scholarly journals Cell Signaling in Neuronal Stem Cells

Cells ◽  
2018 ◽  
Vol 7 (7) ◽  
pp. 75 ◽  
Author(s):  
Elkin Navarro Quiroz ◽  
Roberto Navarro Quiroz ◽  
Mostapha Ahmad ◽  
Lorena Gomez Escorcia ◽  
Jose Villarreal ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Mechanisms ◽  
Extrinsic Factors ◽  
Neuronal Stem Cells ◽  
Intrinsic Factors ◽  
Temporal Space ◽  
Current State ◽  
Proliferation And Differentiation ◽  
Asymmetric Divisions ◽  
The Central Nervous System

The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).

scholarly journals The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies

2019 ◽  
Vol 20 (15) ◽  
pp. 3824 ◽  
Author(s):  
Larisa Ryskalin ◽  
Anderson Gaglione ◽  
Fiona Limanaqi ◽  
Francesca Biagioni ◽  
Pietro Familiari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Treatment Resistance ◽  
Primary Brain Tumor ◽  
Small Subset ◽  
Self Renewal ◽  
Neuronal Stem Cells ◽  
Proliferation And Differentiation ◽  
The Common ◽  
Pluripotency Maintenance

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due to the coexistence of heterogeneous tumor cell populations with different grades of differentiation, and in particular, to a small subset of tumor cells displaying stem cell-like properties. This is the case of glioma stem cells (GSCs), which possess a powerful self-renewal capacity, low differentiation, along with radio- and chemo-resistance. Molecular pathways that contribute to GBM stemness of GSCs include mTOR, Notch, Hedgehog, and Wnt/β-catenin. Remarkably, among the common biochemical effects that arise from alterations in these pathways, autophagy suppression may be key in promoting GSCs self-renewal, proliferation, and pluripotency maintenance. In fact, besides being a well-known downstream event of mTOR hyper-activation, autophagy downregulation is also bound to the effects of aberrantly activated Notch, Hedgehog, and Wnt/β-catenin pathways in GBM. As a major orchestrator of protein degradation and turnover, autophagy modulates proliferation and differentiation of normal neuronal stem cells (NSCs) as well as NSCs niche maintenance, while its failure may contribute to GSCs expansion and maintenance. Thus, in the present review we discuss the role of autophagy in GSCs metabolism and phenotype in relationship with dysregulations of a variety of NSCs controlling pathways, which may provide novel insights into GBM neurobiology.

scholarly journals The differentiation and transdifferentiation of epithelial cells in vitro – is it a new strategy in regenerative biomedicine?

2018 ◽  
Vol 6 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Maurycy Jankowski ◽  
Marta Dyszkiewicz-Konwińska ◽  
Joanna Budna ◽  
Sandra Knap ◽  
Artur Bryja ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Mechanisms ◽  
Proliferative Potential ◽  
Clinical Environment ◽  
Epithelial Stem Cells ◽  
Proliferation And Differentiation ◽  
New Strategy ◽  
Adult Organism ◽  
The Moment

AbstractIn modern medical research, stem cells are one of the main focuses, believed to be able to provide the solution to many currently unsolvable medical cases. However, their extraordinary potential for differentiation creates much obstacles in their potential application in clinical environment, without understanding the whole array of molecular mechanisms that drive the processes associated with their development and maturation. Because of that, there is a large need for studies that concern the most basic levels of those processes. Progenitor stem cells are a favorable target, as they are relatively lineage committed, making the amount of signaling required to reach the final form much lower. Their presence in the adult organism is also an advantage in their potential use, as they can be extracted without the need for storage from the moment of pre-natal development or birth. Epithelial tissues, because of their usual location or function, exhibit extraordinary level of plasticity and proliferative potential. That fact makes them one of the top candidates for use in applications such as tissue engineering, cell based therapies, regenerative and reconstructive medicine. The potential clinical application, however, need to be based on well developed methods, in order to provide an effective treatment without causing major side effects. To achieve that goal, a large amount of research, aiming to analyze the molecular basics of proliferation and differentiation of epithelial stem cells, and stem cells in general, needs to be conducted.

scholarly journals The Role of MicroRNAs in Cardiac Stem Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Nima Purvis ◽  
Andrew Bahn ◽  
Rajesh Katare
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Cardiac Stem Cells ◽  
Cell Therapies ◽  
Small Noncoding Rna ◽  
Proliferation And Differentiation

Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been shown to be an effective option for the source of stem cells. In normal circumstances, CSCs primarily function as a cell store to replace the physiologically depleted cardiovascular cells, while under the diseased condition they have been shown to experimentally regenerate the diseased myocardium. In spite of their major functional role, molecular mechanisms regulating the CSCs proliferation and differentiation are still unknown. MicroRNAs (miRs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Recent studies have demonstrated the important role of miRs in regulating stem cell proliferation and differentiation, as well as other physiological and pathological processes related to stem cell function. This review summarises the current understanding of the role of miRs in CSCs. A deeper understanding of the mechanisms by which miRs regulate CSCs may lead to advances in the mode of stem cell therapies for the treatment of cardiovascular diseases.

scholarly journals Bioinformatics Analysis of Transcriptomic Data Reveals Refined Functional Networks for the Self-Renewal of Mouse Spermatogonial Stem Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Min Wang ◽  
Wene Zhao ◽  
Fuqiang Wang ◽  
Xiufeng Ling ◽  
Daozhen Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Signaling Pathways ◽  
Bioinformatics Analysis ◽  
Cell Types ◽  
Spermatogonial Stem Cells ◽  
Expression Index ◽  
Extrinsic Factors ◽  
Self Renewal ◽  
Proliferation And Differentiation ◽  
Disease Associations

