Dynamic Simulations of Kidney Exchanges

2011 ◽  
pp. 539-544 ◽  
Author(s):  
M. Beccuti ◽  
V. Fragnelli ◽  
G. Franceschinis ◽  
S. Villa
Keyword(s):  
Dynamic Simulations

Prediction of Tire Tread Wear with FEM Steady State Rolling Contact Simulation

2003 ◽  
Vol 31 (3) ◽  
pp. 189-202 ◽  
Author(s):  
D. Zheng
Keyword(s):  
Weight Loss ◽  
Steady State ◽  
Cross Section ◽  
Rolling Contact ◽  
Dynamic Simulations ◽  
Element Analysis ◽  
Vehicle Acceleration ◽  
Steady State Rolling ◽  
Driving Conditions ◽  
Rate Profile

Abstract A procedure based on steady state rolling contact Finite Element Analysis (FEM) has been developed to predict tire cross section tread wear profile under specified vehicle driving conditions. This procedure not only considers the tire construction effects, it also includes the effects of materials, vehicle setup, test course, and driver's driving style. In this algorithm, the vehicle driving conditions are represented by the vehicle acceleration histogram. Vehicle dynamic simulations are done to transform the acceleration histogram into tire loading condition distributions for each tire position. Tire weight loss rates for different vehicle accelerations are generated based on a steady state rolling contact simulation algorithm. Combining the weight loss rate and the vehicle acceleration histogram, nine typical tire loading conditions are chosen with different weight factors to represent tire usage conditions. It is discovered that the tire tread wear rate profile is changing continuously as the tire is worn. Simulation of a new tire alone cannot be used to predict the tire cross-section tread wear profile. For this reason, an incremental tread wear simulation procedure is performed to predict the tire cross section tread wear profile. Compared with actual tire cross-section tread wear profiles, good results are obtained from the simulations.

Spotting Differences in Molecular Dynamic Simulations of Influenza A M2 Protein-Ligand Complexes by Varying M2 construct, Lipid Bilayer and Force Field

2019 ◽  
Author(s):  
Dimitrios Kolokouris ◽  
Iris Kalenderoglou ◽  
Panagiotis Lagarias ◽  
Antonios Kolocouris
Keyword(s):  
Molecular Dynamic ◽  
Lipid Bilayer ◽  
Influenza A ◽  
Md Simulations ◽  
Membrane Curvature ◽  
Buffer Size ◽  
M2 Protein ◽  
Dynamic Simulations ◽  
Amphipathic Helices ◽  
Drug Protein Binding

<p>We studied by molecular dynamic (MD) simulations systems including the inward<sub>closed</sub> state of influenza A M2 protein in complex with aminoadamantane drugs in membrane bilayers. We varied the M2 construct and performed MD simulations in M2TM or M2TM with amphipathic helices (M2AH). We also varied the lipid bilayer by changing either the lipid, DMPC or POPC, POPE or POPC/cholesterol (chol), or the lipids buffer size, 10x10 Å<sup>2 </sup>or 20x20 Å<sup>2</sup>. We aimed to suggest optimal system conditions for the computational description of this ion channel and related systems. Measures performed include quantities that are available experimentally and include: (a) the position of ligand, waters and chlorine anion inside the M2 pore, (b) the passage of waters from the outward Val27 gate of M2 S31N in complex with an aminoadamantane-aryl head blocker, (c) M2 orientation, (d) the AHs conformation and structure which is affected from interactions with lipids and chol and is important for membrane curvature and virus budding. In several cases we tested OPLS2005, which is routinely applied to describe drug-protein binding, and CHARMM36 which describes reliably protein conformation. We found that for the description of the ligands position inside the M2 pore, a 10x10 Å<sup>2</sup> lipids buffer in DMPC is needed when M2TM is used but 20x20 Å<sup>2</sup> lipids buffer of the softer POPC; when M2AH is used all 10x10 Å<sup>2</sup> lipid buffers with any of the tested lipids can be used. For the passage of waters at least M2AH with a 10x10 Å<sup>2</sup> lipid buffer is needed. The folding conformation of AHs which is defined from hydrogen bonding interactions with the bilayer and the complex with chol is described well with a 10x10 Å<sup>2</sup> lipids buffer and CHARMM36. </p>

THE APPROACHES TO THE SOLVING ENVIRONMENTAL AND ECONOMIC PROBLEMS OF SUSTAINABLE DEVELOPMENT ON THE SHELF OF THE ARCTIC SEAS OF THE RUSSIAN FEDERATION

