Surgery and Operating Room for Restoring Organs: Organ Regeneration by Tissue Engineering in the Near Future

2020 ◽  
pp. 57-62
Author(s):  
Mitsuo Miyazawa ◽  
Masato Watanabe ◽  
Yoshihisa Naito ◽  
Yasumitsu Hirano ◽  
Keizo Taniguchi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Operating Room ◽  
Organ Regeneration ◽  
Near Future

scholarly journals Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Bossù ◽  
Andrea Pacifici ◽  
Daniele Carbone ◽  
Gianluca Tenore ◽  
Gaetano Ierardo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Current Knowledge ◽  
Dental Stem Cells ◽  
Therapeutic Tool ◽  
Exponential Increase ◽  
Major Interest ◽  
Adult Mesenchymal Stem Cells ◽  
Therapeutic Protocols ◽  
Near Future

In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

scholarly journals Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration

2021 ◽  
Vol 10 ◽  
pp. 100107
Author(s):  
N. Contessi Negrini ◽  
A. Angelova Volponi ◽  
C.A. Higgins ◽  
P.T. Sharpe ◽  
A.D. Celiz
Keyword(s):  
Tissue Engineering ◽  
Organ Regeneration

Textile Scaffolds for Tissue Engineering – Near Future or Just Vision?

2010 ◽  
pp. 353-356
Author(s):  
D. Aibibu ◽  
S. Houis ◽  
M. Sri Harwoko ◽  
Th. Gries
Keyword(s):  
Tissue Engineering ◽  
Near Future

scholarly journals Biodegradable Microfluidic Scaffolds for Vascular Tissue Engineering

2004 ◽  
Vol 845 ◽  
Author(s):  
C. J. Bettinger ◽  
J. T. Borenstein ◽  
R. S. Langer
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Time Lag ◽  
Three Dimensional ◽  
Single Layer ◽  
Vascular Tissue Engineering ◽  
Engineering Applications ◽  
Organ Regeneration ◽  
Superior Mechanical Properties ◽  
Microfabrication Techniques

ABSTRACTThis work describes the integration of novel microfabrication techniques for vascular tissue engineering applications in the context of a novel biodegradable elastomer. The field of tissue engineering and organ regeneration has been borne out of the high demand for organ transplants. However, one of the critical limitations in regeneration of vital organs is the lack of an intrinsic blood supply. This work expands on the development of scaffolds for vascular tissue engineering applications by employing microfabrication techniques. Unlike previous efforts, this work focuses on fabricating single layer and three-dimensional scaffolds from poly(glycerol-sebacate) (PGS), a novel biodegradable elastomer with superior mechanical properties. The transport properties of oxygen and carbon dioxide in PGS were measured through a series of time-lag diffusion experiments. The results of these measurements were used to calculate a characteristic length scale for oxygen diffusion limits in solid PGS scaffolds. Single layer and three-dimensional microfluidic scaffolds were then produced using fabrication techniques specific for PGS. This work has resulted in the fabrication of solid PGS-based scaffolds with biomimetic fluid flow and capillary channels on the order of 10 microns in width. Fabrication of complex, three-dimensional microfluidic PGS scaffolds was also demonstrated by stacking and bonding multiple microfluidic layers.

Inventory Cost Reduction in the Perioperative Setting

2001 ◽  
Vol 36 (5) ◽  
pp. 514-517
Author(s):  
Toni Elkach
Keyword(s):  
Operating Room ◽  
Inventory Control ◽  
Cost Reduction ◽  
Postanesthesia Care Unit ◽  
Intravenous Fluids ◽  
Inventory Cost ◽  
Anesthesia Department ◽  
Neuromuscular Blockers ◽  
Inventory Turnover ◽  
Near Future

An inventory cost-reduction project for our operating room was undertaken to reduce excess inventory, increase inventory turnover, and eliminate unusable items. The operating area consisted of three departments with different inventory control potentials. In the anesthesia department, the targeted areas with corresponding results in inventory savings were: anesthesiologists' trays stock, $2344; refrigerated neuromuscular blockers, $2025; intravenous fluids and miscellaneous items, $2817; reduction of midazolam waste, $5907. Inventory reductions in the postanesthesia care unit and the operating room (the second and third departments) totaled $565 and $496, respectively. In addition, a yearly report run by the pharmacy and its purposes were discussed. These simple interventions led to inventory savings of $14,154. Projects now underway should lead to more impressive results in the near future.

