The Role of Vitamin E Forms in Cancer Prevention and Therapy – Studies in Human Intervention Trials and Animal Models

2011 ◽  
pp. 323-354 ◽  
Author(s):  
Silvia Y. Moya-Camarena ◽  
Qing Jiang
Keyword(s):  
Vitamin E ◽  
Animal Models ◽  
Cancer Prevention ◽  
Human Intervention ◽  
Intervention Trials ◽  
Therapy Studies ◽  
Prevention And Therapy

Mammary stem cells: the root of breast cancer?

2004 ◽  
Vol 7 (9) ◽  
Author(s):  
H. A. Coppock ◽  
R. B. Clarke
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Gland ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Differentiated Cells ◽  
Mammary Stem ◽  
Tissue Specific Stem Cells ◽  
Prevention And Therapy

Tissue-specific stem cells play a key role in organ homoeostasis. They are relatively well characterized in systems which undergo constant proliferation and production of differentiated cells, including the haemopoietic system, skin and intestine. However, little is known about the role and regulation of stem cells in the mammary gland. This review briefly summarizes the current understanding of the role of breast-specific stem cells in normal and cancerous tissues, and how this may identify new targets for breast cancer prevention and therapy.

scholarly journals Phytoestrogens for Cancer Prevention and Treatment

Biology ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 427
Author(s):  
Margalida Torrens-Mas ◽  
Pilar Roca
Keyword(s):  
Cancer Prevention ◽  
Estrogenic Activity ◽  
Structural Similarity ◽  
Secondary Effects ◽  
Treatment Efficiency ◽  
Therapy Efficacy ◽  
Anti Cancer ◽  
Impact On Treatment ◽  
Prevention And Therapy

Phytoestrogens are a large group of natural compounds found in more than 300 plants. They have a close structural similarity to estrogens, which allow them to bind to both estrogen receptors (ER), ERα and ERβ, presenting a weak estrogenic activity. Phytoestrogens have been described as antioxidant, anti-inflammatory, anti-thrombotic, anti-allergic, and anti-tumoral agents. Their role in cancer prevention has been well documented, although their impact on treatment efficiency is controversial. Several reports suggest that phytoestrogens may interfere with the effect of anti-cancer drugs through the regulation of oxidative stress and other mechanisms. Furthermore, some phytoestrogens could exert a protective effect on healthy cells, thus reducing the secondary effects of cancer treatment. In this review, we have studied the recent research in this area to find evidence for the role of phytoestrogens in cancer prevention and therapy efficacy.

A Summary of the Prostate Cancer Prevention Trials With a Focus on the Role of Vitamin E

2012 ◽  
Vol 25 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Fadi Abu-Shahin ◽  
William Stone ◽  
Victoria Ramsauer ◽  
Koyamangalath Krishnan
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Prevention ◽  
Prostate Cancer Prevention ◽  
Prevention Trials

scholarly journals Phytoestrogens for the Management of Endometriosis: Findings and Issues

2021 ◽  
Vol 14 (6) ◽  
pp. 569
Author(s):  
Xia Cai ◽  
Min Liu ◽  
Bing Zhang ◽  
Shao-Jie Zhao ◽  
Shi-Wen Jiang
Keyword(s):  
Animal Models ◽  
Primary Cultures ◽  
Life Quality ◽  
Human Intervention ◽  
Estrogenic Effects ◽  
Critical Issues ◽  
Intervention Trials ◽  
The Relationship

Endometriosis, a chronic disease characterized by recurrent pelvic pain and infertility, severely impacts the health and life quality of many women worldwide. Since phytoestrogens are commonly found in a variety of foods, and estrogen is a major pathological factor for the pathogenesis of endometriosis, their possible involvement cannot be ignored. This review summarizes data on the relationship between phytoestrogen intake and endometriosis risk, and analyzes the findings from in vitro experiments, rodent endometriotic models, and human intervention trials. While favorable results were often obtained from endometrial primary cultures and animal models for resveratrol, isoflavones and puerarin, only resveratrol showed promising results in human intervention trials. Critical issues concerning the current study efforts are discussed: the possible reasons beneath the discrepant observations of estrogenic/anti-estrogenic effects by phytoestrogens; the complicated interplays between phytoestrogens and endogenous estrogens; the shortage of currently used animal models; the necessity to apply reasonable doses of phytoestrogens in experiments. It is expected that the analyses would help to more properly assess the phytoestrogens’ effects on the endometriosis pathogenesis and their potential values for preventive or therapeutic applications.

scholarly journals Berries and oxidative stress markers: an overview of human intervention studies

2015 ◽  
Vol 6 (9) ◽  
pp. 2890-2917 ◽  
Author(s):  
Cristian Del Bo’ ◽  
Daniela Martini ◽  
Marisa Porrini ◽  
Dorothy Klimis-Zacas ◽  
Patrizia Riso
Keyword(s):  
Oxidative Stress ◽  
Intervention Studies ◽  
Human Intervention ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Intervention Trials ◽  
And Oxidative Stress

Severalin vitroandin vivostudies have demonstrated that polyphenol-rich berries may counteract oxidative stress. In this review, we summarized the main finding from human intervention trials on the role of berries in the modulation of markers of oxidative lipid, protein and DNA damage.

scholarly journals The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy

Pancreas ◽  
2015 ◽  
Vol 44 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Yiwei Li ◽  
Vay Liang W. Go ◽  
Fazlul H. Sarkar
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Prevention ◽  
Prevention And Therapy
Sign in / Sign up

Export Citation Format

Share Document