Snake Venom Components as Basis for Biologically Active Synthetic Peptides

2016 ◽  
pp. 1-26
Author(s):  
Igor E. Kasheverov ◽  
Victor I. Tsetlin
Keyword(s):  
Snake Venom ◽  
Synthetic Peptides ◽  
Biologically Active

Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K

Peptides ◽  
2014 ◽  
Vol 57 ◽  
pp. 95-100 ◽  
Author(s):  
Hung-Yun Lin ◽  
Sheng-Huei Yang ◽  
Heng-Yuan Tang ◽  
Guei-Yun Cheng ◽  
Paul J. Davis ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Biologically Active

Long Synthetic Peptides as Biologically Active Proteins: The Example of the Chemokines

Biologicals ◽  
2001 ◽  
Vol 29 (3-4) ◽  
pp. 259-263 ◽  
Author(s):  
Anne-Christine Thierry ◽  
Stéphane Pinaud ◽  
Nicolas Bigler ◽  
Geneviève Perrenoud ◽  
Bérangère Denis ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Biologically Active

Biologically active casein peptides implicated in immunomodulation

1989 ◽  
Vol 56 (3) ◽  
pp. 357-362 ◽  
Author(s):  
D. Migliore-Samour ◽  
F. Floc'h ◽  
P. Jollès
Keyword(s):  
Synthetic Peptides ◽  
Viral Infections ◽  
Milk Proteins ◽  
Biologically Active ◽  
Passive Immunity ◽  
Maternal Milk ◽  
Enzymic Digestion ◽  
Immunomodulating Peptides

SummaryMaternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. Among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. Corresponding synthetic peptides stimulated in vitro phagocytic activity of murine and of human macrophages and exerted in vivo a protective effect against Klebsiella pneumoniae infection of mice. These data suggest that casein peptides may exert a stimulating function on the immune system of the newborn.

scholarly journals Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.

1984 ◽  
Vol 99 (5) ◽  
pp. 1822-1830 ◽  
Author(s):  
J C Boucaut ◽  
T Darribère ◽  
T J Poole ◽  
H Aoyama ◽  
K M Yamada ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Synthetic Peptides ◽  
Neural Crest Cell ◽  
Extracellular Proteins ◽  
Biologically Active ◽  
Recognition Sequence ◽  
Neural Crest Cell Migration ◽  
Crest Cell

We describe a new method for analyzing embryonic events dependent on a specific peptide recognition signal. A short, specific amino acid sequence in fibronectin has been implicated as a recognition site in fibronectin-mediated interactions. Fibroblast adhesion to fibronectin is competitively inhibited by certain synthetic peptides, including the decapeptide Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro, which appears to contain the cell recognition sequence. We found that this peptide inhibited both amphibian gastrulation and avian neural crest cell migration in vivo, as well as the attachment and migration of neural crest cells in vitro. These processes are major cell migratory events previously suggested to involve fibronectin. Negative controls included another conserved fibronectin peptide from the collagen-binding region containing the sequence Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr and another peptide. Our results demonstrate the feasibility of using synthetic peptides directed at recognition sites in extracellular proteins as probes of morphogenetic processes, and they provide further support for the hypothesis that fibronectin is involved in gastrulation and neural crest cell migration.

Myotoxic phospholipases A2 isolated from Bothrops brazili snake venom and synthetic peptides derived from their C-terminal region: Cytotoxic effect on microorganism and tumor cells

Peptides ◽  
2008 ◽  
Vol 29 (10) ◽  
pp. 1645-1656 ◽  
Author(s):  
Tassia R. Costa ◽  
Danilo L. Menaldo ◽  
Clayton Z. Oliveira ◽  
Norival A. Santos-Filho ◽  
Sabrina S. Teixeira ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Snake Venom ◽  
Synthetic Peptides ◽  
Cytotoxic Effect ◽  
Terminal Region ◽  
Phospholipases A2

scholarly journals Glomerular localization of platelet secretory proteins in mesangial proliferative lesions induced by habu snake venom.

