Trends in Functional Biomaterials in Tissue Engineering and Regenerative Medicine

The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that mimic the in vivo microenvironment. Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions, ranging from the extracellular matrix (ECM) for structural and biochemical support of cells to the holy lotus with special wettability for self-cleaning effects. Many of these systems found in biology possess unique surface properties recognised to regulate cell behaviour. Integration of such natural surface properties in biomaterials can bring about novel cell responses in vitro and provide greater insights into the processes occurring at the cell-biomaterial interface. Using natural surfaces as templates for bioinspired design can stimulate progress in the field of regenerative medicine, tissue engineering and biomaterials science. This literature review aims to combine the state-of-the-art knowledge in natural and nature-inspired surfaces, with an emphasis on material properties known to affect cell behaviour.

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Recent developments in mussel-inspired materials for biomedical applications

Biomaterials Science ◽

10.1039/d1bm01126j ◽

2021 ◽

Author(s):

Natan Roberto Barros ◽

Yi Chen ◽

Vahid Hosseini ◽

Weiyue Wang ◽

Rohollah Nasiri ◽

...

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine ◽

Biomedical Applications ◽

Recent Developments ◽

Functional Biomaterials

Over the decades, researchers have strived to synthesize and modify nature-inspired biomaterials, with the primary aim to address the challenges of designing functional biomaterials for regenerative medicine and tissue engineering....

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Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine

BioMed Research International ◽

10.1155/2015/821279 ◽

2015 ◽

Vol 2015 ◽

pp. 1-15 ◽

Cited By ~ 203

Author(s):

Martin Rodríguez-Vázquez ◽

Brenda Vega-Ruiz ◽

Rodrigo Ramos-Zúñiga ◽

Daniel Alexander Saldaña-Koppel ◽

Luis Fernando Quiñones-Olvera

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine ◽

Biomedical Applications ◽

Therapeutic Strategy ◽

Biological Properties ◽

Natural Polymers ◽

Tissue Engineering Scaffolds ◽

Promising Alternative ◽

Functional Biomaterials ◽

Potential Use

Tissue engineering is an important therapeutic strategy to be used in regenerative medicine in the present and in the future. Functional biomaterials research is focused on the development and improvement of scaffolding, which can be used to repair or regenerate an organ or tissue. Scaffolds are one of the crucial factors for tissue engineering. Scaffolds consisting of natural polymers have recently been developed more quickly and have gained more popularity. These include chitosan, a copolymer derived from the alkaline deacetylation of chitin. Expectations for use of these scaffolds are increasing as the knowledge regarding their chemical and biological properties expands, and new biomedical applications are investigated. Due to their different biological properties such as being biocompatible, biodegradable, and bioactive, they have given the pattern for use in tissue engineering for repair and/or regeneration of different tissues including skin, bone, cartilage, nerves, liver, and muscle. In this review, we focus on the intrinsic properties offered by chitosan and its use in tissue engineering, considering it as a promising alternative for regenerative medicine as a bioactive polymer.

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Tissue engineering in regenerative medicine

Forum Zakażeń ◽

10.15374/fz2015052 ◽

2015 ◽

Vol 6 (5) ◽

pp. 291-298

Author(s):

Barbara Różalska ◽

Bartłomiej Micota ◽

Małgorzata Paszkiewicz ◽

Beata Sadowska

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine

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Graphene and Graphene-Based Materials in Biomedical Applications

Current Medicinal Chemistry ◽

10.2174/0929867326666190705155854 ◽

2019 ◽

Vol 26 (38) ◽

pp. 6834-6850 ◽

Cited By ~ 5

Author(s):

Mohammad Omaish Ansari ◽

Kalamegam Gauthaman ◽

Abdurahman Essa ◽

Sidi A. Bencherif ◽

Adnan Memic

Keyword(s):

Tissue Engineering ◽

Thermal Properties ◽

Gene Delivery ◽

Regenerative Medicine ◽

Biomedical Research ◽

Biomedical Applications ◽

Biomedical Application ◽

Two Dimensional ◽

Drug And Gene Delivery ◽

Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

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