Pilot-Scale Culture of Hypericum Perforatum L. Adventitious Roots in Airlift Bioreactors for the Production of Bioactive Compounds

2014 ◽  
Vol 174 (2) ◽  
pp. 784-792 ◽  
Author(s):  
Xi-Hua Cui ◽  
Hosakatte Niranjana Murthy ◽  
Kee-Yoeup Paek
Keyword(s):  
Bioactive Compounds ◽  
Adventitious Roots ◽  
Hypericum Perforatum ◽  
Pilot Scale ◽  
Airlift Bioreactors ◽  
Hypericum Perforatum L

Development of a low-cost disposable bioreactor for pilot scale production of Hypericum perforatum L. adventitious roots

2020 ◽  
pp. 113096
Author(s):  
Ahmad Sobhani ◽  
Morteza Khanahmadi ◽  
Ali Jalali ◽  
Kosar Moradi ◽  
Nafiseh Noormohammadi ◽  
...  
Keyword(s):  
Adventitious Roots ◽  
Hypericum Perforatum ◽  
Low Cost ◽  
Pilot Scale ◽  
Scale Production ◽  
Disposable Bioreactor ◽  
Pilot Scale Production ◽  
Hypericum Perforatum L

scholarly journals The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe

Genes ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 1210
Author(s):  
Paride Rizzo ◽  
Lothar Altschmied ◽  
Beena M. Ravindran ◽  
Twan Rutten ◽  
John C. D’Auria
Keyword(s):  
Bioactive Compounds ◽  
Genetic Basis ◽  
Hypericum Perforatum ◽  
State Of The Art ◽  
Antidepressant Activity ◽  
Medical Applications ◽  
The World ◽  
Medicinal Crops ◽  
Hypericum Perforatum L ◽  
Important Medicinal Plant

Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extracts motivate a multi-billion dollar industry around the world, the scientific interest centers around the biosynthetic pathways of hyperforin and hypericin and their medical applications. Here, we focus on what is known about these processes and evaluate the possibilities of combining state of the art omics, genome editing, and synthetic biology to unlock applications that would be of great value for the pharmaceutical and medical industries.

scholarly journals The Influence of Hypericum perforatum L. Addition to Wheat Cookies on Their Antioxidant, Anti-Metabolic Syndrome, and Antimicrobial Properties

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1379
Author(s):  
Anna Jakubczyk ◽  
Kaja Kiersnowska ◽  
Begümhan Ömeroğlu ◽  
Urszula Gawlik-Dziki ◽  
Krzysztof Tutaj ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bioactive Compounds ◽  
Hypericum Perforatum ◽  
Antimicrobial Properties ◽  
Inhibitory Effect ◽  
Absorption Capacity ◽  
In Vitro Hydrolysis ◽  
Gastrointestinal Conditions ◽  
Hypericum Perforatum L

The aim of this study was to characterize wheat cookies enriched with 0.5% and 1.0% of Hypericum perforatum L. (St. John’s wort, SJW) and determine their pro-health properties in vitro after hydrolysis in simulated gastrointestinal conditions. The results indicated that 1.0 SJW was characterized by the highest content of polyphenols, flavonoids, and phenolic acids (2.32 mg mL−1, 4.93 µg mL−1, and 12.35 µg mL−1, respectively). The enriching cookies had no effect on water absorption capacity (WAC) and oil absorption capacity (OAC). After in vitro hydrolysis, the highest peptide content was noted in 1.0 SJW (0.52 mg mL−1), and the bioactive compounds were characterized by high potential bioaccessibility (PAC), but poor bioavailability (PAV). The addition of SJW increased the ACE, α-amylase, and LOX inhibitory effect, but reduced the inhibition of pancreatic lipase. The highest antioxidant activity was noted for 1.0 SJW. The results showed that only 0.5 SJW and 1.0 SJW had slight antimicrobial activity against E. coli ATCC 25922 and B. cereus ATCC 14579 with MIC = 12.5 mg mL−1. Fractions with molecular mass <3.0 kDa were characterized with the highest p-coumaric acid content. The results show that SJW cookies had a higher content of bioactive compounds and more potent anti-metabolic syndrome effects.

Production of adventitious roots and secondary metabolites by Hypericum perforatum L. in a bioreactor

2010 ◽  
Vol 101 (12) ◽  
pp. 4708-4716 ◽  
Author(s):  
Xi-Hua Cui ◽  
Debasis Chakrabarty ◽  
Eun-Jung Lee ◽  
Kee-Yoeup Paek
Keyword(s):  
Secondary Metabolites ◽  
Adventitious Roots ◽  
Hypericum Perforatum ◽  
Hypericum Perforatum L

Variation in concentrations of major bioactive compounds in Hypericum perforatum L. from Lithuania

2012 ◽  
Vol 35 (1) ◽  
pp. 302-308 ◽  
Author(s):  
Edita Bagdonaitė ◽  
Pavol Mártonfi ◽  
Miroslav Repčák ◽  
Juozas Labokas
Keyword(s):  
Bioactive Compounds ◽  
Hypericum Perforatum ◽  
Hypericum Perforatum L

Quantitation of oligomeric procyanidin clusters with defined degree of polymerisation from Hypericum perforatum L.

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
N Hellenbrand ◽  
F Petereit ◽  
M Lechtenberg ◽  
A Hensel
Keyword(s):  
Hypericum Perforatum ◽  
Degree Of Polymerisation ◽  
Hypericum Perforatum L

Determination of Hypericin in St. John's Wort (Hypericum perforatum L.) extracts using HPLC-ED

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
E Sofic ◽  
A Copra Janicijevic ◽  
M Maksimovic ◽  
I Tahirovic ◽  
L Klepo ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L
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