Structure and Function of the Genome of Viruses Containing Single-Stranded RNA as Genetic Material: The Concept of Transcription and Translation Helices and the Classification of these Viruses into Six Groups

1977 ◽  
pp. 239-248 ◽  
Author(s):  
Gerd Wengler
Keyword(s):  
Genetic Material ◽  
Structure And Function ◽  
And Function

scholarly journals ELIXIR pilot action: Marine metagenomics – towards a domain specific set of sustainable services

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 70 ◽  
Author(s):  
Espen Mikal Robertsen ◽  
Hubert Denise ◽  
Alex Mitchell ◽  
Robert D. Finn ◽  
Lars Ailo Bongo ◽  
...  
Keyword(s):  
Environmental Samples ◽  
Genetic Material ◽  
Structure And Function ◽  
Marine Microbes ◽  
Exploration And Exploitation ◽  
Domain Specific ◽  
User Centric ◽  
Sustainable Services ◽  
And Function ◽  
Insight Into

Metagenomics, the study of genetic material recovered directly from environmental samples, has the potential to provide insight into the structure and function of heterogeneous microbial communities.  There has been an increased use of metagenomics to discover and understand the diverse biosynthetic capacities of marine microbes, thereby allowing them to be exploited for industrial, food, and health care products. This ELIXIR pilot action was motivated by the need to establish dedicated data resources and harmonized metagenomics pipelines for the marine domain, in order to enhance the exploration and exploitation of marine genetic resources. In this paper, we summarize some of the results from the ELIXIR pilot action “Marine metagenomics – towards user centric services”.

scholarly journals IX. On the structure and development of the liver

1849 ◽  
Vol 139 ◽  
pp. 109-137 ◽  
Keyword(s):  
Royal Society ◽  
A Priori ◽  
Structural Features ◽  
Structure And Function ◽  
Conclusive Evidence ◽  
Interesting Paper ◽  
Biliary Ducts ◽  
And Function ◽  
Do So

In venturing to offer a second communication to the Royal Society respecting the structure of the liver, I feel the rather anxious to do so, that I may have an opportunity of correcting an error and supplying a deficiency which existed in my previous paper. In the following observations I purpose to present some account of the structure of the liver examined in the ascending series of animals, and also to describe the several stages of its evolution in the embryo; in this way I trust I may be able to exhibit the characteristic structural features of the organ as it exists in Man and the higher animals, and also to determine the true place which ought to be assigned to it in a classification of the various glandular organs occurring in the same. I am not aware that any detailed account of the structure of the liver has been recently published, except that by M. Natalis Guillot, which however, so far as I comprehend it, does not seem to be one that can be readily accepted; the idea that the minute biliary ducts and lymphatics originate together in a common net-work, is à priori improbable, and entirely opposed to conclusive evidence (as I think), which will be subsequently adduced. A very interesting paper on the structure and function of the liver has also appeared in the 4th volume of the Guy’s Hospital Reports, from the pen of Dr. Williams; to his labours I shall several times have occasion to refer, but it will be seen that I differ from him in several particulars, especially respecting the importance of the basement or limitary membrane.

scholarly journals Comprehensive in silico Analysis of IKBKAP gene that could potentially cause Familial dysautonomia

2018 ◽  
Author(s):  
Mujahed I. Mustafa ◽  
Enas A. Osman ◽  
Abdelrahman H. Abdelmoneiom ◽  
Dania M. Hassn ◽  
Hadeel M. Yousif ◽  
...  
Keyword(s):  
In Silico ◽  
Genetic Disorder ◽  
In Silico Analysis ◽  
Familial Dysautonomia ◽  
Structural Effect ◽  
Structure And Function ◽  
Genetic Studies ◽  
And Function ◽  
Silico Analysis

AbstractBackgroundFamilial dysautonomia (FD) is a rare neurodevelopmental genetic disorder within the larger classification of hereditary sensory and autonomic neuropathies. We aimed to identify the pathogenic SNPs in IKBKAP gene by computational analysis software’s, and to determine the structure, function and regulation of their respective proteins.Materials and MethodsWe carried out in silico analysis of structural effect of each SNP using different bioinformatics tools to predict SNPs influence on protein structure and function.Result41 novel mutations out of 973 nsSNPs that are found be deleterious effect on the IKBKAP structure and function.ConclusionThis is the first in silico analysis in IKBKAP gene to prioritize SNPs for further genetic studies.

scholarly journals Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

2021 ◽  
Vol 8 ◽  
Author(s):  
Ariana A. Vasconcelos ◽  
Jorge C. Estrada ◽  
Victor David ◽  
Luciana S. Wermelinger ◽  
Fabio C. L. Almeida ◽  
...  
Keyword(s):  
Snake Venom ◽  
Disulfide Bonds ◽  
Structure And Function ◽  
Matrix Interaction ◽  
Cell Matrix ◽  
Snake Venom Metalloproteinase ◽  
Function Relationship ◽  
And Function ◽  
Relationship Of

Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell and cell-matrix interaction that are widely studied as therapeutic targets. Snake venom disintegrins emerged from the snake venom metalloproteinase and are classified according to the sequence size and number of disulfide bonds. Evolutive structure and function diversification of disintegrin family involves a stepwise decrease in the polypeptide chain, loss of cysteine residues, and selectivity. Since the structure elucidation of echistatin, the description of the structural properties of disintegrins has allowed the investigation of the mechanisms involved in integrin-cell-extracellular matrix interaction. This review provides an analysis of the structures of all family groups enabling the description of an expanded classification of the disintegrin family in seven groups. Each group presents a particular disulfide pattern and sequence signatures, facilitating the identification of new disintegrins. The classification was based on the disintegrin-like domain of the human metalloproteinase (ADAM-10). We also present the sequence and structural signatures important for disintegrin-integrin interaction, unveiling the relationship between the structure and function of these proteins.

Kinematic Structural and Functional Analysis of Wobble-Plate Engines

1986 ◽  
Vol 108 (2) ◽  
pp. 226-236 ◽  
Author(s):  
Z. Yu ◽  
Ting W. Lee
Keyword(s):  
Functional Analysis ◽  
Design Guidelines ◽  
Structure And Function ◽  
General Nature ◽  
Mathematical Approach ◽  
Type Synthesis ◽  
Optimization Criteria ◽  
Design Heuristics ◽  
And Function

This paper concerns the development of a procedure for systematic searching for mechanisms, classifying them, and screening for the optimum mechanism structure for wobble-plate engines. It includes two parts. The first part is on kinematic structural analysis, including the development of a procedure for the structure classification of 150 mechanisms obtained as a result of an exhaustive search from the prior arts, as disclosed in nearly 1000 patents between 1874 and 1982, and other publications. The second part is on functional analysis, which screens for an optimum design based on a set of judgment criteria. Such optimization criteria are developed in this paper and applied to a group of representative mechanisms derived from the structure analysis. Recommendations such as design guidelines are presented. The general nature of the approach—following the method of separation of kinematic structure and function [1] and combining mathematical approach and design heuristics—is demonstrated here in the case of wobble-plate engine mechanisms and is believed to be useful in type synthesis and design of mechanisms of realistic complexity.

scholarly journals A classification of disulfide patterns and its relationship to protein structure and function

2004 ◽  
Vol 13 (8) ◽  
pp. 2045-2058 ◽  
Author(s):  
Abhas Gupta ◽  
Herman W.T. Van Vlijmen ◽  
Juswinder Singh
Keyword(s):  
Protein Structure ◽  
Structure And Function ◽  
Protein Structure And Function ◽  
And Function
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