Regenerative Medicine in the Operating Room at Present and in the Near Future

2020 ◽  
pp. 47-55
Author(s):  
Kengo Kanetaka ◽  
Susumu Eguchi
Keyword(s):  
Regenerative Medicine ◽  
Operating Room ◽  
Near Future

Inventory Cost Reduction in the Perioperative Setting

2001 ◽  
Vol 36 (5) ◽  
pp. 514-517
Author(s):  
Toni Elkach
Keyword(s):  
Operating Room ◽  
Inventory Control ◽  
Cost Reduction ◽  
Postanesthesia Care Unit ◽  
Intravenous Fluids ◽  
Inventory Cost ◽  
Anesthesia Department ◽  
Neuromuscular Blockers ◽  
Inventory Turnover ◽  
Near Future

An inventory cost-reduction project for our operating room was undertaken to reduce excess inventory, increase inventory turnover, and eliminate unusable items. The operating area consisted of three departments with different inventory control potentials. In the anesthesia department, the targeted areas with corresponding results in inventory savings were: anesthesiologists' trays stock, $2344; refrigerated neuromuscular blockers, $2025; intravenous fluids and miscellaneous items, $2817; reduction of midazolam waste, $5907. Inventory reductions in the postanesthesia care unit and the operating room (the second and third departments) totaled $565 and $496, respectively. In addition, a yearly report run by the pharmacy and its purposes were discussed. These simple interventions led to inventory savings of $14,154. Projects now underway should lead to more impressive results in the near future.

scholarly journals Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

2021 ◽  
Author(s):  
Rui D. Alvites ◽  
Mariana Vieira Branquinho ◽  
Ana Catarina Sousa ◽  
Bruna Lopes ◽  
Patrícia Sousa ◽  
...  
Keyword(s):  
Animal Models ◽  
Regenerative Medicine ◽  
Medical Research ◽  
Small Ruminants ◽  
Future Perspectives ◽  
Feeding Costs ◽  
Classical Models ◽  
Long Life ◽  
Near Future ◽  
Physiological Systems

Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

scholarly journals FOUR-DIMENSIONAL BIOPRINTING FOR REGENERATIVE MEDICINE: MECHANISMS TO INDUCE SHAPE VARIATION AND POTENTIAL APPLICATIONS

2019 ◽  
pp. 36-43 ◽  
Author(s):  
Pedro Morouço
Keyword(s):  
Regenerative Medicine ◽  
Creative Thinking ◽  
Main Idea ◽  
Layer By Layer ◽  
Shape Variation ◽  
Exciting Field ◽  
Testing Procedures ◽  
Different Types ◽  
Near Future

Regenerative medicine is an exciting field of research, in which significant steps are being taken that are leading to the translation of the technique into clinical practice. In the near future, it is expected that clinicians will have the opportunity to bioprint tissues and organs that closely mimic native human tissues. To do so, imaging of patients must be translated to digital models and then fabricated in a layer-by-layer fashion. The main aim of this review is to elaborate on the possible mechanisms that support four-dimensional bioprinting, as well as provide examples of current and future applications of the technology. This technology, considering time as the fourth dimension, emerged with the aim to develop bioactive functional constructs with programmed stimuli responses. The main idea is to have three-dimensional-printed constructs that are responsive to preplanned stimuli. With this review, the authors aim to provoke creative thinking, highlighting several issues that need to be addressed when reproducing such a complex network as the human body. The authors envision that there are some key features that need to be studied in the near future: printed constructs should be able to respond to different types of stimuli in a timely manner, bioreactors must be developed combining different types of automated stimuli and aiming to replicate the in vivo ecology, and adequate testing procedures must be developed to obtain a proper assessment of the constructs. The effective development of a printed construct that supports tissue maturation according to the anticipated stimuli will significantly advance this promising approach to regenerative medicine.

scholarly journals Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 249
Author(s):  
Rui Damásio Alvites ◽  
Mariana Vieira Branquinho ◽  
Ana Catarina Sousa ◽  
Bruna Lopes ◽  
Patrícia Sousa ◽  
...  
Keyword(s):  
Animal Models ◽  
Regenerative Medicine ◽  
Small Ruminants ◽  
Laboratory Animals ◽  
Future Perspectives ◽  
Feeding Costs ◽  
Classical Models ◽  
Long Life ◽  
Near Future ◽  
Physiological Systems

Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions, larger than conventional laboratory animals, but very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with a focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

scholarly journals Stem cells in the amniotic fluid: the new chance of regenerative medicine

2011 ◽  
Vol 152 (15) ◽  
pp. 581-587 ◽  
Author(s):  
József Gábor Joó
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
Diagnostic Tool ◽  
Congenital Malformations ◽  
Genetic Diseases ◽  
Storage Diseases ◽  
Amniotic Fluid Stem Cells ◽  
Amniotic Fluid Stem Cell ◽  
Near Future