2017 ◽  
Author(s):  
Alexander Krivichev ◽  
Alexander Krivichev
Keyword(s):  
Continental Shelf ◽  
Oil Spill ◽  
The Arctic ◽  
Marginal Stability ◽  
Environmental Benefit ◽  
Arctic Seas ◽  
Dynamic Simulations ◽  
Economic Problems ◽  
Technogenic Loads ◽  
Oil Spill Response

Russian Arctic shelf - rich larder of the hydrocarbons, at the same time Northern Sea Route (NSR) - a strategically important route for transporting them. The extraction and the transportation of the hydrocarbons along the NSR requires the solution of a number of ecological and economic problems in the first place to ensure environmental and technogenic safety. For the solving of these problems on the continental shelf it is required a system of comprehensive measures: - the development of the regulatory framework for environmental support oil and gas projects; - the introduction and use of integrated methods for monitoring environmental conditions at the sites of technogenic loads on the shelf of the Arctic seas, including the use of drones; - creating different models for assessing the marginal stability of ecosystems to technogenic loads during production and transportation of hydrocarbons on the continental shelf based on systems of dynamic simulations; - the development and use of sensitivity maps of coastal areas of the Arctic seas during oil spill response; - accounting of the results of the analysis of the total environmental benefit in the development of oil spill response plans; - application of the principle of "zero" resetting, due to the high fishery valuation in Barents and Kara seas and the conservation of marine biological resources.

Simulation of the Impact of Higher Ammonia Recycle Loads Caused by Upgrading Anaerobic Sludge Digesters

2005 ◽  
Vol 40 (4) ◽  
pp. 491-499 ◽  
Author(s):  
Jeremy T. Kraemer ◽  
David M. Bagley
Keyword(s):  
Anaerobic Digestion ◽  
Biogas Production ◽  
Treatment Plant ◽  
Anaerobic Sludge ◽  
Content Increase ◽  
Limited Information ◽  
Dynamic Simulations ◽  
Treatment Train ◽  
Temperature Liquid ◽  
The Impact

Abstract Upgrading conventional single-stage mesophilic anaerobic digestion to an advanced digestion technology can increase sludge stability, reduce pathogen content, increase biogas production, and also increase ammonia concentrations recycled back to the liquid treatment train. Limited information is available to assess whether the higher ammonia recycle loads from an anaerobic sludge digestion upgrade would lead to higher discharge effluent ammonia concentrations. Biowin, a commercially available wastewater treatment plant simulation package, was used to predict the effects of anaerobic digestion upgrades on the liquid train performance, especially effluent ammonia concentrations. A factorial analysis indicated that the influent total Kjeldahl nitrogen (TKN) and influent alkalinity each had a 50-fold larger influence on the effluent NH3 concentration than either the ambient temperature, liquid train SRT or anaerobic digestion efficiency. Dynamic simulations indicated that the diurnal variation in effluent NH3 concentration was 9 times higher than the increase due to higher digester VSR. Higher recycle NH3 loads caused by upgrades to advanced digestion techniques can likely be adequately managed by scheduling dewatering to coincide with periods of low influent TKN load and ensuring sufficient alkalinity for nitrification.

scholarly journals Piezoresistive dynamic simulations of FDM 3D-Printed embedded strain sensors: a new modal approach

2019 ◽  
Vol 24 ◽  
pp. 390-397 ◽  
Author(s):  
Marco Maurizi ◽  
Filippo Cianetti ◽  
Janko Slavič ◽  
Guido Zucca ◽  
Massimiliano Palmieri
Keyword(s):  
Strain Sensors ◽  
Dynamic Simulations ◽  
Modal Approach ◽  
3D Printed

DESIGN AND SIMULATION OF A 1-DOF ANTHROPOMORPHIC CLUTCHED ARM FOR HUMANOID ROBOTS

2010 ◽  
Vol 07 (01) ◽  
pp. 157-182 ◽  
Author(s):  
HAO GU ◽  
MARCO CECCARELLI ◽  
GIUSEPPE CARBONE
Keyword(s):  
Humanoid Robot ◽  
Humanoid Robots ◽  
Robot Arm ◽  
Dynamic Simulations ◽  
Suitable Combination ◽  
User Friendly

In this paper, problems for an anthropomorphic robot arm are approached for an application in a humanoid robot with the specific features of cost oriented design and user-friendly operation. One DOF solution is proposed by using a suitable combination of gearing systems, clutches, and linkages. Models and dynamic simulations are used both for designing the system and checking the operation feasibility.

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