Iron Oxide Nanoparticle-Based MRI Contrast Agents: Characterization and In Vivo Use

2016 ◽  
pp. 85-120 ◽  
Author(s):  
F. Herranz ◽  
M. P. Morales ◽  
I. Rodríguez ◽  
J. Ruiz-Cabello
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Iron Oxide Nanoparticle ◽  
Mri Contrast ◽  
Oxide Nanoparticle

scholarly journals Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 567 ◽  
Author(s):  
Hugo Groult ◽  
Isabel García-Álvarez ◽  
Lorenzo Romero-Ramírez ◽  
Manuel Nieto-Sampedro ◽  
Fernando Herranz ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Rat Glioma ◽  
Antimitotic Activity ◽  
Theranostic Agents

The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides. The glycoside-coated IONP micelles were tested as Magnetic Resonance Imaging (MRI) contrast agents as well as antimitotics on rat glioma (C6) and human lung carcinoma (A549) cell lines. Micelle antimitotic activity was compared with the activity of the corresponding free glycosides. In general, all OA-IONP-based micellar formulations of these glycosides maintained their anti-tumor effects, and, in one case, showed an unusual therapeutic improvement. Finally, the micelles presented optimal relaxometric properties for their use as T2-weighed MRI contrast agents. Our results suggest that these bioactive hydrophilic nano-formulations are theranostic agents with synergistic properties obtained from two entities, which separately are not ready for in vivo applications, and strengthen the possibility of using biomolecules as both a coating for OA-IONP micellar stabilization and as drugs for therapy.

One-Step Synthesis of Single-Stranded DNA-Bridged Iron Oxide Supraparticles as MRI Contrast Agents

Nano Letters ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2793-2799
Author(s):  
Jingfang Zhang ◽  
Zhenghan Di ◽  
Husheng Yan ◽  
Yuliang Zhao ◽  
Lele Li
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Single Stranded Dna ◽  
Mri Contrast ◽  
One Step

scholarly journals Study on Establishing Reference Safe Concentrations of MRI Contrast Agents for Optimized Images: Paramagnetic Gd-DTPA-BMEA and Superparamagnetic Ferucarbotran

2021 ◽  
Vol 11 (3) ◽  
pp. 1165
Author(s):  
Wen-Tien Hsiao ◽  
Yi-Hong Chou ◽  
Jhong-Wei Tu ◽  
Ai-Yih Wang ◽  
Lu-Han Lai
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
In Vitro Experiments ◽  
Mri Contrast ◽  
In Vivo Experiments ◽  
Contrast Agent Injection

The purpose of this study is to establish the minimal injection doses of magnetic resonance imaging (MRI) contrast agents that can achieve optimized images while improving the safety of injectable MRI drugs. Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) and ferucarbotran, commonly used in clinical practice, were selected and evaluated with in vitro and in vivo experiments. MRI was acquired using T1-weighted (T1W) and T2-weighted (T2W) sequences, and the results were quantitatively analyzed. For in vitro experiments, results showed that T1W and T2W images were optimal when Gd-DTPA-bisamide (2-oxoethyl) (Gd-DTPA-BMEA) and ferucarbotran were diluted to a volume percentage of 0.6% and 0.05%; all comparisons were significant differences in grayscale statistics using one-way analysis of variance (ANOVA). For in vivo experiments, the contrast agent with optimal concentration percentages determined from in vitro experiments were injected into mice with an injection volume of 100 μL, and the images of brain, heart, liver, and mesentery before and after injection were compared. The statistical results showed that the p values of both T1W and T2W were less than 0.001, which were statistically significant. Under safety considerations for MRI contrast agent injection, optimized MRI images could still be obtained after reducing the injection concentration, which can provide a reference for the safety concentrations of MRI contrast agent injection in the future.

Succinylated heparin monolayer coating vastly increases superparamagnetic iron oxide nanoparticle T2 proton relaxivity

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12905-12914 ◽  
Author(s):  
Manman Xie ◽  
Shijia Liu ◽  
Christopher J. Butch ◽  
Shaowei Liu ◽  
Ziyang Wang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Clinical Use ◽  
History Of ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

Superparamagnetic iron oxide nanoparticles (SPIONs) have a history of clinical use as contrast agents in T2 weighted MRI, though relatively low T2 relaxivity has caused them to fall out of favor as new faster MRI techniques have gained prominence.

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

2016 ◽  
Vol 13 (7) ◽  
pp. 2172-2183 ◽  
Author(s):  
Katie R. Hurley ◽  
Hattie L. Ring ◽  
Michael Etheridge ◽  
Jinjin Zhang ◽  
Zhe Gao ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Iron Oxide Nanoparticle ◽  
Mri Contrast ◽  
Oxide Nanoparticle

scholarly journals Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

2014 ◽  
Vol 16 (3) ◽  
pp. R131 ◽  
Author(s):  
Azza Gramoun ◽  
Lindsey A Crowe ◽  
Lionel Maurizi ◽  
Wolfgang Wirth ◽  
Frank Tobalem ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Dexamethasone Treatment ◽  
Oxide Nanoparticle

scholarly journals Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Christian E. Anderson ◽  
Mette Johansen ◽  
Bernadette O. Erokwu ◽  
He Hu ◽  
Yuning Gu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Ex Vivo ◽  
Single Agent ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Spatiotemporal Resolution ◽  
Mri Contrast ◽  
Contrast Magnetic Resonance

AbstractSynchronous assessment of multiple MRI contrast agents in a single scanning session would provide a new “multi-color” imaging capability similar to fluorescence imaging but with high spatiotemporal resolution and unlimited imaging depth. This multi-agent MRI technology would enable a whole new class of basic science and clinical MRI experiments that simultaneously explore multiple physiologic/molecular events in vivo. Unfortunately, conventional MRI acquisition techniques are only capable of detecting and quantifying one paramagnetic MRI contrast agent at a time. Herein, the Dual Contrast – Magnetic Resonance Fingerprinting (DC-MRF) methodology was extended for in vivo application and evaluated by simultaneously and dynamically mapping the intra-tumoral concentration of two MRI contrast agents (Gd-BOPTA and Dy-DOTA-azide) in a mouse glioma model. Co-registered gadolinium and dysprosium concentration maps were generated with sub-millimeter spatial resolution and acquired dynamically with just over 2-minute temporal resolution. Mean tumor Gd and Dy concentration measurements from both single agent and dual agent DC-MRF studies demonstrated significant correlations with ex vivo mass spectrometry elemental analyses. This initial in vivo study demonstrates the potential for DC-MRF to provide a useful dual-agent MRI platform.

scholarly journals LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis

2020 ◽  
Vol 11 (44) ◽  
pp. 11998-12008
Author(s):  
Alessandro Fracassi ◽  
Jianbo Cao ◽  
Naoko Yoshizawa-Sugata ◽  
Éva Tóth ◽  
Corey Archer ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fluorescent Dyes ◽  
Lipid Nanoparticles ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Mimetic Peptide

LDL-mimetic lipid nanoparticles, decorated with MRI contrast agents and fluorescent dyes, were prepared by the covalent attachments of an apoB100-mimetic peptide, Gd(iii)-chelate, and rhodamine to enhance atherosclerosis in the in vivo imaging.

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