Polymeric Micelles in Dermal and Transdermal Delivery

2016 ◽  
pp. 223-240
Author(s):  
Maria Lapteva ◽  
Michael Möller ◽  
Yogeshvar N. Kalia
Keyword(s):  
Transdermal Delivery ◽  
Polymeric Micelles

Microphase separation in binary polymeric micelles

1988 ◽  
Vol 49 (1) ◽  
pp. 131-137 ◽  
Author(s):  
A. Halperin
Keyword(s):  
Polymeric Micelles ◽  
Microphase Separation

Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats

2018 ◽  
Vol 75 (6) ◽  
pp. 1305-1312
Author(s):  
Liu Zou ◽  
Shujuan Xiong ◽  
Xiangping Deng ◽  
Juan Liu ◽  
Runde Xiong ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Pharmacokinetics And Pharmacodynamics

Formulation and Evaluation of Solubility Enhanced Ciprofloxacin

2013 ◽  
Vol 6 (3) ◽  
pp. 2131-2136
Author(s):  
R S Thakur ◽  
A Nayaz ◽  
Y Koushik
Keyword(s):  
Oral Absorption ◽  
Polymeric Micelles ◽  
In Vitro Release ◽  
Microemulsion System ◽  
Salt Form ◽  
Solubility Study ◽  
Ternary Phase Diagrams ◽  
Blood Ph ◽  
Vitro Release

In the case of solubility limited absorption, creating supersaturation in the GI fluid is very critical as supersaturation may provide great improvement of oral absorption. The techniques to create the so-called supersaturation in the GI fluid include microemulsions, emulsions, liposomes, complexations, polymeric micelles, and conventional micelles. Ciprofloxacin was chosen because it is practically insoluble in water; hence its salt form is used commercially, which is soluble in water. The objective of the present investigation was to enhance the solubility of Ciprofloxacin by formulating it into microemulsion system. For this purpose, initially, surfactant and cosurfactant were selected based on their HLB value, followed by pseudo-ternary phase diagrams to identify the microemulsion existing zone. Different formulations were developed and evaluated for pH, conductivity, in vitro release and stability. Solubility study was performed for optimized formulation. The pH of the designed formulations varied from 6.02-7.04. This was ideal and near blood pH 7.4. Conductivity data indicated that the microemulsion was of the o/w type. In vitro release of optimized formulation(FM3) was 95.2% as compared to pure drug 46.61% after 90 min and marketed product(salt form) 93.9%. Hence, by formulating into microemulsion, the solubility of ciprofloxacin is significantly enhanced.    

Identifying underlying issues related to the inactive excipients of transfersomes based drug delivery system

2020 ◽  
Vol 26 ◽  
Author(s):  
Drashti Patel ◽  
Bappaditya Chatterjee
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Systemic Availability ◽  
Drug Penetration ◽  
Skin Damage ◽  
Variable Effect ◽  
Practical Factors ◽  
Edge Activator

: Transfersomes are bilayer vesicles composed of phospholipid and edge-activators, which are mostly surfactant. Transfersomes based drug delivery system has gained a lot of interest of the pharmaceutical researchers for their ability to improve drug penetration and permeation through the skin. Transdermal drug delivery via transfersomes has the potential to overcome the challenge of low systemic availability. However, this complex vesicular system has different issues to consider for developing a successful transdermal delivery system. One of the major ingredients, phospholipid has versatile sources and variable effect on the vesicle size and drug entrapment in transfersomes. The other one termed as edge-activator or surfactant has some crucial consideration of skin damage and toxicity depending upon its type and concentration. A complex interaction between type and concentration of phospholipid and surfactant was observed, which affect the physicochemical properties of transfersomes. This review focuses on the practical factors related to these two major ingredients such as phospholipid and surfactant. The origin, purity, desired concentration, the susceptibility of degradation, etc. are the important factors for selecting phospholipid. Regarding surfactants, the major aspects are type and desired concentration. A successful development of transfersomes based drug delivery system depends on the proper considerations of these factors and practical aspects.

Formulation and Optimization of Ethosomes for Transdermal Delivery of Ropinirole Hydrochloride

2013 ◽  
Vol 10 (5) ◽  
pp. 500-516 ◽  
Author(s):  
Ashish Mishra ◽  
C. Patel ◽  
Dinesh Shah
Keyword(s):  
Transdermal Delivery ◽  
Ropinirole Hydrochloride
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