Pharmacokinetic profile of ketoprofen in elderly subjects

1987 ◽  
pp. 275-276
Author(s):  
W. F. Kean ◽  
H. Howard-Lock ◽  
G. Caille ◽  
J. Bourgouin ◽  
J. Gauthier ◽  
...  
Keyword(s):  
Pharmacokinetic Profile ◽  
Elderly Subjects

Pharmacokinetic Profile and Endocrine Effects of Posatirelin Treatment in Healthy Elderly Subjects

1996 ◽  
Vol 36 (9) ◽  
pp. 823-831 ◽  
Author(s):  
Gianpaolo Reboldi ◽  
Lucilla Parnetti ◽  
Fausto Santeusanio ◽  
Laura Ambrosoli ◽  
Barbara Palumbo ◽  
...  
Keyword(s):  
Pharmacokinetic Profile ◽  
Elderly Subjects ◽  
Endocrine Effects ◽  
Healthy Elderly ◽  
Healthy Elderly Subjects

scholarly journals Pharmacokinetic profile of indoprofen in elderly subjects.

1986 ◽  
Vol 22 (6) ◽  
pp. 721-724
Author(s):  
B Lund ◽  
C Egsmose ◽  
O Knudsen ◽  
RB Andersen
Keyword(s):  
Pharmacokinetic Profile ◽  
Elderly Subjects

scholarly journals Clinafloxacin Pharmacokinetics in Subjects with Various Degrees of Renal Function

2001 ◽  
Vol 45 (9) ◽  
pp. 2536-2542 ◽  
Author(s):  
Edward J. Randinitis ◽  
Jeffery R. Koup ◽  
George Rausch ◽  
Robert Abel ◽  
Nicola J. Bron ◽  
...  
Keyword(s):  
Renal Function ◽  
Severe Renal Impairment ◽  
Pharmacokinetic Profile ◽  
Elderly Subjects ◽  
Open Label ◽  
Pharmacokinetic Profiles ◽  
Age Related ◽  
Elimination Half ◽  
Young Subjects ◽  
Young And Elderly Subjects

ABSTRACT As the primary route for elimination of clinafloxacin is renal clearance (CLR) of unchanged drug, studies were conducted to determine the pharmacokinetic profile of clinafloxacin following administration to young and elderly subjects, subjects with various degrees of renal function, and subjects requiring dialysis. These were open-label studies in which subjects received single oral clinafloxacin doses. Sixteen young subjects (18 to 35 years old) and 16 elderly subjects (>65 years old) were enrolled in a study comparing pharmacokinetic profiles of clinafloxacin in young and elderly subjects. Twenty subjects having various degrees of renal function were enrolled into one of three groups based on degree of renal function as measured by creatinine clearance (CLCR). Twelve subjects with severe renal impairment requiring dialysis enrolled in a third study. Clinafloxacin was generally well tolerated by all subjects. Clinafloxacin pharmacokinetic profiles in elderly subjects were dependent only on age-related decreases in renal function. Clinafloxacin maximum concentrations in plasma, areas under the concentration-time curves, and terminal elimination half-life values increased with decreasing CLCR values. Total apparent body clearance of clinafloxacin from the plasma after oral administration (CLoral) and CLR were dependent on CLCR according to the following relationships: CLoral = 2.3 · CLCR + 77 and CLR = 1.74 · CLCR. Hemodialysis had no significant effect on clinafloxacin clearance. Based on the relationship between CLCR and clinafloxacin CLoral and CLR values, the clinafloxacin dose should be halved in patients having a CLCR of <40 ml/min. Further dose adjustment is not warranted in patients requiring hemodialysis.

Effects of a 6-Week Straw Phonation in Water Exercise Program on the Aging Voice

2020 ◽  
Vol 63 (4) ◽  
pp. 1018-1032
Author(s):  
Chia-Hsin Wu ◽  
Roger W. Chan
Keyword(s):  
Acoustic Analysis ◽  
Vocal Tract ◽  
Exercise Program ◽  
Analysis Of Covariance ◽  
Elderly Subjects ◽  
Control Group ◽  
Perceptual Evaluation ◽  
Positive Effects ◽  
Aging Voice ◽  
Before And After

Purpose Semi-occluded vocal tract (SOVT) exercises with tubes or straws have been widely used for a variety of voice disorders. Yet, the effects of longer periods of SOVT exercises (lasting for weeks) on the aging voice are not well understood. This study investigated the effects of a 6-week straw phonation in water (SPW) exercise program. Method Thirty-seven elderly subjects with self-perceived voice problems were assigned into two groups: (a) SPW exercises with six weekly sessions and home practice (experimental group) and (b) vocal hygiene education (control group). Before and after intervention (2 weeks after the completion of the exercise program), acoustic analysis, auditory–perceptual evaluation, and self-assessment of vocal impairment were conducted. Results Analysis of covariance revealed significant differences between the two groups in smoothed cepstral peak prominence measures, harmonics-to-noise ratio, the auditory–perceptual parameter of breathiness, and Voice Handicap Index-10 scores postintervention. No significant differences between the two groups were found for other measures. Conclusions Our results supported the positive effects of SOVT exercises for the aging voice, with a 6-week SPW exercise program being a clinical option. Future studies should involve long-term follow-up and additional outcome measures to better understand the efficacy of SOVT exercises, particularly SPW exercises, for the aging voice.

Abstract #245 Efficacy and Safety of Semaglutide in Elderly Subjects with Type 2 Diabetes: A Post Hoc Analysis of the Sustain 7 Trial

2018 ◽  
Vol 24 ◽  
pp. 51-52
Author(s):  
Vanita Aroda ◽  
Danny Sugimoto ◽  
David Trachtenbarg ◽  
Mark Warren ◽  
Gurudutt Nayak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Elderly Subjects ◽  
Efficacy And Safety ◽  
Post Hoc Analysis ◽  
Post Hoc

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

Sign in / Sign up

Export Citation Format

Share Document