POSTOPERATIVE COMPLIANCE OF BARIATRIC SURGERY PATIENTS REGARDING THE ASSESSMENT OF SERUM LEPTIN LEVELS AND INSULIN RESISTANCE

2019 ◽  
Vol 49 (1/2019) ◽  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Serum Levels ◽  
Medical Laboratory ◽  
Leptin Resistance ◽  
Obese Patients ◽  
Laboratory Assessment ◽  
Serum Leptin ◽  
Before And After ◽  
Bariatric Patients

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance

scholarly journals Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery

2021 ◽  
Vol 10 (10) ◽  
pp. 1326-1336
Author(s):  
Nannan Bian ◽  
Xiaomeng Sun ◽  
Biao Zhou ◽  
Lin Zhang ◽  
Qiu Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Thyroid Function ◽  
Fasting Blood Glucose ◽  
Thyroid Stimulating Hormone ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Free Triiodothyronine ◽  
The Relationship ◽  
Tsh Levels

Objective Bariatric surgery has become the most effective treatment for morbid obesity. Increasing evidence showed that bariatric surgery can alleviate insulin resistance and influence thyroid function. This study aimed to investigate the relationship between changes in thyroid function and adipose tissue insulin resistance (adipo-IR) after bariatric surgery. Methods A total of 287 non-diabetic participants with regular thyroid function were recruited and divided into the lean, overweight and obese groups. Among them, 50 morbidly obese patients submitted to bariatric surgery. Results The obese group had a higher level of adipo-IR, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), FT3/free thyroxine (FT4) and metabolism disorders than the lean and overweight groups. BMI was correlated with TSH, FT3, FT3/FT4 and adipo-IR (r = 0.309, 0.315, 0.322 and 0.651, respectively, all P < 0.001). Adipo-IR was significantly correlated with TSH (r = 0.402, P < 0.001), FT3 (r = 0.309, P < 0.001), and FT3/FT4 (r = 0.228, P < 0.05). Bariatric surgery resulted in a sharp decline in BMI, adipo-IR, TSH, FT3 and FT3/FT4 levels, meanwhile, metabolic disorders improved. The decrease in BMI after bariatric surgery was significantly correlated with reductions in adipo-IR (r = 0.577, P < 0.001) and TSH (r = 0.401, P = 0.005). Interestingly, the fasting blood glucose, fasting insulin, adipo-IR and TSH in the higher TSH group decreased more remarkably than in the lower TSH group. Conclusion Obese individuals with higher TSH levels had an obvious metabolic improvement after bariatric surgery.

Changes In Serum Leptin And Nesfatin-1 Levels Measured Before And After Acupuncture In Overweight/obese Patients: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Tevhid Aydin ◽  
Ruhusen Kutlu ◽  
Hayriye Alp ◽  
Ibrahim Kilinc
Keyword(s):  
Acupuncture Group ◽  
Controlled Study ◽  
Auricular Acupuncture ◽  
Control Group ◽  
Obese Patients ◽  
Health Crisis ◽  
Serum Leptin ◽  
Randomized Controlled ◽  
Control Serum ◽  
Before And After

Obesity has become a global epidemic and public health crisis in our country as well as all over the world.We aimed to investigate the changes in serum leptin and nesfatin-1 levels measured before and after acupuncture in overweight/obese patients. This randomized controlled study was carried out on 90 overweight/obese patients. Participants were divided into three groups: Group 1 (Acupuncture), Group 2 (Diet), and Group 3 (Control). Serum leptin and nesfatin-1 levels were measured before and after the intervention. The 30 days leptin values were significantly decreased in the acupuncture group (p=0.040) while they were significantly increased in the control group (p=0.039). It was detected that the nesfatin-1 values were significantly increased in both acupuncture (p=0.032) and diet groups (p=0.017). Also, body weights significantly decreased both in acupuncture (p=0.032) and diet groups (p<0.001). In the present study, auricular acupuncture was found to be more effective than body acupuncture in reducing body weight. Our results support the effects of acupuncture treatment on appetite hormones. Further research on the mechanisms of endogenous and exogenous actions of the recently discovered hormones leptin and nesfatin-1 isneeded.