Spermatogonial stem cells (SSCs) are exquisitely regulated to reach a balance between proliferation and differentiation in the niche of seminiferous epithelium. Several extrinsic factors such as GDNF are reported to switch the transition, activating various intrinsic signaling pathways. Transcriptomics analysis could provide a comprehensive landscape of gene expression and regulation. Here, we reanalyzed a previously published transcriptome of two cell types (standing for self-renewing and differentiating SSCs correspondingly). First, we proposed a new parameter, the expression index, to sort the genes considering both absolute and relative expression levels. Using a dynamic statistical model, we identified a list of 1119 candidate genes for SSC self-renewal with the best enrichment of canonical markers. Finally, based on interaction relations, we further optimized the list and constructed a refined network containing integrated information of interactions, expression alternations, biological functions, and disease associations. Further annotation of the 521 refined genes involved in the network revealed an enrichment of well-studied signaling pathways. We believe that the refined network could help us better understand the regulation of SSCs’ fates, as well as find novel regulators or targets for SSC self-renewal or preservation of male fertility.

scholarly journals Microglia: The Real Foe in HIV-1-Associated Neurocognitive Disorders?

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 925
Author(s):  
Ana Borrajo López ◽  
Maria Aránzazu Penedo ◽  
Tania Rivera-Baltanas ◽  
Daniel Pérez-Rodríguez ◽  
David Alonso-Crespo ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Target Cells ◽  
Current State ◽  
Immunodeficiency Virus ◽  
Combined Antiretroviral Therapy ◽  
The Central Nervous System ◽  
Infected Cells ◽  
Hiv 1 ◽  
New Strategies

The current use of combined antiretroviral therapy (cART) is leading to a significant decrease in deaths and comorbidities associated with human immunodeficiency virus type 1 (HIV-1) infection. Nonetheless, none of these therapies can extinguish the virus from the long-lived cellular reservoir, including microglia, thereby representing an important obstacle to curing HIV. Microglia are the foremost cells infected by HIV-1 in the central nervous system (CNS) and are believed to be involved in the development of HIV-1-associated neurocognitive disorder (HAND). At present, the pathological mechanisms contributing to HAND remain unclear, but evidence suggests that removing these infected cells from the brain, as well as obtaining a better understanding of the specific molecular mechanisms of HIV-1 latency in these cells, should help in the design of new strategies to prevent HAND and achieve a cure for these diseases. The goal of this review was to study the current state of knowledge of the neuropathology and research models of HAND containing virus susceptible target cells (microglial cells) and potential pharmacological treatment approaches under investigation.

scholarly journals Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential

2019 ◽  
Vol 17 (6) ◽  
pp. 563-579 ◽  
Author(s):  
Dahua Fan ◽  
Liping Liu ◽  
Zhengzhi Wu ◽  
Meiqun Cao
Keyword(s):  
Neurodegenerative Diseases ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Apoptotic Cell ◽  
Isoquinoline Alkaloid ◽  
Therapeutic Approaches ◽  
Current State ◽  
Progressive Degeneration ◽  
The Central Nervous System ◽  
Low Toxicity

Neurodegenerative diseases are among the most serious health problems affecting millions of people worldwide. Such diseases are characterized by a progressive degeneration and / or death of neurons in the central nervous system. Currently, there are no therapeutic approaches to cure or even halt the progression of neurodegenerative diseases. During the last two decades, much attention has been paid to the neuroprotective and anti-neurodegenerative activities of compounds isolated from natural products with high efficacy and low toxicity. Accumulating evidence indicates that berberine, an isoquinoline alkaloid isolated from traditional Chinese medicinal herbs, may act as a promising anti-neurodegenerative agent by inhibiting the activity of the most important pathogenic enzymes, ameliorating intracellular oxidative stress, attenuating neuroinflammation, triggering autophagy and protecting neurons against apoptotic cell death. This review attempts to summarize the current state of knowledge regarding the therapeutic potential of berberine against neurodegenerative diseases, with a focus on the molecular mechanisms that underlie its effects on Alzheimer’s, Parkinson’s and Huntington’s diseases.

scholarly journals Liver Development, Regeneration, and Carcinogenesis

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Janet W. C. Kung ◽  
Ian S. Currie ◽  
Stuart J. Forbes ◽  
James A. Ross
Keyword(s):  
Stem Cells ◽  
Cell Biology ◽  
Drug Testing ◽  
Molecular Mechanisms ◽  
Embryonic Stem ◽  
Liver Development ◽  
Liver Cancers ◽  
Proliferation And Differentiation ◽  
Induced Pluripotent ◽  
Bioartificial Livers

The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluripotent stem cells into hepatocyte-like cells. As a result, the understanding of the cell biology of proliferation and differentiation in the liver has been improved. This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation. In parallel, the mechanisms regulating cancer cell biology are now clearer, providing fertile soil for novel therapeutic approaches. Recognition of the relationships between development, regeneration, and carcinogenesis, and the increasing evidence for the role of stem cells in all of these areas, has sparked fresh enthusiasm in understanding the underlying molecular mechanisms and has led to new targeted therapies for liver cirrhosis and primary liver cancers.

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