Smoluchowski-Vlasov Equations, Reference Memory Function Approximation, and Molecular Models for Transport and Relaxation in Fluids

The ability of the perturbation model (Jones & Wearden, 2003) to account for reference memory function in a visual temporal generalization task and auditory and visual reproduction tasks was examined. In all tasks the number of presentations of the standard was manipulated (1, 3, or 5), and its effect on performance was compared. In visual temporal generalization the number of presentations of the standard did not affect the number of times the standard was correctly identified, nor did it affect the overall temporal generalization gradient. In auditory reproduction there was no effect of the number of times the standard was presented on mean reproductions. In visual reproduction mean reproductions were shorter when the standard was only presented once; however, this effect was reduced when a visual cue was provided before the first presentation of the standard. Whilst the results of all experiments are best accounted for by the perturbation model there appears to be some attentional benefit to multiple presentations of the standard in visual reproduction.

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Transport properties in the zero order gaussian memory function approximation with phase integrals evaluated from Monte Carlo calculations

Molecular Physics ◽

10.1080/00268978300100701 ◽

1983 ◽

Vol 48 (5) ◽

pp. 989-1002 ◽

Cited By ~ 13

Author(s):

M. Luckas ◽

K. Lucas

Keyword(s):

Monte Carlo ◽

Transport Properties ◽

Function Approximation ◽

Memory Function ◽

Zero Order ◽

Monte Carlo Calculations

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Perturbation theory for the viscosity of molecular liquids and liquid mixtures based on the zero order gaussian memory function approximation

Molecular Physics ◽

10.1080/00268978500100191 ◽

1985 ◽

Vol 54 (1) ◽

pp. 225-243 ◽

Cited By ~ 3

Author(s):

M. Luckas ◽

K. Lucas

Keyword(s):

Perturbation Theory ◽

Function Approximation ◽

Memory Function ◽

Liquid Mixtures ◽

Zero Order ◽

Molecular Liquids

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PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain

BioMed Research International ◽

10.1155/2016/6945415 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 11

Author(s):

Ilhan Lim ◽

Hye-Young Joung ◽

A Ram Yu ◽

Insop Shim ◽

Jin Su Kim

Keyword(s):

Cognitive Impairment ◽

Glucose Metabolism ◽

Cognitive Deficits ◽

Parietal Lobe ◽

Memory Function ◽

Reference Memory ◽

Neural Mechanisms ◽

Learning Ability ◽

Positron Emission ◽

Number Of Patients

A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy. In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET). We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments. According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus. Reduced glucose metabolism was more prominent after treatment with doxorubicin than cyclophosphamide. Our results demonstrated the neural mechanisms for cognitive impairment after chemotherapy and show that cognition was improved after donepezil intervention using both behavioral and imaging methods. Our results suggested that donepezil can be employed clinically for the treatment of cognitive deficits after chemotherapy.

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Continuous VA deficiency during postnatal development decreases rat learning and memory function via excitatory Ca2+neuron

Cell Biology International ◽

10.1042/cbi034s018a ◽

2010 ◽

Vol 34 (8) ◽

pp. S18-S18

Author(s):

Wei Jiang ◽

Enyi Wen ◽

Min Gong ◽

Yang Bi ◽

Xiaojuan Zhang ◽

...

Keyword(s):

Postnatal Development ◽

Learning And Memory ◽

Memory Function

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Folate and vitamin B-12 deficiencies additively impaired memory function and disturbed the gut microbiota in amyloid-β infused rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000624 ◽

2019 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Sunmin Park ◽

Sunna Kang ◽

Da Sol Kim

Keyword(s):

Insulin Resistance ◽

Gut Microbiota ◽

Insulin Signaling ◽

Gut Microbiome ◽

Metabolic Diseases ◽

Memory Function ◽

Amyloid Β ◽

Impaired Memory ◽

Ca1 Region ◽

Folate And Vitamin B12

Abstract. Folate and vitamin B12(V-B12) deficiencies are associated with metabolic diseases that may impair memory function. We hypothesized that folate and V-B12 may differently alter mild cognitive impairment, glucose metabolism, and inflammation by modulating the gut microbiome in rats with Alzheimer’s disease (AD)-like dementia. The hypothesis was examined in hippocampal amyloid-β infused rats, and its mechanism was explored. Rats that received an amyloid-β(25–35) infusion into the CA1 region of the hippocampus were fed either control(2.5 mg folate plus 25 μg V-B12/kg diet; AD-CON, n = 10), no folate(0 folate plus 25 μg V-B12/kg diet; AD-FA, n = 10), no V-B12(2.5 mg folate plus 0 μg V-B12/kg diet; AD-V-B12, n = 10), or no folate plus no V-B12(0 mg folate plus 0 μg V-B12/kg diet; AD-FAB12, n = 10) in high-fat diets for 8 weeks. AD-FA and AD-VB12 exacerbated bone mineral loss in the lumbar spine and femur whereas AD-FA lowered lean body mass in the hip compared to AD-CON(P < 0.05). Only AD-FAB12 exacerbated memory impairment by 1.3 and 1.4 folds, respectively, as measured by passive avoidance and water maze tests, compared to AD-CON(P < 0.01). Hippocampal insulin signaling and neuroinflammation were attenuated in AD-CON compared to Non-AD-CON. AD-FAB12 impaired the signaling (pAkt→pGSK-3β) and serum TNF-α and IL-1β levels the most among all groups. AD-CON decreased glucose tolerance by increasing insulin resistance compared to Non-AD-CON. AD-VB12 and AD-FAB12 increased insulin resistance by 1.2 and 1.3 folds, respectively, compared to the AD-CON. AD-CON and Non-AD-CON had a separate communities of gut microbiota. The relative counts of Bacteroidia were lower and those of Clostridia were higher in AD-CON than Non-AD-CON. AD-FA, but not V-B12, separated the gut microbiome community compared to AD-CON and AD-VB12(P = 0.009). In conclusion, folate and B-12 deficiencies impaired memory function by impairing hippocampal insulin signaling and gut microbiota in AD rats.

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Impact of Comorbid Depression on Serial Position Effects in Alzheimer’s Disease

GeroPsych ◽

10.1024/1662-9647/a000115 ◽

2014 ◽

Vol 27 (4) ◽

pp. 161-169 ◽

Cited By ~ 1

Author(s):

Nienke A. Hofrichter ◽

Sandra Dick ◽

Thomas G. Riemer ◽

Carsten Schleussner ◽

Monique Goerke ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Serial Position ◽

Episodic Memory ◽

Memory Performance ◽

Memory Function ◽

Word List ◽

Position Effects ◽

Serial Position Effects ◽

List Memory

Hippocampal dysfunction and deficits in episodic memory have been reported for both Alzheimer’s disease (AD) and major depressive disorder (MDD). Primacy performance has been associated with hippocampus-dependent episodic memory, while recency may reflect working memory performance. In this study, serial position profiles were examined in a total of 73 patients with MDD, AD, both AD and MDD, and healthy controls (HC) by means of CERAD-NP word list memory. Primacy performance was most impaired in AD with comorbid MDD, followed by AD, MDD, and HC. Recency performance, on the other hand, was comparable across groups. These findings indicate that primacy in AD is impaired in the presence of comorbid MDD, suggesting additive performance decrements in this specific episodic memory function.

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