Effect of Pulsatile Row and Arterial Line Filtration on Cerebral Cellular Damage During Open-Heart Surgery

1982 ◽  
pp. 362-370 ◽  
Author(s):  
K. M. Taylor
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Cellular Damage ◽  
Arterial Line ◽  
Open Heart

A clinical evaluation of the performance characteristics of one membrane and five bubble oxygenators: gas transfer and gaseous microemboli production

Perfusion ◽  
1986 ◽  
Vol 1 (1) ◽  
pp. 15-27 ◽  
Author(s):  
Derek T Pearson ◽  
Michael P Holden ◽  
Stefan J Poslad ◽  
Alan Murray ◽  
Philip S Waterhouse
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
The Other ◽  
Gas Transfer ◽  
Arterial Line ◽  
Open Heart ◽  
Blood Gas ◽  
Membrane Oxygenator ◽  
Normal Range ◽  
Meaningful Data

The gas transfer characteristics and gaseous microemboli (GME) production of five different bubble oxygenators (Polystan Venotherm, Harvey H-1700, Bentley BIO-10, Gambro 10 and Shiley S-100A HED) and one membrane oxygenator (Cobe CML) have been assessed during standardized clinical perfusion for open-heart surgery in 60 adult patients. The perfusionist attempted to maintain physiological levels of PaCO 2 (5 ± 1 kPa) and PaO2 (12 ± 2 kPa). Only 3% of blood gas values were within the normal range in the Bentley BIO-10 group compared with 17% for the Gambro 10, 20% for the Shiley S-100A HED, 31% for the Polystan Venotherm, 33% for the Cobe CML and 36% for the Harvey H-1700. The number of GME detected in the arterial line was significantly lower in the Cobe CML membrane oxygenator when compared with any of the five different bubble oxygenators (p < 0·001). The Polystan Venotherm released significantly less GME (p < 0·02) than the other oxygenators and the Shiley S-100A HED released significantly more GME (p < 0·02) than the other oxygenators except the Gambro 10. Low gas-blood flow ratios were not necessarily associated with low GME levels and inadequate oxygenation. This study provides meaningful data on which to base the choice of oxygenator, for clinical perfusions.

Clinical evaluation of the LeukoGuard (LG-6) arterial line filter for routine open-heart surgery

Perfusion ◽  
1993 ◽  
Vol 8 (6) ◽  
pp. 489-496 ◽  
Author(s):  
David A Palanzo ◽  
Norman J Manley ◽  
Ralph M Montesano ◽  
Geary L Yeisley ◽  
David Gordon
Keyword(s):  
Clinical Evaluation ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Cost Effective ◽  
The Body ◽  
Experimental Investigations ◽  
Arterial Line ◽  
X Rays ◽  
Open Heart ◽  
Activated Neutrophils

Research has demonstrated that leucocyte depletion diminishes the deleterious effects that activated neutrophils have on the body following cardiopulmonary bypass (CPB). A clinical evaluation involving 36 patients (18 in each group) was conducted to compare the use of the Pall LG-6 (leucocyte-depleting) arterial line filter with the Pall EC PLUS filter for postoperative complications and lung function on routine open-heart cases. No differences were found between the groups for postoperative chest tube drainage, urine output, on bypass platelet drop, chest X-rays, blood usage and circulating elastase levels. Statistically significant differences were observed between immediately post-CPB pO 2 values and ventilator hours (EC PLUS = 13.3, LG-6 = 9.2). Many of the advantages of using leucocyte depletion that have been illustrated through experimental investigations were comparable to our clinical observations. We conclude that using the LG-6 leucocyte-depleting arterial line filter is a cost-effective method to reduce the complications known as 'postperfusion' syndrome.

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

Blood Coagulation Studies and Extracorporeal Circulation in Man

1967 ◽  
Vol 18 (03/04) ◽  
pp. 634-646 ◽  
Author(s):  
N Thurnherr
Keyword(s):  
Blood Coagulation ◽  
Extracorporeal Circulation ◽  
Blood Clotting ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Fibrinolytic System ◽  
Open Heart ◽  
Clotting Factors ◽  
Blood Clotting Factors

SummaryBlood clotting investigations have been executed in 25 patients who have undergone open heart surgery with extracorporeal circulation. A description of alterations in the activity of blood clotting factors, the fibrinolytic system, prothrombin consumption and platelets during several phases of the operation is given.

Open heart surgery in patients with cold agglutinins: Is the fear justified?

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
N Madershahian ◽  
T Wittwer ◽  
J Strauch ◽  
J Wippermann ◽  
UFW Franke ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Cold Agglutinins

Evaluation of Positive Inotropic Drug Effects on Thyroid Hormone Levels after Open Heart Surgery

2015 ◽  
Vol 16 (2) ◽  
pp. 78
Author(s):  
Umit Kervan ◽  
Anil Ozen ◽  
Utku Unal ◽  
Irfan Tasoglu ◽  
Mahmut Mustafa Ulas ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Thyroid Hormone ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Inotropic Drug ◽  
Hormone Levels ◽  
Inotropic Drugs ◽  
Positive Inotropic Drug ◽  
Thyroid Hormone Levels

<p><b>Objective:</b> The aim of this study was to examine the effects of positive inotropic drugs, including adrenaline, dopamine, and dobutamine on thyroid hormone levels following open heart surgery.</p><p><b>Methods:</b> We analyzed free thyroid hormones (FT3 and FT4) and thyroid-stimulating hormones (TSH) in 200 consecutive patients undergoing open heart surgery. Patients were divided into 5 groups according to the inotropic drug administration as follows: Group A (n = 46) received dopamine alone; Group B (n = 40), dopamine and dobutamine; Group C (n = 36), dopamine, dobutamine, and adrenaline; Group D (n = 32), adrenaline alone; and Group E (n = 46), placebo. Procedural factors affecting thyroid hormones were recorded and included cardiopulmonary bypass (CPB) time, cross-clamping time, degree of hypothermia, and the duration and doses of positive inotropic drugs. Blood samples for hormone assays were collected before initiation of inotropic drug therapy (baseline) and postoperatively at 24, 72, and 120 hours after drug therapy.</p><p><b>Results:</b> FT3, FT4, and TSH levels at baseline were similar in all groups. Although there was a trend showing very slight increases in thyroid hormone levels from baseline to the 24th, 72nd, and 120th postoperative hours after drug therapy, these changes were not significant, and there were also no significant differences between the groups. There was also no significant statistical difference in CPB time, cross-clamping time, degree of hypothermia, and duration and doses of positive inotropic drugs between groups.</p><p><b>Conclusion:</b> Although thyroid hormone levels were affected by positive inotropic drug usage after open heart surgery, this effect was not significant and thyroid hormone levels remained within normal ranges.</p>

Electrocardiographic Changes in Open Heart Surgery under Hypothermia

1960 ◽  
Vol 1 (4) ◽  
pp. 397-407
Author(s):  
Hiroshi SATAKE ◽  
Hiromichi TSUCHIOKA ◽  
Osamu MINAMIKAWA ◽  
Toshihito MAEHARA ◽  
Takeshi SHIMIZU
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Electrocardiographic Changes
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