FT-IR Studies on the T1 State of Chlorophyll a in the Photosystem II Reaction Center And in Vitro

1993 ◽  
pp. 307-308
Author(s):  
T. Noguchi ◽  
Y. Inoue ◽  
K. Satoh
Keyword(s):  
Photosystem Ii ◽  
Chlorophyll A ◽  
Reaction Center ◽  
Ir Studies ◽  
Ft Ir

FT-IR studies on the triplet state of P680 in the photosystem II reaction center: Triplet equilibrium within a chlorophyll dimer

Biochemistry ◽  
1993 ◽  
Vol 32 (28) ◽  
pp. 7186-7195 ◽  
Author(s):  
Takumi Noguchi ◽  
Yorinao Inoue ◽  
Kimiyuki Satoh
Keyword(s):  
Photosystem Ii ◽  
Triplet State ◽  
Reaction Center ◽  
Ir Studies ◽  
Ft Ir

On the Question of the Chlorophyll a Content of the Photosystem II Reaction Center

1994 ◽  
Vol 98 (31) ◽  
pp. 7725-7735 ◽  
Author(s):  
H.-C. Chang ◽  
R. Jankowiak ◽  
N. R. S. Reddy ◽  
C. F. Yocum ◽  
R. Picorel ◽  
...  
Keyword(s):  
Photosystem Ii ◽  
Chlorophyll A ◽  
Reaction Center ◽  
Chlorophyll A Content

scholarly journals Formulation and evaluation of erodible ocular films of Valacyclovir Hydrochloride

2015 ◽  
Vol 13 (1) ◽  
pp. 75-81 ◽  
Author(s):  
KR Naga Priya ◽  
Sayani Bhattacharyya ◽  
P Ramesh Babu
Keyword(s):  
Moisture Absorption ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Corneal Surface ◽  
Elongation At Break ◽  
Ir Studies ◽  
Weight Variation ◽  
Ocular Herpes ◽  
Ft Ir

The present work focuses on formulation of erodible ocular films of valacyclovir hydrochloride (VH) for the treatment of ocular herpes to enhance therapeutic effect through prolonging contact time with the corneal surface. Nine films were prepared by solvent casting method using different ratios of polymers HPMC E 15 LV and PVP. The FT-IR studies showed no interaction between drug and the polymers. Developed formulations were evaluated for tensile strength, % elongation at break, strain, folding endurance, uniformity of thickness, weight variation, % moisture absorption, surface pH, drug content, in vitro release, kinetics study, sterility test and eye irritancy test on Rabbit eye. On the basis of these evaluations it was found that with increase in hydrophilic polymer content the mechanical properties and release rate of the films were improved. The kinetic study revealed case II transport. The eye irritancy test showed that the films were free from ocular toxicity and irritancy. DOI: http://dx.doi.org/10.3329/dujps.v13i1.21866 Dhaka Univ. J. Pharm. Sci. 13(1): 75-81, 2014 (June)

scholarly journals EFFECT OF MENTHOL ON THE TRANSDERMAL PERMEATION OF ACECLOFENAC FROM MICROEMULSION FORMULATION

2019 ◽  
pp. 117-122
Author(s):  
Abdul Baquee Ahmed ◽  
Gouranga Das
Keyword(s):  
Droplet Size ◽  
Skin Permeation ◽  
Peak Height ◽  
Skin Permeability ◽  
Permeability Barrier ◽  
Microemulsion Formulation ◽  
Transdermal Permeation ◽  
Ir Studies ◽  
Ft Ir

Objective: The aim of this investigation was to enhance the transdermal permeation of aceclofenac (ACF) from microemulsion formulation using menthol as a natural permeation enhancer. Methods: Microemulsion containing 2% w/v of ACF was prepared by a titration method with different concentration of oil, surfactant and co-surfactant. The prepared microemulsion was evaluated for droplet size, viscosity, pH and in vitro skin permeation studies. Menthol at 3-8% w/w was added to the selected microemulsion formulation and their effect on skin permeation was evaluated across rat epidermis using modified Keshary-Chien diffusion cell. The Fourier transform infrared spectroscopy (FT-IR) was performed to understand the regulation action of menthol in the skin permeability barrier. Results: The average droplet size of the microemulsion was found to be 89.4±2.12 to 175.2±3.10 nm. The transdermal flux of the microemulsion containing 8% w/w menthol showed 2.9 fold increases in transdermal flux of ACF compared with the formulation without menthol. Result of FT-IR studies showed decrease in peak height of the symmetric and asymmetric C-H stretching vibrations may be because of the extraction of the stratum corneum (SC) lipids and the alteration of the skin permeability barrier. Conclusion: This result suggests that menthol significantly enhanced the transdermal permeation of ACF and may be an effective natural penetration enhancer for transdermal delivery of the drug.