scholarly journals Multinozzle Multichannel Temperature Deposition System for Construction of a Blood Vessel

2017 ◽  
Vol 23 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Huanbao Liu ◽  
Huixing Zhou ◽  
Haiming Lan ◽  
Fu Liu ◽  
Xuhan Wang
Keyword(s):  
Tissue Engineering ◽  
Blood Vessel ◽  
3D Model ◽  
Model Structure ◽  
3D Bioprinting ◽  
Porous Structures ◽  
Bioactive Materials ◽  
Organ Regeneration ◽  
Hierarchical Porous ◽  
Temperature Deposition

3D bioprinting is an emerging technology that drives us to construct the complicated tissues and organs consisting of various materials and cells, which has been in widespread use in tissue engineering and organ regeneration. However, the protection and accurate distribution of cells are the most urgent problems to achieve tissue and organ reconstruction. In this article, a multinozzle multichannel temperature deposition and manufacturing (MTDM) system is proposed to fabricate a blood vessel with heterogeneous materials and gradient hierarchical porous structures, which enables not only the reconstruction of a blood vessel with an accurate 3D model structure but also the capacity to distribute bioactive materials such as growth factors, nutrient substance, and so on. In addition, a coaxial focusing nozzle is proposed and designed to extrude the biomaterial and encapsulation material, which can protect the cell from damage. In the MTDM system, the tubular structure of a blood vessel was successfully fabricated with the different biomaterials, which proved that the MTDM system has a potential application prospect in tissue engineering and organ regeneration.

scholarly journals Tissue Engineering in Musculoskeletal Tissue: A Review of the Literature

Surgeries ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 58-82
Author(s):  
Mary Bove ◽  
Annalisa Carlucci ◽  
Giovanni Natale ◽  
Chiara Freda ◽  
Antonio Noro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Living Cells ◽  
Physical Factors ◽  
Clinical Use ◽  
Muscle Loss ◽  
Review Of The Literature ◽  
Musculoskeletal Tissue ◽  
Volumetric Muscle Loss ◽  
Structural And Functional Properties ◽  
Near Future

Tissue engineering refers to the attempt to create functional human tissue from cells in a laboratory. This is a field that uses living cells, biocompatible materials, suitable biochemical and physical factors, and their combinations to create tissue-like structures. To date, no tissue engineered skeletal muscle implants have been developed for clinical use, but they may represent a valid alternative for the treatment of volumetric muscle loss in the near future. Herein, we reviewed the literature and showed different techniques to produce synthetic tissues with the same architectural, structural and functional properties as native tissues.

Functional Tissue Engineering Through Biofunctional Macromolecules and Surface Design

MRS Bulletin ◽  
2010 ◽  
Vol 35 (8) ◽  
pp. 584-590 ◽  
Author(s):  
Lorenzo Moroni ◽  
Pamela Habibovic ◽  
David J. Mooney ◽  
Clemens A. van Blitterswijk
Keyword(s):  
Tissue Engineering ◽  
Tissue Formation ◽  
Cellular Phenotype ◽  
3D Scaffolds ◽  
Surface Design ◽  
Engineered Tissue ◽  
Porous Biomaterials ◽  
Near Future

AbstractTissue engineering is a rapidly developing discipline that has already entered the clinics and will tremendously change patient management in the near future. The aim of classical tissue engineering is to heal damaged or diseased tissues and organs through the combination of cells, biological factors, and porous biomaterials. The resulting, engineered tissue must possess appropriate functional properties to replace or supplement the targeted tissue. This is still a challenge to overcome before tissue-engineered products can be considered a complete success. Classical tissue engineering approaches rely on the use of mature cells expanded in vitro and transplanted alone or seeded in passive 3D scaffolds, which can lead to the loss of cellular phenotype and production of nonfunctional extracellular matrix. An emerging strategy involves the design of bioactive 3D scaffolds with instructive properties able to recruit cells in situ and direct tissue formation. Here, we present and discuss recent efforts to achieve smart scaffolds encompassing macromolecular biofunctionalization and surface design.

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