Sudden death in patients with intraventricular conduction disorders

Author(s):  
Henri E. Kulbertus
1982 ◽  
Vol 382 (1 Sudden Corona) ◽  
pp. 136-142 ◽  
Author(s):  
Hein J. J. Wellens ◽  
Pedro Brugada ◽  
Frits W. H. M. Bär

2011 ◽  
Vol 7 (5) ◽  
pp. 601-604
Author(s):  
A. A. Chernova ◽  
S. Yu. Nikulina ◽  
S. S. Tret'yakova ◽  
T. I. Ul'yanova

Author(s):  
Hideki Itoh ◽  
Takashi Hisamatsu ◽  
Takuhisa Tamura ◽  
Kazuhiko Segawa ◽  
Toshiaki Takahashi ◽  
...  

Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction disease can cause fatal arrhythmias or sudden death in patients with myotonic dystrophy type 1. Methods and Results This study enrolled 506 patients with myotonic dystrophy type 1 (aged ≥15 years; >50 cytosine‐thymine‐guanine repeats) and was treated in 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow‐up. The cause of death or the occurrence of composite cardiac events (ie, ventricular arrhythmias, advanced atrioventricular blocks, and device implantations) were evaluated as significant outcomes. During a median follow‐up period of 87 months (Q1–Q3, 37–138 months), 71 patients expired. In the univariate analysis, pacemaker implantations (hazard ratio [HR], 4.35; 95% CI, 1.22–15.50) were associated with sudden death. In contrast, PQ interval ≥240 ms, QRS duration ≥120 ms, nutrition, or respiratory failure were not associated with the incidence of sudden death. The multivariable analysis revealed that a PQ interval ≥240 ms (HR, 2.79; 95% CI, 1.9–7.19, P <0.05) or QRS duration ≥120 ms (HR, 9.41; 95% CI, 2.62–33.77, P < 0.01) were independent factors associated with a higher occurrence of cardiac events than those observed with a PQ interval <240 ms or QRS duration <120 ms; these cardiac conduction parameters were not related to sudden death. Conclusions Cardiac conduction disorders are independent markers associated with cardiac events. Further investigation on the prediction of occurrence of sudden death is warranted.


Author(s):  
H. E. Kulbertus ◽  
F. De Leval-Rutten ◽  
M. Dubois ◽  
J. M. Petit

2020 ◽  
Vol 22 (3) ◽  
pp. 41-45
Author(s):  
A. Yu. Kuzmina ◽  
A. A. Blaginin ◽  
A. Ya. Fisun

Abstract. Prevalence and clinical significance of electrocardiography findings was studied in 1189 older pilots in aged 55 years and older, who were consistently admitted to the Central Civil Aviation Hospital (Moscow) and examined on the regular bases. Resting 12-lead electrocardiogram was recorded in all subjects according to generally accepted methods. Normal electrocardiogram was found in 78,5% of older pilots. None of the examined showed signs of myocardial infarction. Minor electrocardiogram abnormalities was registered in 21,5% of pilots. Cardiac conduction disorders were predominated 16,1% of cases, most of them were intraventricular conduction disorders 13,7% of cases. Another electrocardiogram abnormalities were less common 4% of cases. Mixed electrocardiogram abnormalities were noted in a small number of observations in 1,4% of individuals. Thus, older civil aviation pilots are characterized a lower frequency of majority electrocardiogram deviations compared to a population of the same age. The evaluation of fitness to flight in some electrocardiogram deviations is depend of the presence or absence of cardiovascular disease, functional condition of the cardiovascular system and the data of additional examination methods. On the whole, the electrocardiogram use as a screening in asymptomatic individuals has some significant limitations - a number of detected abnormalities may be normal variants, as well as a normal electrocardiogram may be in significant narrowing of the coronary artery. Nevertheless, the need for electrocardiogram recording is recognized by aeromedical specialists of different countries, since this method is exclude a number of pathological changes, which are significant for flight safety.