scholarly journals Bariatric Surgical Patients' Satisfaction with Nutrition and Dietetic Services in Saudi Hospitals (P10-065-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Elham Aljaaly
Keyword(s):  
Bariatric Surgery ◽  
Decision Making ◽  
Care Plans ◽  
Funding Sources ◽  
Care Services ◽  
Nutrition Care ◽  
Before And After ◽  
Bariatric Patients ◽  
Nutritional Needs ◽  
University Degree

Abstract Objectives The study was conducted to evaluate patient satisfaction and view quality of care and completed nutrition care services they received before and after bariatric surgery. Methods A survey was conducted using a self-completed questionnaire and was administered to bariatric patients. Survey assessed patients’ decision-making for bariatric surgery, patients’ view of their experience of the received nutrition care and the empowerment to follow the prescribed plan. Results Thirty-five patients (30 female and 4 males) completed the questionnaire. The majority of patients were Saudi national (88.6%, n = 31). More patients were holding a university degree (65.7%, n = 23). Bariatric surgery preferences was mostly selected by patients (88.6%, n = 31) with no shared decision-making with surgeons or family members. The decision to undergo bariatric surgery was more likely to be related to health risks issues (65.7%, n = 23) and not for beauty purposes. Patients (34.3%, n = 12) never be seen by a dietitian either before or after surgery, 20%, n = 7 were only seen before surgery or after surgery (17%, n = 6). Nutritional care plans were well explained by a dietitian (RD) to 77.8% of patients (n = 21),13% (n = 3) reported that RDs’ answers to their queries were confusing. Patients 85% (n = 23) find Rds as very cooperative and interactive when manage and plan their nutritional needs. Delivered information are clear and understandable by 87% of patients and all responded patients felt that they were treated with respect by dietitians. Nearly 61% (n = 17) reported that RDs’ involvement in their nutrition care was excellent and 57.1% had excellent overall experience. Twelve patients reported seeing a dietitian throughout their treatment. However, 6 of them saw the dietitian once every month and the rest used to see the dietitian once every 3 months. Conclusions The decision makers including and all Rds will benefit from the results of this study to improve the outcome measures of dietetics services in the scope of bariatric surgery. Funding Sources No Funding Body.

scholarly journals Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery

2018 ◽  
Vol 13 (3) ◽  
pp. 366-375 ◽  
Author(s):  
Jolanta A. Dardzińska ◽  
Łukasz Kaska ◽  
Monika Proczko-Stepaniak ◽  
Maria Szymańska-Gnacińska ◽  
Ewa Aleksandrowicz-Wrona ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Obese Patients ◽  
Desacyl Ghrelin ◽  
Different Types ◽  
Before And After

scholarly journals Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Hanfei Zhu ◽  
Ziqi Ren ◽  
Yan Zang ◽  
Hongxia Hua ◽  
Jinling Lu ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Interleukin 6 ◽  
Meta Analysis ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Serum Levels ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Vitamin B ◽  
Obese Patients

Vitamin deficiency, bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight. It is unclear if microecological preparations benefit obese patients following bariatric surgery. The aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers. We searched seven databases to identify reports published till December 1, 2019, and included randomized controlled trials investigating the effects of microecological preparations in obese adults undergoing bariatric surgery. The primary outcomes included QoL and EWL, while secondary outcomes comprised serum levels of vitamin B12, interleukin 6, TNF-α, and C-reactive protein (CRP). Study bias was analyzed using the Cochrane risk-of-bias tool. Statistical analyses were performed using Review Manager. The mean difference in outcomes was calculated using standardized mean difference (SMD) with a confidence interval (CI) of 95%. A majority of the studies showed a low or moderate risk of bias. Meta-analysis showed significantly higher levels of vitamin B12 in postoperative patients administered with microecological preparations (SMD = 0.52; 95% CI = 0.08–0.95; P=0.02). There were no significant differences in QoL (SMD = −0.14; 95% CI = −0.45–0.17; P=0.38), EWL (SMD = 0.45; 95% CI = −0.16–1.05; P=0.15), and levels of TNF-α (SMD = −0.29; 95% CI = −0.64–0.05; P=0.09), interleukin 6 (SMD = −0.1; 95% CI = −0.81–0.61; P=0.78]), and CRP (SMD = 0.02; 95% CI = −0.32–0.36; P=0.93). The trials examined indicated that microecological preparations had limited efficacy in improving QoL, EWL, and inflammatory response, but they stimulated the synthesis of vitamin B12. This may help in designing efficient microecological preparations to supplement bariatric surgery in obese individuals.

Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery

2019 ◽  
Vol 91 (3) ◽  
pp. 400-410 ◽  
Author(s):  
Judith Brock ◽  
Andreas Schmid ◽  
Thomas Karrasch ◽  
Petra Pfefferle ◽  
Jutta Schlegel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bariatric Surgery ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Serum Levels ◽  
Obese Patients ◽  
Severely Obese ◽  
Visceral Adipose

scholarly journals Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Hang Sun ◽  
Xingchun Wang ◽  
Jiaqi Chen ◽  
Aaron M. Gusdon ◽  
Kexiu Song ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Acanthosis Nigricans ◽  
Resistance Index ◽  
Inflammatory Factors ◽  
Model Assessment ◽  
Obese Patients ◽  
Inflammatory Status ◽  
Before And After ◽  
Matsuda Index

Objective. This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). Methods. A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured. Results. After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21, p<0.05) and fasting insulin (37.09 5 ± 20.26 μU/ml versus 32.10 ± 20.29 μU/ml, p<0.05) were significantly decreased. Matsuda index (2.82 ± 1.54 versus 3.74 ± 2.02, p<0.05) was significantly increased. There were also statistically significant declines in the AN scores of the neck and axilla, body weight, body mass index, body fat, visceral index, neck circumference, waist circumference, and inflammatory markers. Conclusions. It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status. This trial is registered with ClinicalTrials.gov NCT02604095.

scholarly journals Provision of nutritional support to those experiencing complications following bariatric surgery

2010 ◽  
Vol 69 (4) ◽  
pp. 536-542 ◽  
Author(s):  
Ella Segaran
Keyword(s):  
Bariatric Surgery ◽  
Energy Expenditure ◽  
Hospital Admissions ◽  
Nutrition Support ◽  
Considerable Proportion ◽  
Obese Patients ◽  
Free Living ◽  
Protein Requirements ◽  
Before And After ◽  
Oral Diet

This review details the practicalities of providing nutrition support to obese patients who experience complications following bariatric surgery and highlights some of the nutritional challenges encountered by this group of patients. Bariatric surgery to treat morbid obesity has significantly increased internationally over the past decade with hospital admissions rising annually. The gastric bypass is currently the most commonly performed procedure. The complication rate can be up to 16%, with a considerable proportion having nutritional implications. The treatment can involve avoidance of oral diet and nutrition support, i.e. enteral or parenteral nutrition. Opposition to nutrition support can be encountered. It is useful to clarify the aims of nutrition support, these being: the avoidance of overfeeding and its consequences, preservation of lean body mass and promotion of healing. Evidence suggests that hypoenergic nutrition is not harmful and may actually be beneficial. There is a lack of consensus regarding the optimum method to predict the nutritional requirements in the obese acutely unwell patient. The literature suggests that the predicted equations are fairly accurate compared to measured energy expenditure in free living obese patients before and after bariatric surgery. However, these findings cannot be directly applied to those obese patients experiencing complications of bariatric surgery, who will be acutely unwell exhibiting inflammatory response. It is therefore necessary to refer to the literature on energy expenditure in hospitalized obese patients, to help guide practice. More research examining the energy and protein requirements of obese patients needing nutrition support following bariatric surgery is urgently required.

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