Recent Trends of Gelatin Nanoparticles in Biomedical Applications

Author(s):  
Prem Prakash Sharma ◽  
Anshu Sharma ◽  
Pratima R. Solanki
2021 ◽  
Vol 413 (9) ◽  
pp. 2389-2406 ◽  
Author(s):  
Soumyabrata Banik ◽  
Sindhoora Kaniyala Melanthota ◽  
Arbaaz ◽  
Joel Markus Vaz ◽  
Vishak Madhwaraj Kadambalithaya ◽  
...  

AbstractSmartphone-based imaging devices (SIDs) have shown to be versatile and have a wide range of biomedical applications. With the increasing demand for high-quality medical services, technological interventions such as portable devices that can be used in remote and resource-less conditions and have an impact on quantity and quality of care. Additionally, smartphone-based devices have shown their application in the field of teleimaging, food technology, education, etc. Depending on the application and imaging capability required, the optical arrangement of the SID varies which enables them to be used in multiple setups like bright-field, fluorescence, dark-field, and multiple arrays with certain changes in their optics and illumination. This comprehensive review discusses the numerous applications and development of SIDs towards histopathological examination, detection of bacteria and viruses, food technology, and routine diagnosis. Smartphone-based devices are complemented with deep learning methods to further increase the efficiency of the devices.


Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 916 ◽  
Author(s):  
Georges Chedid ◽  
Ali Yassin

Materials science has seen a great deal of advancement and development. The discovery of new types of materials sparked the study of their properties followed by applications ranging from separation, catalysis, optoelectronics, sensing, drug delivery and biomedicine, and many other uses in different fields of science. Metal organic frameworks (MOFs) and covalent organic frameworks (COFs) are a relatively new type of materials with high surface areas and permanent porosity that show great promise for such applications. The current study aims at presenting the recent work achieved in COFs and MOFs for biomedical applications, and to examine some challenges and future directions which the field may take. The paper herein surveys their synthesis, and their use as Drug Delivery Systems (DDS), in non-drug delivery therapeutics and for biosensing and diagnostics.


2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Zhenhai Gan ◽  
Jianhui Ju ◽  
Ting Zhang ◽  
Daocheng Wu

Poly(methacrylic acid) (PMAA)-coated gelatin nanoparticles encapsulated with fluorescent dye rhodamine B were prepared by the coacervation method with the aim to retard the release of rhodamine B from the gelatin matrix. With sodium sulfate as coacervation reagent for gelatin, a kind of biopolymer with excellent biocompatibility, the formed gelatin nanoparticles were cross-linked by formaldehyde followed by the polymerization of methacrylic acid coating. The fluorescent poly(methacrylic acid) coated gelatin (FPMAAG) nanoparticles had a uniform spherical shape and a size distribution of60±5 nm. Infrared spectral analysis confirmed the formation of PMAA coating on the gelatin nanoparticles. Based on UV-Vis spectra, the loading efficiency of rhodamine B for the FPMAAG nanoparticles was 0.26 μg per mg nanoparticles. The encapsulated rhodamine B could sustain for two weeks. Favorable fluorescence property and fluorescence imaging of cells confirmed that the FPMAAG nanoparticles have promising biochemical, bioanalytical, and biomedical applications.


Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1077
Author(s):  
Mostafa Mabrouk ◽  
Diganta B. Das ◽  
Zeinab A. Salem ◽  
Hanan H. Beherei

Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.


e-Polymers ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Tingting Chen ◽  
Tongjiang Cai ◽  
Qiao Jin ◽  
Jian Ji

AbstractFunctional polycaprolactone (PCL) has great potential for applications in biomedical areas. This review summarizes the recent progress in the chemical synthesis of functional PCL. The functional PCL can be synthesized by (a) homopolymerization or copolymerization of functional ε-caprolactone (ε-CL), (b) copolymerization of 2-methylene-1-3-dioxepane with functional vinyl monomers, or (c) copolymerization of ε-CL with functional carbonate monomers. This review presents the recent trends in the synthesis of functional PCL and its biomedical applications.


2017 ◽  
Vol 14 (2) ◽  
pp. 89-99 ◽  
Author(s):  
Saima Wani ◽  
HashAm S Sofi ◽  
Shafquatat Majeed ◽  
Faheem A. Sheikh

Chitosan is a biodegradable, biocompatible and extracellular matrix mimicking polymer. These tunable biological properties make chitosan highly useful in a wide range of applications like tissue-engineering, wound dressing material, controlled drug delivery system, biosensors and membrane separators, and as antibacterial coatings etc. Moreover, its similarity with glycosaminoglycans makes its suitable candidate for tissue-engineering. Electrospinning is a novel technique to manufacture nanofibers of chitosan and these nanofibers possess high porosity and surface area, making them excellent candidates for biomedical applications. However, lack of mechanical strength and water insolubility make it difficult to fabricate chitosan nanofibers scaffolds. This often requires blending with other polymers and use of harsh solvents. Also, the functionalization of chitosan with different chemical moieties provides a solution to these limitations. This article reviews the recent trends and sphere of application of chitosan nanofibers produced by electrospinning process. Further, we present the latest developments in the functionalization of this polymer to produce materials of biological and environmental importance.


2012 ◽  
Vol 69 ◽  
pp. 93-105 ◽  
Author(s):  
David S. Hage ◽  
Jeanethe A. Anguizola ◽  
Cong Bi ◽  
Rong Li ◽  
Ryan Matsuda ◽  
...  

It is aimed to provide an insight on microstrip patch antenna in biomedical applications, the challenges and to discuss the procedure in the way they are dealt so far, in the literature. Microstrip patch antenna gained considerable scientific interest because of its integration with textiles, body mounted applications and medical implants. The ease of integration, confirmability, planar structure, miniaturization, patient safety and biocompatibility make pondering conclusion of intriguing mathematical and experimental paradigm. Simulation tools like HFSS, CST Microwave Studio etc., are being used and the antenna is fabricated after getting satisfactory results. The fabricated antenna is tested under various bio-medical, environmental and mechanical stress and strain conditions. The challenges along with some remedial solution are being discussed with envision to achieve painless, uncomplicated, trustworthy diagnosis and treatment.


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