Amniotic fluid has been used in prenatal diagnosis for more than decades. It yields a simple and reliable screening and diagnostic tool for a variety of congenital malformations and genetic diseases such as chromosomal aberrations, neural tube defects or storage diseases. Nowadays the widening knowledge provides evidence that amniotic fluid is not only a screening and diagnostic tool, but it may be also the source of the effective therapy of several congenital and adult disorders. A subset of cells, the so-called stem cells were found in the amniotic fluid as well as the placenta, and they proved to be capable of maintaining prolonged undifferentiated proliferation. Stem cells are able to differentiate into multiple tissue types, originating from the three germ layers. In the near future stem cells isolated from amniotic fluid or placenta and stored by cryopreservation may play a significant role in regenerative medicine. Congenital malformations as well as certain diseases in adults might be treated by tissues coming from progenitor cells of amniotic fluid stem cell origin. This study gives a summary of the main characteristics of amniotic fluid stem cells and it also presents important examples of their possible clinical application. Orv. Hetil., 2011, 152, 581–587.

scholarly journals Induced pluripotent stem cells reprogramming: Epigenetics and applications in the regenerative medicine

2017 ◽  
Vol 63 (2) ◽  
pp. 180-189 ◽  
Author(s):  
Kátia Maria Sampaio Gomes ◽  
Ismael Cabral Costa ◽  
Jeniffer Farias dos Santos ◽  
Paulo Magno Martins Dourado ◽  
Maria Fernanda Forni ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Limiting Factor ◽  
New Strategy ◽  
New Type ◽  
Low Efficiency ◽  
Induced Pluripotent ◽  
Near Future

Summary Induced pluripotent stem cells (iPSCs) are somatic cells reprogrammed into an embryonic-like pluripotent state by the expression of specific transcription factors. iPSC technology is expected to revolutionize regenerative medicine in the near future. Despite the fact that these cells have the capacity to self-renew, they present low efficiency of reprogramming. Recent studies have demonstrated that the previous somatic epigenetic signature is a limiting factor in iPSC performance. Indeed, the process of effective reprogramming involves a complete remodeling of the existing somatic epigenetic memory, followed by the establishment of a "new epigenetic signature" that complies with the new type of cell to be differentiated. Therefore, further investigations of epigenetic modifications associated with iPSC reprogramming are required in an attempt to improve their self-renew capacity and potency, as well as their application in regenerative medicine, with a new strategy to reduce the damage in degenerative diseases. Our review aimed to summarize the most recent findings on epigenetics and iPSC, focusing on DNA methylation, histone modifications and microRNAs, highlighting their potential in translating cell therapy into clinics.

Surgery and Operating Room for Restoring Organs: Organ Regeneration by Tissue Engineering in the Near Future

2020 ◽  
pp. 57-62
Author(s):  
Mitsuo Miyazawa ◽  
Masato Watanabe ◽  
Yoshihisa Naito ◽  
Yasumitsu Hirano ◽  
Keizo Taniguchi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Operating Room ◽  
Organ Regeneration ◽  
Near Future

scholarly journals Recombinant Proteins-Based Strategies in Bone Tissue Engineering

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 3
Author(s):  
Marina Paulini ◽  
Iván Nadir Camal Ruggieri ◽  
Melina Ramallo ◽  
Matilde Alonso ◽  
José Carlos Rodriguez-Cabello ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Recombinant Proteins ◽  
Complex Structure ◽  
High Impact ◽  
Special Importance ◽  
Near Future ◽  
Very High

The increase in fracture rates and/or problems associated with missing bones due to accidents or various pathologies generates socio-health problems with a very high impact. Tissue engineering aims to offer some kind of strategy to promote the repair of damaged tissue or its restoration as close as possible to the original tissue. Among the alternatives proposed by this specialty, the development of scaffolds obtained from recombinant proteins is of special importance. Furthermore, science and technology have advanced to obtain recombinant chimera’s proteins. This review aims to offer a synthetic description of the latest and most outstanding advances made with these types of scaffolds, particularly emphasizing the main recombinant proteins that can be used to construct scaffolds in their own right, i.e., not only to impregnate them, but also to make scaffolds from their complex structure, with the purpose of being considered in bone regenerative medicine in the near future.

scholarly journals History and Physiology of Plasmatic Growth Factors in Regenerative Medicine

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Growth Factors ◽  
Regenerative Medicine ◽  
Sports Medicine ◽  
Production Capacity ◽  
Biological Cycle ◽  
Medical Discipline ◽  
Medical Indications ◽  
Biochemical Signals ◽  
Near Future

There is no doubt that the use of plasma growth factors, within what is known as regenerative medicine, is emerging as a new medical discipline with a lot of clinical applications. Since its inception in use in sports medicine and dental implants in the mid-80s, gradually it has expanded its field of use in clinical specialties. More and more data on the physiology of angiotrope, immunomodulatory and cellular trophic power are known every day. Both the growth factors present in platelets and leukocytes produce on the cellular biological cycle, intervening in the processes of duplication, differentiation and apoptosis such as biochemical signals in the form of cytokine or chemokine cascades that intervene in the activation of these phenomena, through inflammation or ischemia, as well as the interrelationship between themNotwithstanding the great offer of existing indications and duplication of procedures for obtaining, which surpasses the scientific production capacity on this subject, that is questioning a biotechnology that well used in the near future will help improve the quality of life of the patients , optimizing those medical indications where it really is useful.

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