Immortal Mammalian Neuronal Stem Cells Differentiate after Implantation into the Developing Brain

1992 ◽  
pp. 76-85 ◽  
Author(s):  
R. D. G. McKay
Keyword(s):  
Stem Cells ◽  
Developing Brain ◽  
Neuronal Stem Cells

scholarly journals Uniaxial stretch-induced axonal injury thresholds for axonal dysfunction and disruption and strain rate effects on thresholds for mouse neuronal stem cells

2017 ◽  
Vol 12 (1) ◽  
pp. 16-00598-16-00598 ◽  
Author(s):  
Evrim KURTOGLU ◽  
Hiromichi NAKADATE ◽  
Kazuhiro KIKUTA ◽  
Shigeru AOMURA ◽  
Akira KAKUTA
Keyword(s):  
Stem Cells ◽  
Strain Rate ◽  
Axonal Injury ◽  
Strain Rate Effects ◽  
Neuronal Stem Cells ◽  
Rate Effects ◽  
Axonal Dysfunction

Limited Ca2+ and PKA-pathway dependent neurogenic differentiation of human adult mesenchymal stem cells as compared to fetal neuronal stem cells

2010 ◽  
Vol 316 (2) ◽  
pp. 216-231 ◽  
Author(s):  
Guilherme Lepski ◽  
Cinthia Elim Jannes ◽  
Jaroslaw Maciaczyk ◽  
Anna Papazoglou ◽  
Alexander T. Mehlhorn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neurogenic Differentiation ◽  
Neuronal Stem Cells ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells ◽  
Pka Pathway

scholarly journals Exosomes from neuronal stem cells may protect the heart from ischaemia/reperfusion injury via JAK1/2 and gp130

2021 ◽  
Author(s):  
Miroslava Katsur ◽  
Zhenhe He ◽  
Vladimir Vinokur ◽  
Randolph Corteling ◽  
Derek M Yellon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Neuronal Stem Cells ◽  
Ischaemia Reperfusion

scholarly journals Cell Signaling in Neuronal Stem Cells

Cells ◽  
2018 ◽  
Vol 7 (7) ◽  
pp. 75 ◽  
Author(s):  
Elkin Navarro Quiroz ◽  
Roberto Navarro Quiroz ◽  
Mostapha Ahmad ◽  
Lorena Gomez Escorcia ◽  
Jose Villarreal ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Mechanisms ◽  
Extrinsic Factors ◽  
Neuronal Stem Cells ◽  
Intrinsic Factors ◽  
Temporal Space ◽  
Current State ◽  
Proliferation And Differentiation ◽  
Asymmetric Divisions ◽  
The Central Nervous System

The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).

scholarly journals LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1821 ◽  
Author(s):  
Panagiotis Karakaidos ◽  
John Verigos ◽  
Angeliki Magklara
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cellular Reprogramming ◽  
Future Perspectives ◽  
Cancer Stemness ◽  
Neuronal Stem Cells ◽  
Lysine Specific Demethylase ◽  
Promising Therapeutic Target ◽  
Exciting Area ◽  
Established Role

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the translational implications for putative epigenetic therapies targeted against them. Accumulating evidence of the effects of epigenetic modulating agents has revealed their dramatic consequences on cellular reprogramming and, particularly, reversing cancer stemness characteristics, such as self-renewal and chemoresistance. Lysine specific demethylase 1 (LSD1/KDM1A) plays a well-established role in the normal hematopoietic and neuronal stem cells. Overexpression of LSD1 has been documented in a variety of cancers, where the enzyme is, usually, associated with the more aggressive types of the disease. Interestingly, recent studies have implicated LSD1 in the regulation of the pool of CSCs in different leukemias and solid tumors. However, the precise mechanisms that LSD1 uses to mediate its effects on cancer stemness are largely unknown. Herein, we review the literature on LSD1’s role in normal and cancer stem cells, highlighting the analogies of its mode of action in the two biological settings. Given its potential as a pharmacological target, we, also, discuss current advances in the design of novel therapeutic regimes in cancer that incorporate LSD1 inhibitors, as well as their future perspectives.

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