2020 ◽  
Vol 16 ◽  
Author(s):  
Rose Mary Ferreira Lisboa da Silva ◽  
Alessandra de Souza Maciel

Purpose of review: The purpose of the current mini-review is to describe the importance of surface ECG for the diagnosis of conduction disorder. Methods: The MEDLINE/PubMed database was used, with the keywords "ECG" and "conduction disorders"; over the past 10 years. Other documents were included because of their relevance. Main findings: Data on the anatomy and function of the cardiac electrical system have been described. Conduction disorders including sinus node dysfunction, atrioventricular blocks, intraventricular conduction disorders are exposed as to their epidemiology, etiology, presentation, anatomical site of impaired conduction of the electrical stimulus. The importance of ECG in patients with a cardiac implantable electronic device was also discussed, in addition to future perspectives. Conclusion: Surface ECG allows the diagnosis of atrioventricular and intraventricular conduction disorder and its anatomical block site most of the time, without the need for invasive tests such as electrophysiological study. Dysfunctions of cardiac implantable electronic devices can be diagnosed by ECG, as well as the prediction of response to cardiac resynchronization therapy.


2018 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Mehdi Latif ◽  
Mohammad Salehi ◽  
Nazanin Janfada ◽  
Leila Foroutan ◽  
MohammadMoein Ashrafi

Background: Acute coronary syndrome (ACS) is one of the most common heart diseases. Interventricular conduction disorders are complications of acute myocardial infarctions and have different types, such as left and right bundle branch blocks and left anterior and posterior hemiblocks. The prognosis of this disease can affect therapeutic methods, duration of hospitalization, and timely intervention decisions. Therefore, in this study, we evaluated the relationship between interventricular conduction disorders and the prognosis of patients with ACS.Methods: Using the convenience sampling method, this analytical case-control study was conducted on 140 patients with ACS (61 patients in the case group and 79 patients in the control group) who were treated from March to August 2013. The underlying variables of the risk factors for ACS were evaluated, along with prognostic evaluation factors, in two groups: a case group (patients with interventricular conduction disorders) and a control group (patients without interventricular conduction disorders). Data were analyzed with SPSS v. 17 software using the chi-squared test, the analysis of variance test, Student’s t-test, and Fisher’s exact test. Results: The mean age of patients was 64.1 ± 5.8 years in the case group and 62.9 ± 8.8 years in the control group. No significant relationship was observed between ACS risk factors, such as hyperlipidemia, diabetes, hypertension, previous myocardial infarction, and smoking, and the prognosis of patients with ACS. The mean ejection fraction was 39.7 in the case group and 45.1 in the control group, so a significant relationship existed between the two groups (P<0.05). In addition, systolic heart failure was more common in the case group than in the control group.Conclusion: We found that the presence of auscultation (rales sound) and shortness of breath on the first day of hospital admission in the case group was significantly different from the control group (P<0.05). Furthermore, the ejection fraction in the case group was lower than in the control group, and the frequency of mitral regurgitation in the case group was higher than in the control group. These factors can effectively predict the prognosis of patients with ACS. Finally, we found that interventricular conduction disorders weakened the prognosis of patients with ACS.


2020 ◽  
Vol 22 (2) ◽  
pp. 39-44
Author(s):  
A. Y. Kuzmina ◽  
A. A. Blaginin ◽  
A. Ya Fisun

Prevalence, structure and clinical significance of conduction disturbances was studied according to the electrocardiography findings in 1189 older pilots in aged 55 years and older, who were to the Central Civil Aviation Hospital (Moscow) and examined on the regular bases. Resting electrocardiogram was recorded in all subjects according to generally accepted methods. Heart conduction disorders were detected in 16,9% of pilots of the older age group. More common were intraventricular conduction disturbances - 13,7% of cases, atrioventricular conduction disturbances were recorded less often- 1,8% of cases, and their combination was even less common - 0,6% of cases. Cardiac conduction abnormalities as part of another electrocardiogram syndromes were noted in 10 (0,8%) peoples. Older civil aviation pilots are characterized a lower frequency of electrocardiogram changes compared to a general population of the same age in the Russian Federation. The signs of cardiac conduction disturbances on the electrocardiogram in civil aviation pilots did not always lead to unfitness to fly. The evaluation of fitness to flight in some electrocardiogram deviations is depend of the presence or absence of cardiovascular disease, functional condition of the cardiovascular system and the data of additional examination methods. Diagnosis of heart rhythm and conduction disorders is important in assessing the state of the circulatory system, especially in flight personnel. Timely detection of cardiac conduction disorders in civil aviation pilots is essential for maintaining medical safety, especially in older people. Electrocardiography is performed as an initial method for assessing the state of the conducting heart system in civil aviation pilots.


1988 ◽  
Vol 69 (3A) ◽  
pp. A867-A867
Author(s):  
Q. Timour ◽  
M. Freysz ◽  
L. Bertrix ◽  
P. Couzon ◽  
J. Lang ◽  
...  

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