A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

2010 ◽  
Vol 148-149 ◽  
pp. 1449-1452 ◽  
Author(s):  
Kui Lin Deng ◽  
Yu Bo Gou ◽  
Jian Zuo ◽  
Li Rong Dong ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Beads ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure

2010 ◽  
Vol 148-149 ◽  
pp. 1427-1430 ◽  
Author(s):  
Kui Lin Deng ◽  
Li Rong Dong ◽  
Yu E Shi ◽  
Yu Bo Gou ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Phosphate Buffer Solution ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Bead ◽  
The Core ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Biomedical Fields

As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was much faster at 18 oC than that at 37 oC due to the temperature sensitivity of poly(N-acryloylglycinates). The experimental results indicate that pTSB seems to have a potential application in the drug release system controlled via pH or temperature in the biomedical fields.

Preparation and Drug Release Behavior from a Temperature-Sensitive Poly(aspartic Acid) Derivatives Hydrogel

2013 ◽  
Vol 711 ◽  
pp. 18-21
Author(s):  
Kui Lin Deng ◽  
Chun Xiu Li ◽  
Ting Gao ◽  
Xiao Dan Fu ◽  
Wen Hui Jin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aspartic Acid ◽  
Ph Value ◽  
Phosphate Buffer Solution ◽  
Temperature Sensitive ◽  
Release Behavior ◽  
Buffer Solution ◽  
Drug Release Behavior ◽  
Drug Delivery Carrier ◽  
Increasing Temperature

In this paper, a new pH/temperature-sensitive beads with semi-interpenetrating polymeric network based on sodium alginate(SA) and poly(aspartic acid) derivatives(M-E-PSI) were prepared using as drug delivery carrier. With indomethacin as a drug model，we investigated the release behaviors of indomethacin in different pH value, temperature and ratio of SA/ M-E-PSI. It turned out that the release amount of indomethacin in pH=2.1 phosphate buffer solution(PBS) was evidently higher than that in pH=7.4 PBS. And also, the release amount of indomethacin was also increased with increasing temperature and poly(aspartic acid) derivatives content in the beads.

The Study of Albumin Release from Silica/Albumin as a Potential Drug Delivery Carrier

2014 ◽  
Vol 69 (5) ◽  
Author(s):  
Shafiyah Pondi ◽  
Jon Efendi ◽  
Ho Chin Siong ◽  
Lai Sin Yuan ◽  
Sheela Chandren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fumed Silica ◽  
In Vitro Release ◽  
Phosphate Buffer Solution ◽  
Buffer Solution ◽  
Solution Ph ◽  
Drug Delivery Carrier ◽  
High Interaction ◽  
Uv Visible

The drug-delivery field has been an attractive as well as challenging area for research. With the emerging of new formulated drugs and pharmaceutical compounds, development of good drug-delivery system (DDS) is crucially required. This study aims to utilize albumin as the drug template in silica/albumin/drug (S/A/D) system. Prior to designing this system, the interaction between silica and albumin was investigated. It is hypothesized that high interaction between silica and albumin may result in slower drug release over time, which is preferred for a good DDS. Silica and albumin (S/A) materials were prepared by using fumed silica and tetraethyl orthosilicate (TEOS) as the silica precursors. Three different S/A samples were prepared; fumed silica with albumin (FS/A), fumed silica with pre-treated albumin by sodium borohydrate (FS/A-N), and silica sol (TEOS) with albumin (SS/A). In-vitro release of albumin in phosphate buffer solution (pH 7) was carried out to examine the interaction between albumin and silica. The concentration of albumin was detected at 280 nm by UV-visible spectrophotometer. All samples were characterized by diffuse reflectance-UV-visible spectrophotometer (DR-UV), Fourier transform infrared spectrophotometer (FTIR) dan thermogravimetric-differential thermal analysis (TG-DTA). DR-UV results show that SS/A exhibited the lowest absorption intensity at 280 nm, which indicates better interaction between silica and albumin. This result was supported by the presence of Si-O stretching band of silanol at 952 cm-1 from the FTIR spectrum. Release study of albumin demonstrated that the release of albumin from SS/A was slowest compared to those of FS/A and FS/A-N. 

Drug Release Characteristics of P(AA-co-DMAA)/SA Interpenetrating Polymer Network Hydrogels

2011 ◽  
Vol 399-401 ◽  
pp. 1165-1168
Author(s):  
Na Na Wang ◽  
Song Bai Lin ◽  
Ke Ping Wang ◽  
Ai Ru Ke
Keyword(s):  
Reaction Time ◽  
Release Rate ◽  
Ph Value ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Buffer Solution ◽  
Berberine Hydrochloride ◽  
Effects Of Ph ◽  
The One

P(AA-co-DMAA) superporous drug-loaded hydrogels containing berberine hydrochloride were prepared by dispersion polymerization in foam system with acrylic acid (AA) and N,N-dimethyl acrylamide (DMAA) as monomers. Then sodium alginate (SA) as the second network was added to the system, and P(AA-co-DMAA)/SA interpenetrating polymer network (IPN) hydrogels were formed. The effects of pH value, reaction time between SA and glutaric dialdehyde (GA), the concentration of SA and GA on release behavior of berberine hydrochloride were discussed. The FT-IR spectra showed that P(AA-co-DMAA)/SA IPN hydrogels were synthesized successfully. The inverted fluorescence micrograph of P(AA-co-DMAA)/SA showed that some part of the superporous structures were still retained.The cumulative release profiles showed that the release rates were slightly higher in pH=6.8 phosphate buffer solution (PBS) than the one in pH=1 HCl solution. The release rate was the slowest in distilled water, only 7.3% within 24h. When the reaction time between SA and GA was shortened, the release speed of berberine hydrochloride became faster. The pore size of P(AA-co-DMAA) hydrogels was reduced with the concentration of SA and GA increased, and the release rate decreased due to the more dense network structures.

scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

scholarly journals Carbon-Based Magnetic Nanocarrier for Controlled Drug Release: A Green Synthesis Approach

2018 ◽  
Vol 5 (1) ◽  
pp. 1 ◽  
Author(s):  
Jessica Oliveira ◽  
Raquel Rodrigues ◽  
Lillian Barros ◽  
Isabel Ferreira ◽  
Luís Marchesi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Phosphate Buffer ◽  
Colloidal Stability ◽  
Ph Dependence ◽  
Phosphate Buffer Solution ◽  
Controlled Drug Release ◽  
Buffer Solution ◽  
Carbon Based

In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer "in situ" by means of controlled drug release.

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