Signaling Pathways Regulating Endothelial Cell-Cell Junctions as a Barrier to Tumor Cell Metastasis

2013 ◽  
pp. 275-289
Author(s):  
Shigetomo Fukuhara ◽  
Naoki Mochizuki
Keyword(s):  
Endothelial Cell ◽  
Tumor Cell ◽  
Signaling Pathways ◽  
Cell Junctions ◽  
Cell Metastasis ◽  
Tumor Cell Metastasis ◽  
Cell Cell

Enhanced Endothelial Cell Retraction Mediated by 12(S)-HETE: A Proposed Mechanism for the Role of Platelets in Tumor Cell Metastasis

1994 ◽  
Vol 210 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Kenneth V. Honn ◽  
Dean G. Tang ◽  
Irma M. Grossi ◽  
Colette Renaud ◽  
Zofia M. Duniec ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Tumor Cell ◽  
Cell Metastasis ◽  
Tumor Cell Metastasis ◽  
Endothelial Cell Retraction ◽  
Cell Retraction

Plasmonic enhanced enzyme activity by catalytic cascade induced mutual benefit tumor starvation/immune/photothermal therapy

2021 ◽  
Author(s):  
Xin Cheng ◽  
Zining Hao ◽  
Shuzhen Chu ◽  
Tiantian Zhang ◽  
Cong Cong ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Tumor Cell ◽  
Signaling Pathways ◽  
Tumor Cells ◽  
Photothermal Therapy ◽  
Mutual Benefit ◽  
Cell Metastasis ◽  
Tumor Cell Metastasis ◽  
Single Tumor

Single tumor starvation therapy can activate other signaling pathways in tumor cells and easily induce tumor cell metastasis.

scholarly journals Caveolae Mediate Growth Factor-induced Disassembly of Adherens Junctions to Support Tumor Cell Dissociation

2009 ◽  
Vol 20 (19) ◽  
pp. 4140-4152 ◽  
Author(s):  
Lidiya Orlichenko ◽  
Shaun G. Weller ◽  
Hong Cao ◽  
Eugene W. Krueger ◽  
Muyiwa Awoniyi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Adherens Junctions ◽  
Adherens Junction ◽  
Cell Contacts ◽  
Caveolin 1 ◽  
Cell Metastasis ◽  
Tumor Cell Metastasis ◽  
E Cadherin ◽  
Cell Cell

Remodeling of cell–cell contacts through the internalization of adherens junction proteins is an important event during both normal development and the process of tumor cell metastasis. Here we show that the integrity of tumor cell–cell contacts is disrupted after epidermal growth factor (EGF) stimulation through caveolae-mediated endocytosis of the adherens junction protein E-cadherin. Caveolin-1 and E-cadherin closely associated at cell borders and in internalized structures upon stimulation with EGF. Furthermore, preventing caveolae assembly through reduction of caveolin-1 protein or expression of a caveolin-1 tyrosine phospho-mutant resulted in the accumulation of E-cadherin at cell borders and the formation of tightly adherent cells. Most striking was the fact that exogenous expression of caveolin-1 in tumor cells that contain tight, well-defined, borders resulted in a dramatic dispersal of these cells. Together, these findings provide new insights into how cells might disassemble cell–cell contacts to help mediate the remodeling of adherens junctions, and tumor cell metastasis and invasion.

scholarly journals Angiomotin Regulates Endothelial Cell-Cell Junctions and Cell Motility

2005 ◽  
Vol 280 (41) ◽  
pp. 34859-34869 ◽  
Author(s):  
Anders Bratt ◽  
Olivier Birot ◽  
Indranil Sinha ◽  
Niina Veitonmäki ◽  
Karin Aase ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Motility ◽  
Cell Junctions ◽  
Cell Cell

scholarly journals Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

2008 ◽  
Vol 6 (3) ◽  
pp. 179-192 ◽  
Author(s):  
Svetlana Stamatovic ◽  
Richard Keep ◽  
Anuska Andjelkovic
Keyword(s):  
Endothelial Cell ◽  
Blood Brain Barrier ◽  
Cell Junctions ◽  
Brain Barrier ◽  
Brain Endothelial Cell ◽  
Blood Brain ◽  
Cell Cell
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