Previous Trial Studies of Unexplained Recurrent Miscarriage

2018 ◽  
pp. 85-94 ◽  
Author(s):  
Keiji Kuroda
Keyword(s):  
Recurrent Miscarriage ◽  
Previous Trial ◽  
Unexplained Recurrent Miscarriage

scholarly journals Low molecular weight heparin use in unexplained recurrent miscarriage: safety and efficancy

1969 ◽  
Vol 30 (6) ◽  
Author(s):  
Semra Kayatas ◽  
Halide Yuksel ◽  
Aysen Boza ◽  
Murat Api ◽  
Aktug Ertekin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Recurrent Miscarriage ◽  
Low Molecular Weight ◽  
Unexplained Recurrent Miscarriage

Association of serum progesterone level and endometrial estradiol & progesterone receptors in women with unexplained recurrent miscarriage

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ihab Found Alam ◽  
Sherif Ahmed Ashoush ◽  
Ihab Adel Gomaa ◽  
Ahmed Sabry AbdEl-Hafeez
Keyword(s):  
Menstrual Cycle ◽  
Recurrent Miscarriage ◽  
Progesterone Receptors ◽  
First Trimester ◽  
Endometrial Biopsy ◽  
Serum Progesterone ◽  
Normal Endometrium ◽  
History Of ◽  
Unexplained Recurrent Miscarriage

Abstract This study investigated the endometrial tissue to study the fluctuation of estrogen receptors (ERs) and progesterone receptors (PRs) in women with recurrent miscarriage compared with normal endometrium of fertile women. Forty women were divided into two groups: 20 non-pregnant women with history of recurrent miscarriage (who had three or more first- trimester miscarriages) and 20 controls. Both groups had regular ovulatory menses and proven fertility. Endometrial biopsy was taken in the two groups during the luteal phase of the menstrual cycle, between the 8th and the 10th postovulatory days using an endometrial biopsy curette for determination of estrogen (E2) and progesterone (P4) hormones levels and their receptors. On the same day as the biopsy, a blood sample was taken for determination of estradiol (E2) and progesterone (P4) levels. The obtained results showed no significant differences between both groups regarding age, BMI, menarche, menstrual cycle & menstruation, significant decrease in E2 and P4 levels in the serum and endometrial biopsy of recurrent miscarriage women versus control. In control and recurrent miscarriage; ER levels in cytoplasm and salt extracted nucleus were higher than PR levels. ER and PR values were higher in the nuclear compartment than in the cytoplasmic compartment. The women with early recurrent miscarriage showed lower levels of both ER and PR significantly. All types of endometrial receptors (ER &PR) and hormones (E2 &P4) in serum and endometrium showed correlation relating to number of previous miscarriages.

Combined Thrombophilic Mutations in Women with Unexplained Recurrent Miscarriage

2007 ◽  
Vol 57 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Alexandros Sotiriadis ◽  
George Vartholomatos ◽  
Matthaios Pavlou ◽  
Nicolaos Kolaitis ◽  
Leucothea Dova ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Unexplained Recurrent Miscarriage ◽  
Thrombophilic Mutations

Chinese herbal medicines for unexplained recurrent miscarriage

2013 ◽  
Author(s):  
Lu Li ◽  
Lixia Dou ◽  
Ping Chung Leung ◽  
Tony Kwok Hung Chung ◽  
Chi Chiu Wang
Keyword(s):  
Recurrent Miscarriage ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Unexplained Recurrent Miscarriage

Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage

2005 ◽  
Vol 93 (05) ◽  
pp. 867-871 ◽  
Author(s):  
Manuela Krause ◽  
Barbara Sonntag ◽  
Robert Klamroth ◽  
Achim Heinecke ◽  
Carola Scholz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Recurrent Miscarriage ◽  
Univariate Analysis ◽  
Plasminogen Activator Inhibitor ◽  
Protein S ◽  
Factor V ◽  
Prothrombotic Risk Factors ◽  
Caucasian Women ◽  
Unexplained Recurrent Miscarriage

SummaryFrom 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677T, 4G/5G plasminogen activator inhibitor (PAI)-1, lipoprotein (Lp) (a), protein C (PC), protein S (PS), antithrombin (AT), antiphospholipid/anticardiolipin (APA/ACA) antibodies) as well as associated environmental conditions (smoking and obesity) were investigated. 70 (52.6%) of the patients had at least one prothrombotic risk factor compared with 26 control women (19.5%; p<0.0001). Body mass index (BMI; p=0.78) and smoking habits (p=0.44) did not differ significantly between the groups investigated. Upon univariate analysis the heterozygous FV mutation, Lp(a) > 30 mg/dL, increased APA/ACA and BMI > 25 kg/m2 in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate analysis, increased Lp(a) (odds ratio (OR): 4.7/95% confidence interval (CI): 2.0–10.7), the FV mutation (OR:3.8/CI:1.4–10.7), and increased APA/ACA (OR: 4.5/CI: 1.1–17.7) had independent associations with uRM.

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