scholarly journals Formulation, characterization and evaluation of Tramadol Hydrochloride Hydrogel

2020 ◽  
Vol 10 (5-s) ◽  
pp. 177-185
Author(s):  
Vipin Kumar ◽  
Kapil Malviya ◽  
Lavakesh Kumar Omray
Keyword(s):  
Vital Role ◽  
Tramadol Hydrochloride ◽  
Ir Studies ◽  
In Vitro Permeation ◽  
Ft Ir ◽  
Solubility Determination ◽  
Preclinical And Clinical Studies ◽  
Drug Efficiency ◽  
Gel Formulations

The challenge in the formulation of novel systems for TDDS is to identify technologies and formulation excipients which simultaneously optimize drug permeation. Our main goal was to design and evaluate a recent alternative for the administration of tramadol HCl. Performed the preformulation study as different evaluation parameters Physiochemical Studies, Solubility Determination, Partition Coefficient, and Preparation of Calibration Curve simultaneously Preparation & Characterization of Hydrogel Formulation Homogeneity, pH Measurement, Drug Content, Viscosity, Spreadability, In-Vitro Permeation, FT-IR Studies. Results revealed that the present investigation, tramadol was successfully incorporated into different gel formulations. Among all gel formulations, tramadol gel (F13) proved to be the formula of choice, showing good characteristics and controlling the drug release for long period of time. Gel formulation F13 could be very promising and innovative topical alternative for pain management and arthritis and play a vital role in drug efficiency. These findings may open new avenues for the treatment through dermal by local application of tailored gel. However, further preclinical and clinical studies are recommended to support its efficiency claims in humans. Keywords: Tramadol HCl; In-Vitro Permeation; Hydrogel; FT-IR Studies; Characterization

Design and Development of Mupirocin Nanofibers as Medicated Textiles for Treatment of Wound Infection in Secondary Burns

2021 ◽  
Vol 14 (6) ◽  
pp. 5672-5682
Author(s):  
Ruchi Tiwari ◽  
Akanksha Lahiri ◽  
Gaurav Tiwari ◽  
Ramachandran Vadivelan
Keyword(s):  
High Stability ◽  
Solvent Casting ◽  
Topical Drug Delivery ◽  
Stability Studies ◽  
Scanning Calorimetry ◽  
Electrospinning Technique ◽  
Ir Studies ◽  
Permeation Studies ◽  
Ft Ir

The present study assessed the topical potential of nanofibers loaded with Mupirocin (MUP) for the treatment of burns. Nanofibers of MUP were composed of Polyvinyl Pyrrolidone (PVP), Gelatin Type-A, and Ethanol using two methods: Solvent casting and Electrospinning. Nanofibers were characterized for Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), Drug Content Studies, in-vitro drug permeation, antibacterial and stability studies. The FT-IR studies showed that the Electrospinning technique had a very good mixing of MUP with the polymer. SEM studies showed that the morphology of electrospinning nanofibers had diameters in the range of 70.41 nm- 406.83 nm. The thermal decomposition studies of optimized Nanofiber (E.S.1) were performed by DSC and TGA study and it was found that the formulation had high stability in high-temperature environments. Permeation studies showed that E.S.1 had the highest percentage amount and controlled release of the drug (90 %) up to 8 has compared to other formulations. Nanofibers prepared through the Electrospinning technique showed better antibacterial activity against Staphylococcus aureus as compared to the Solvent casting nanofibers. This research suggested that MUP loaded nanofibers can be potentially used as a topical drug delivery system for the treatment of burns. 

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