Production of Adventitious Root Biomass and Bioactive Compounds from Hypericum perforatum L. Through Large Scale Bioreactor Cultures

2014 ◽  
pp. 251-283 ◽  
Author(s):  
Xi-Hua Cui ◽  
Hosakatte Niranjana Murthy ◽  
Kee-Yoeup Paek
Keyword(s):  
Bioactive Compounds ◽  
Adventitious Root ◽  
Root Biomass ◽  
Large Scale ◽  
Hypericum Perforatum ◽  
Bioreactor Cultures ◽  
Hypericum Perforatum L ◽  
Large Scale Bioreactor

Production of adventitious root biomass and secondary metabolites of Hypericum perforatum L. in a balloon type airlift reactor

2011 ◽  
Vol 102 (21) ◽  
pp. 10072-10079 ◽  
Author(s):  
Xi-Hua Cui ◽  
Hosakatte Niranjana Murthy ◽  
You-Xun Jin ◽  
Yong-Hyeon Yim ◽  
Ji-Yeong Kim ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Adventitious Root ◽  
Root Biomass ◽  
Hypericum Perforatum ◽  
Airlift Reactor ◽  
Hypericum Perforatum L

scholarly journals The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe

Genes ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 1210
Author(s):  
Paride Rizzo ◽  
Lothar Altschmied ◽  
Beena M. Ravindran ◽  
Twan Rutten ◽  
John C. D’Auria
Keyword(s):  
Bioactive Compounds ◽  
Genetic Basis ◽  
Hypericum Perforatum ◽  
State Of The Art ◽  
Antidepressant Activity ◽  
Medical Applications ◽  
The World ◽  
Medicinal Crops ◽  
Hypericum Perforatum L ◽  
Important Medicinal Plant

Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extracts motivate a multi-billion dollar industry around the world, the scientific interest centers around the biosynthetic pathways of hyperforin and hypericin and their medical applications. Here, we focus on what is known about these processes and evaluate the possibilities of combining state of the art omics, genome editing, and synthetic biology to unlock applications that would be of great value for the pharmaceutical and medical industries.

scholarly journals The Influence of Hypericum perforatum L. Addition to Wheat Cookies on Their Antioxidant, Anti-Metabolic Syndrome, and Antimicrobial Properties

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1379
Author(s):  
Anna Jakubczyk ◽  
Kaja Kiersnowska ◽  
Begümhan Ömeroğlu ◽  
Urszula Gawlik-Dziki ◽  
Krzysztof Tutaj ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bioactive Compounds ◽  
Hypericum Perforatum ◽  
Antimicrobial Properties ◽  
Inhibitory Effect ◽  
Absorption Capacity ◽  
In Vitro Hydrolysis ◽  
Gastrointestinal Conditions ◽  
Hypericum Perforatum L

The aim of this study was to characterize wheat cookies enriched with 0.5% and 1.0% of Hypericum perforatum L. (St. John’s wort, SJW) and determine their pro-health properties in vitro after hydrolysis in simulated gastrointestinal conditions. The results indicated that 1.0 SJW was characterized by the highest content of polyphenols, flavonoids, and phenolic acids (2.32 mg mL−1, 4.93 µg mL−1, and 12.35 µg mL−1, respectively). The enriching cookies had no effect on water absorption capacity (WAC) and oil absorption capacity (OAC). After in vitro hydrolysis, the highest peptide content was noted in 1.0 SJW (0.52 mg mL−1), and the bioactive compounds were characterized by high potential bioaccessibility (PAC), but poor bioavailability (PAV). The addition of SJW increased the ACE, α-amylase, and LOX inhibitory effect, but reduced the inhibition of pancreatic lipase. The highest antioxidant activity was noted for 1.0 SJW. The results showed that only 0.5 SJW and 1.0 SJW had slight antimicrobial activity against E. coli ATCC 25922 and B. cereus ATCC 14579 with MIC = 12.5 mg mL−1. Fractions with molecular mass <3.0 kDa were characterized with the highest p-coumaric acid content. The results show that SJW cookies had a higher content of bioactive compounds and more potent anti-metabolic syndrome effects.

St. John’s wort (Hypericum perforatum L.): Challenges and strategies for production of chemically-consistent plants

2006 ◽  
Vol 86 (3) ◽  
pp. 765-771 ◽  
Author(s):  
Susan J. Murch ◽  
Praveen K. Saxena
Keyword(s):  
Medicinal Plant ◽  
Large Scale ◽  
Hypericum Perforatum ◽  
Controlled Environment ◽  
Natural Health Products ◽  
Scale Production ◽  
Plant Products ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Plants are by far the most important source of natural therapeutics, and the role of plants in enhancing the longevity and the quality of life is increasingly accepted throughout the world. A series of problems with medicinal plant products, such as contamination with biological and environmental pollutants, quantitative and qualitative variations of bioactive compounds, adulteration with misidentified species, and the concern of unsustainable harvest, has prompted the introduction of regulations to ensure the quality and safety of medicinal plant products in Canada. In the future, Natural Health Products in Canada will be manufactured to a new standard of quality and these changes in the industry have necessitated new approaches to the breeding, production, and processing of medicinal plant tissues. The continuing growth in the medicinal plant marketplace has also brought about the challenge of maintaining a balance between consumer demand and the need to protect medicinal biodiversity. St. John’s wort (Hypericum perforatum L.) is one of the most popular medicinal plants with a history of use spanning more than two millennia and modern studies demonstrating efficacy. However, inconsistencies in the results of various clinical trials and difficulties in identifying a specific medicinal molecule with defined pharmaceutical function prompted our efforts to improve St. John’s wort products. Development of elite varieties with predictable phytochemical profiles, mass clonal propagation in vitro, large-scale production in sterile environments and controlled environment production systems, have been combined to produce a new standard in the production of St. John’s wort. Key words: St. John's wort, chemical consistency, hyperforin, melatonin, controlled environment systems

scholarly journals NF-κB Inhibition and PPAR Activation by Phenolic Compounds from Hypericum perforatum L. Adventitious Root

2013 ◽  
Vol 34 (5) ◽  
pp. 1407-1413 ◽  
Author(s):  
Wei Li ◽  
Yan Ding ◽  
Tran Hong Quang ◽  
Thi Thanh Ngan Nguyen ◽  
Ya Nan Sun ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Adventitious Root ◽  
Hypericum Perforatum ◽  
Hypericum Perforatum L

Variation in concentrations of major bioactive compounds in Hypericum perforatum L. from Lithuania

2012 ◽  
Vol 35 (1) ◽  
pp. 302-308 ◽  
Author(s):  
Edita Bagdonaitė ◽  
Pavol Mártonfi ◽  
Miroslav Repčák ◽  
Juozas Labokas
Keyword(s):  
Bioactive Compounds ◽  
Hypericum Perforatum ◽  
Hypericum Perforatum L

Quantitation of oligomeric procyanidin clusters with defined degree of polymerisation from Hypericum perforatum L.

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
N Hellenbrand ◽  
F Petereit ◽  
M Lechtenberg ◽  
A Hensel
Keyword(s):  
Hypericum Perforatum ◽  
Degree Of Polymerisation ◽  
Hypericum Perforatum L

Determination of Hypericin in St. John's Wort (Hypericum perforatum L.) extracts using HPLC-ED

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
E Sofic ◽  
A Copra Janicijevic ◽  
M Maksimovic ◽  
I Tahirovic ◽  
L Klepo ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L
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