1989 ◽  
Vol 37 (7) ◽  
pp. 1075-1082 ◽  
Author(s):  
J L Barnes
Keyword(s):  
Snake Venom ◽  
Mesangial Cells ◽  
Secretory Protein ◽  
Biologically Active ◽  
Secretory Proteins ◽  
Proliferating Cells ◽  
Platelet Factor ◽  
Nodular Lesions ◽  
Platelet Aggregates ◽  
Homogeneous Pattern

Platelets have been implicated in mesangial cell proliferation in experimental and clinical glomerular disease. In this study, the temporal relationship between release of platelet secretory cationic proteins (PSCP) and progression of mesangial hyperplasia was examined in a model of mesangial proliferative glomerulonephritis induced by Habu snake venom (HSV). Intravenous injection of HSV (2 mg/kg body wt) led to capillary dilatation and ballooning into cysts filled with prominent platelet aggregates at 8 hr and 24 hr. At 48 hr, lesions were heterogeneous, some exclusively cystic, others exclusively nodular (comprised of confluent proliferative mesangial cells). Most lesions were mixed, showing features of cystic lesions containing clusters of proliferating cells. At 72 hr, all lesions were exclusively nodular. These lesions were associated with persistent localization of PSCP, as demonstrated by immunofluorescence microscopy. At 8 hr, PSCP were restricted primarily to platelets, became more intensified and diffuse at later time intervals, and by 72 hr was demonstrated in a homogeneous pattern interspaced throughout the nodular lesions. Studies utilizing antiserum to a specific platelet secretory protein, platelet factor 4 (PF4), showed an identical pattern of glomerular localization. Thus, before and during the proliferative phase of nodular formation, mesangial cells are exposed to a milieu replete with PSCP, some of which are presumably biologically active, suggesting a potential role for platelet-secreted proteins in mesangial hyperplasia in this model.

scholarly journals Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi

2021 ◽  
Vol 9 (1) ◽  
pp. 143
Author(s):  
Tecla Ciociola ◽  
Laura Giovati ◽  
Stefania Conti ◽  
Walter Magliani
Keyword(s):  
Synthetic Peptides ◽  
Fungal Pathogens ◽  
Antifungal Agents ◽  
Opportunistic Infections ◽  
Mortality Rates ◽  
Mechanisms Of Action ◽  
Biologically Active ◽  
Malassezia Species ◽  
Etiologic Agents ◽  
Encoding Genes

Mycoses still represent relevant opportunistic infections worldwide, although overshadowed in recent years by other severe and more widespread infections. Moreover, deep-seated mycoses are often accompanied by unacceptably high mortality rates. Etiologic agents include endogenous components of the mycobiota, Candida and Malassezia species above all, and exogenous species, both yeasts and filamentous fungi. Old and new fungal pathogens are increasingly characterized by resistance to the existing antifungal agents, making imperative the search for effective and safe new therapeutics. Among the candidate molecules proposed in recent decades, synthetic peptides derived from the complementarity determining and constant regions of diverse antibodies (Abs), as well as the translated products of Ab-encoding genes, have proved of considerable interest. Their anti-infective activities, regardless of the specificity and isotype of the originating Ab, will be briefly presented and discussed in the light of their different mechanisms of action. Intriguing suggestions on the possible function of Abs after their half-life will be presented, following the recent detection, in human serum, of an antimicrobial Ab-derived peptide. Overall, Abs could represent a source of biologically active, highly flexible peptides, devoid of detectable toxicity, which can be easily synthesized and manipulated to be used, alone or in association with already available drugs, for new anti-infective strategies.

scholarly journals Modification of Alginates to Modulate Their Physic-Chemical Properties and Obtain Biomaterials with Different Functional Properties

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7264
Author(s):  
Piotr Rosiak ◽  
Ilona Latanska ◽  
Paulina Paul ◽  
Witold Sujka ◽  
Beata Kolesinska
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Literature Review ◽  
Functional Properties ◽  
Synthetic Peptides ◽  
Chemical Properties ◽  
Biological Properties ◽  
Biologically Active ◽  
Reaction Conditions ◽  
Wide Range

Modified alginates have a wide range of applications, including in the manufacture of dressings and scaffolds used for regenerative medicine, in systems for selective drug delivery, and as hydrogel materials. This literature review discusses the methods used to modify alginates and obtain materials with new or improved functional properties. It discusses the diverse biological and functional activity of alginates. It presents methods of modification that utilize both natural and synthetic peptides, and describes their influence on the biological properties of the alginates. The success of functionalization depends on the reaction conditions being sufficient to guarantee the desired transformations and provide modified alginates with new desirable properties, but mild enough to prevent degradation of the alginates. This review is a literature description of efficient methods of alginate functionalization using biologically active ligands. Particular attention was paid to methods of alginate functionalization with peptides, because the combination of the properties of alginates and peptides leads to the obtaining of conjugates with properties resulting from both components as well as a completely new, different functionality.

Sign in / Sign up

Export Citation Format

Share Document