Lung Disease

IntroductionThe Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS) is a multicentre, prospective, observational cohort study. The aims of this study are to identify genetic, serum and other biomarkers that may identify specific molecular mechanisms, reflecting disease endotypes that are shared among patients with progressive pulmonary fibrosis regardless of aetiology. Furthermore, it is anticipated that these biomarkers will help predict fibrotic activity that may identify patterns of disease behaviour with greater accuracy than current clinical phenotyping.Methods and analysis200 participants with the multidisciplinary team confirmed fibrotic lung disease (50 each of rheumatoid-interstitial lung disease (ILD), asbestosis, chronic hypersensitivity pneumonitis and unclassifiable ILD) and 50 idiopathic pulmonary fibrosis participants, recruited as positive controls, will be followed up for 2 years. Participants will have blood samples, lung function tests, quality of life questionnaires and a subgroup will be offered bronchoscopy. Participants will also be given the option of undertaking blinded home handheld spirometry for the first 3 months of the study. The primary end point will be identification of a biomarker that predicts disease progression, defined as 10% relative change in forced vital capacity (FVC) or death at 12 months.Ethics and disseminationThe trial has received ethical approval from the National Research Ethics Committee Nottingham (18/EM/0139). All participants must provide written informed consent. The trial will be overseen by the INJUSTIS steering group that will include a patient representative, and an independent chairperson. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at regional and national conferences.Trial registration numberNCT03670576.

scholarly journals PRS56 - COST-EFFECTIVENESS OF AMBULATORY OXYGEN IN IMPROVING QUALITY OF LIFE IN FIBROTIC LUNG DISEASE: A TALE OF TWO OUTCOMES

2018 ◽  
Vol 21 ◽  
pp. S413-S414
Author(s):  
J. Whitty ◽  
J. Rankin ◽  
P. Sestini ◽  
L. Mori ◽  
V. Tsipouri ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cost Effectiveness ◽  
Lung Disease ◽  
Fibrotic Lung Disease
Sign in / Sign up

Export Citation Format

Share Document