Antiestrogens Old and New: The Search for a Non-Toxic Agent with No Estrogenic Properties

Author(s):  
V. Craig Jordan
Author(s):  
G. S. Agzamova ◽  
M. M. Abdullaeva

The immunological profile of chronic liver lesions depending on the toxic agent was studied. It was revealed that chronic poisoning by industrial toxic substances causes changes in the functional state of the T-system of immunity, long-term contact with industrial chemicals leads to increased sensitization to autoantigens of the body.


2011 ◽  
Vol 64 (5) ◽  
pp. 833-838 ◽  
Author(s):  
Juliana Lourenço de Araújo Veras ◽  
Cintia Regina Tornisiello Katz

This study aimed to assess cases of self-inflicted poisoning among adolescents reported by the Toxicological Care Center of a reference hospital in Recife-PE, Brazil. The data were collected between March and May 2010 from hospital charts and structured interviews with the participants and parents/guardians. Among the 25 cases of attempted suicide registered in the period, 21 were female adolescents, who made up the sample of the present study. The adolescents were between 13 and 19 years of age. Pesticides were the most frequent toxic agent used (61.9%). The results of the present study underscore the importance of studying suicide in this population, with a focus on family relations, in order to lay the foundation for the development of prevention and treatment programs for this vulnerable group.


1979 ◽  
Vol 42 (1) ◽  
pp. 51-54 ◽  
Author(s):  
C. H. WHITE ◽  
S. G. SHILOTRI

Cultures of Streptococcus lactis subsp. diacetylactis and Leuconostoc cremoris were added together in the amount of 0.5% to raw milk in a farm bulk tank. This treatment did not significantly reduce the psychrotrophic or coliform population as hypothesized; however, the shelf-life was extended on products made from this raw milk by an average of 1 day. Also, the legal question of adding viable bacteria to the raw milk needs to be considered by state health departments and appropriate federal agencies. Since hydrogen peroxide is reported to be the toxic agent (to the psychrotrophs) released by the citrate fermenters, the obvious fact is noted that this agent can already be added to milk designed for cheese manufacture.


2005 ◽  
Vol 20 (3) ◽  
pp. 155-158 ◽  
Author(s):  
Amir Krivoy ◽  
Ido Layish ◽  
Eran Rotman ◽  
Avi Goldberg ◽  
Yoav Yehezkelli

AbstractSince the 1995 Tokyo subway sarin attack, terrorist attacks involving weapons of mass destruction or other industrial chemicals present worldwide security and health concerns. On-scene medical triage and treatment in such events is crucial to save as many lives as possible and minimize the deleterious effects of the toxic agent involved. Since there are many chemicals that can be used as potential terrorist weapons, the medical challenge for the emergency medical services (EMS) is a combination of: (1) recognizing that a chemical terrorist attack (non-conventional) has occurred; and (2) identifying the toxic agent followed by proper antidotal treatment. The latter must be done as quickly as possible, preferably on-scene. The most valuable decision at this stage should be whether the agent is organophosphate (OP) or not OP, based on clinical findings observed by pre-trained, first responders. This decision is crucial, since only OP intoxication has readily available, rapidly acting, onscene, specific agents such as atropine and one of the oximes, preferably administered using autoinjectors. Due to the lack of a specific antidote, exposure to other agents (such as industrial chemicals, e.g., chlorine, bromide, or ammonia) should be treated on-scene symptomatically with non-specific measures, such as decontamination and supportive treatment. This paper proposes an algorithm as a cognitive framework for the medical teams on-scene. This algorithm should be part of the medical team's training for preparedness for chemical terrorist attacks, and the team should be trained to use it in drills. Implementing this path of thinking should improve the medical outcome of such an event.


PEDIATRICS ◽  
1996 ◽  
Vol 98 (5) ◽  
pp. 944-947 ◽  
Author(s):  
James A. Bakerink ◽  
Sidney M. Gospe ◽  
Robert J. Dimand ◽  
Marlowe W. Eldridge

Background Hepatic and neurologic injury developed in two infants after ingestion of mint tea. Examination of the mint plants, from which the teas were brewed, indicated that they contained the toxic agent pennyroyal oil. Methods. Sera from each infant were analyzed for the toxic constituents of pennyroyal oil, including pulegone and its metabolite menthofuran. Results. Fulminant liver failure with cerebral edema and necrosis developed in the first infant, who died. This infant was positive only for menthofuran (10 ng/mL). In the other infant, who was positive for both pulegone (25 ng/mL) and menthofuran (41 ng/mL), hepatic dysfunction and a severe epileptic encephalopathy developed. Conclusions. Pennyroyal oil is a highly toxic agent that may cause both hepatic and neurologic injury if ingested. A potential source of pennyroyal oil is certain mint teas mistakenly used as home remedies to treat minor ailments and colic in infants. Physicians should consider pennyroyal oil poisoning as a possible cause of hepatic and neurologic injury in infants, particularly if the infants may have been given home-brewed mint teas.


PEDIATRICS ◽  
1983 ◽  
Vol 72 (3) ◽  
pp. 356-358 ◽  
Author(s):  
◽  

As advances have been made in the care of very low-birth-weight infants, some techniques or practices have caused unexpected complications. One such practice is umbilical vessel catheterization to monitor an infant's arterial blood pressure, infuse fluids and medications, and obtain blood specimens for laboratory examinations. The catheters frequently are flushed with sterile isotonic saline or a 5% solution of dextrose in water, with the flush solution frequently being obtained from a multiple-dose vial. The United States Pharmacopeia requires all medications or solutions marketed in a multiple-dose vial to contain an antimicrobial preservative. Benzyl alcohol, an aromatic alcohol, is used for this purpose in a wide variety of medications and fluids for parenteral therapy, usually in a concentration of 0.9%. Two groups of investigators, Gershanik et al1 (New Orleans) and Brown et al2 (Portland), independently concluded that an intravascular infusion of flush solutions containing 0.9% benzyl alcohol caused severe metabolic acidosis, encephalopathy, respiratory depression with gasping, and perhaps other abnormalities leading to the death of a total of 16 infants. Blood and urine from several affected infants had high levels of both benzoic and hippuric acids, known metabolites of benzyl alcohol. Both groups stated that no additional cases occurred after solutions with benzyl alcohol preservative were banned in their nurseries. Subsequently, in May 1982, the Food and Drug Administration3 with the concurrence of the American Academy of Pediatrics and the Centers for Disease Control,4 urged pediatricians and other personnel in hospitals not to use fluids preserved with benzyl alcohol (or other antimicrobial agents) as intravascular flush solutions for newborn infants and not to use diluents with this preservative to reconstitute or dilute medications for infants.


PEDIATRICS ◽  
1987 ◽  
Vol 79 (5) ◽  
pp. 734-738
Author(s):  
Mark Garber

A 16-month-old child who ingested rat poison, according to her parents, was noted to have signs of cholinergic poisoning. In the emergency department, the child was intubated and given atropine via the endotracheal tube until venous access was established. Phytonadione (vitamin K) and pralidoxime (2-PAM) Were also administered. The child recovered after an uneventful hospital course. The toxic agent was determined to be a carbamate insecticide, for which treatment with pralidoxime is considered controversial. Treatment of cholinergic poisoning due to unknown or mixed agents and poisoning caused by known carbamate insecticides are discussed.


2005 ◽  
Vol 48 (12) ◽  
pp. 3937-3940 ◽  
Author(s):  
Anne Vessières ◽  
Siden Top ◽  
Pascal Pigeon ◽  
Elizabeth Hillard ◽  
Leila Boubeker ◽  
...  

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