A Laboratory Assessment of Ciprofloxacin and Comparable Antimicrobial Agents

Ciprofloxacin ◽  
1986 ◽  
pp. 3-7
Author(s):  
L. Shrire ◽  
J. Saunders ◽  
R. Traynor ◽  
H. J. Kornhof
1984 ◽  
Vol 3 (4) ◽  
pp. 328-332 ◽  
Author(s):  
L. Shrire ◽  
J. Saunders ◽  
R. Traynor ◽  
H. J. Koornhof

2009 ◽  
pp. 1-8 ◽  
Author(s):  
C. B. Detoni ◽  
E. C. M. Cabral-Albuquerque ◽  
S. V. A. Hohlemweger ◽  
C. Sampaio ◽  
T. F. Barros ◽  
...  

Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.


2019 ◽  
Vol 49 (1/2019) ◽  

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance


2020 ◽  
pp. 42-43
Author(s):  
Andrey S. Khishov ◽  
◽  
Galina I. Burlakova ◽  

Aquaculture production is a promising direction for the development of food production. Like traditional types of animal husbandry, it needs effective medicines for veterinary use, which would ensure not only the well-being of farmed aquatic organisms, but also increase the safety of the fish products and non-fish objects of fishing. The development of measures to control epizootic processes in aquatic organisms is impossible without the creation of new immunological preparations. The development and use of immunobiological drugs will reduce the use of antimicrobial agents. The corresponding set of pharmaceutical drugs was transferred from the traditional veterinary medicine, but due to the peculiarities of the biology of aquatic animals, their immunity and the characteristics of specific pathogens, this could not be done with biological products. The short development time in the aquaculture industry poses current challenges in the form of a lack of basic and applied research for relatively poorly understood groups of new pathogens. The immunological processes associated with the development and intensity of the immune response in aquatic organisms require a detailed study. For domestic aquaculture producers, the analysis and dissemination of the experience accumulated by mankind and the application of advanced developments in this area are even more relevant, since Russia is just beginning its path of intensifying aquaculture production. At the same time, it is clear that the prohibition of the use and monitoring of antimicrobial agents in food products and feed requires a change in the approach to the problem and will lead to the creation of new immunobiological drugs. The market for immunobiological preparations for aquaculture is the most promising for development. In the article, the authors provide data on the development and registration of vaccines for aquaculture in Europe, North and South America.


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