Multi-Effect-Coupling Thermal-Stimulus (MECtherm) Model for Temperature-Sensitive Hydrogel

2009 ◽  
pp. 219-293
Author(s):  
Hua Li
Keyword(s):  
Temperature Sensitive ◽  
Thermal Stimulus ◽  
Temperature Sensitive Hydrogel

Interactions between temperature-sensitive hydrogel microspheres and granulocytes

1995 ◽  
Vol 6 (7) ◽  
pp. 534-540 ◽  
Author(s):  
Koji Achiha ◽  
Rika Ojima ◽  
Yuji Kasuya ◽  
Keiji Fujimoto ◽  
Haruma Kawaguchi
Keyword(s):  
Temperature Sensitive ◽  
Temperature Sensitive Hydrogel ◽  
Hydrogel Microspheres

Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure

2010 ◽  
Vol 148-149 ◽  
pp. 1427-1430 ◽  
Author(s):  
Kui Lin Deng ◽  
Li Rong Dong ◽  
Yu E Shi ◽  
Yu Bo Gou ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Phosphate Buffer Solution ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Bead ◽  
The Core ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Biomedical Fields

As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was much faster at 18 oC than that at 37 oC due to the temperature sensitivity of poly(N-acryloylglycinates). The experimental results indicate that pTSB seems to have a potential application in the drug release system controlled via pH or temperature in the biomedical fields.

A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

2010 ◽  
Vol 148-149 ◽  
pp. 1449-1452 ◽  
Author(s):  
Kui Lin Deng ◽  
Yu Bo Gou ◽  
Jian Zuo ◽  
Li Rong Dong ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Beads ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

scholarly journals Hydrogels as dynamic memory with forgetting ability

2020 ◽  
Vol 117 (32) ◽  
pp. 18962-18968 ◽  
Author(s):  
Chengtao Yu ◽  
Honglei Guo ◽  
Kunpeng Cui ◽  
Xueyu Li ◽  
Ya Nan Ye ◽  
...  
Keyword(s):  
Thermal History ◽  
Soft Matter ◽  
Future Research ◽  
Temperature Sensitive ◽  
Thermal Stimulus ◽  
Water Release ◽  
Dynamic Memory ◽  
Learning Time ◽  
Hard Materials ◽  
External Stimuli

The memory of our brain, stored in soft matter, is dynamic, and it forgets spontaneously to filter unimportant information. By contrast, the existing manmade memory, made from hard materials, is static, and it does not forget without external stimuli. Here we propose a principle for developing dynamic memory from soft hydrogels with temperature-sensitive dynamic bonds. The memorizing–forgetting behavior is achieved based on fast water uptake and slow water release upon thermal stimulus, as well as thermal-history-dependent transparency change of these gels. The forgetting time is proportional to the thermal learning time, in analogy to the behavior of brain. The memory is stable against temperature fluctuation and large stretching; moreover, the forgetting process is programmable. This principle may inspire future research on dynamic memory based on the nonequilibrium process of soft matter.

An ROS-sensitive tegafur-PpIX-heterodimer-loaded in situ injectable thermosensitive hydrogel for photodynamic therapy combined with chemotherapy to enhance the tegafur-based treatment of breast cancer

2021 ◽  
Vol 9 (1) ◽  
pp. 221-237
Author(s):  
Zhiqiang Zhang ◽  
Anning Li ◽  
Xingqi Min ◽  
Qunqun Zhang ◽  
Jun Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Protoporphyrin Ix ◽  
Temperature Sensitive ◽  
Thermosensitive Hydrogel ◽  
Temperature Sensitive Hydrogel

A temperature-sensitive hydrogel encapsulating tegafur and protoporphyrin IX dimers could be delivered intratumorally for synergetic chemotherapy and photodynamic therapy.

Nanostructure controlled sustained delivery of human growth hormone using injectable, biodegradable, pH/temperature responsive nanobiohybrid hydrogel

Nanoscale ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 3043-3054 ◽  
Author(s):  
Narendra K. Singh ◽  
Quang Vinh Nguyen ◽  
Bong Sup Kim ◽  
Doo Sung Lee
Keyword(s):  
Growth Hormone ◽  
Layered Double Hydroxide ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Temperature Sensitive ◽  
Sustained Delivery ◽  
Temperature Responsive ◽  
Hydrogel Matrix ◽  
Temperature Sensitive Hydrogel ◽  
Double Hydroxide

The combination of layered double hydroxide nanoclay particles and pH/temperature-sensitive hydrogel matrix effectively controlled the delivery of human growth hormone.

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